pT1 亚分类预测膀胱肿瘤标本整体切除术的无进展生存期

IF 3.7 3区 医学 Q2 MEDICAL LABORATORY TECHNOLOGY
Shun Sato, Takafumi Yanagisawa, Jun Miki, Yasushi Hayashida, Yohei Okada, Kosuke Iwatani, Akihiro Matsukawa, Takahiro Kimura, Shin Egawa, Masayuki Shimoda, Hiroyuki Takahashi
{"title":"pT1 亚分类预测膀胱肿瘤标本整体切除术的无进展生存期","authors":"Shun Sato, Takafumi Yanagisawa, Jun Miki, Yasushi Hayashida, Yohei Okada, Kosuke Iwatani, Akihiro Matsukawa, Takahiro Kimura, Shin Egawa, Masayuki Shimoda, Hiroyuki Takahashi","doi":"10.5858/arpa.2023-0044-OA","DOIUrl":null,"url":null,"abstract":"<p><strong>Context: </strong>The pathologic diagnosis of pT1 substage in conventional transurethral resection of bladder tumor specimens is inaccurate and has low interobserver reproducibility owing to fragmentation and cauterization of the specimens. En bloc resection of bladder tumor is a novel surgical procedure that improves diagnostic feasibility and accuracy in the pathologic diagnosis of bladder cancer, including depth and extent of invasion.</p><p><strong>Objective: </strong>To examine the prognostic value of multiple pT1 subclassification methods, using only en bloc resection specimens.</p><p><strong>Design: </strong>We examined 106 patients with T1 bladder cancer who underwent en bloc resection. The pT1 substages were assigned by 3 different subclassification methods by using the muscularis mucosae or stalk of the papillary lesion as diagnostic landmarks or millimetric depth of invasion. Intergroup differences in progression-free survival and recurrence-free survival rates were analyzed. The prognostic values of clinicopathologic factors for progression/recurrence were analyzed by using multivariate analysis.</p><p><strong>Results: </strong>The pT1 substage was evaluable in all cases. Tumors with invasion into/beyond the muscularis mucosae and those beyond the stalk of the papillary lesion were associated with worse progression-free survival (P = .002 and P = .01, respectively). Notably, no patient with invasion confined to the stalk had disease progression during the 23-month median follow-up period. Only the pT1 subclassification method using the muscularis mucosae was an independent prognosticator of progression in multivariate analysis (P = .03).</p><p><strong>Conclusions: </strong>Precise pathologic subclassification of invasion using en bloc resection specimens may enable accurate prognosis and assessment in patients with bladder cancer with suspicious shallow invasion.</p>","PeriodicalId":8305,"journal":{"name":"Archives of pathology & laboratory medicine","volume":" ","pages":"573-580"},"PeriodicalIF":3.7000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"pT1 Subclassification Predicts Progression-Free Survival in En Bloc Resection of Bladder Tumor Specimens.\",\"authors\":\"Shun Sato, Takafumi Yanagisawa, Jun Miki, Yasushi Hayashida, Yohei Okada, Kosuke Iwatani, Akihiro Matsukawa, Takahiro Kimura, Shin Egawa, Masayuki Shimoda, Hiroyuki Takahashi\",\"doi\":\"10.5858/arpa.2023-0044-OA\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Context: </strong>The pathologic diagnosis of pT1 substage in conventional transurethral resection of bladder tumor specimens is inaccurate and has low interobserver reproducibility owing to fragmentation and cauterization of the specimens. En bloc resection of bladder tumor is a novel surgical procedure that improves diagnostic feasibility and accuracy in the pathologic diagnosis of bladder cancer, including depth and extent of invasion.</p><p><strong>Objective: </strong>To examine the prognostic value of multiple pT1 subclassification methods, using only en bloc resection specimens.</p><p><strong>Design: </strong>We examined 106 patients with T1 bladder cancer who underwent en bloc resection. The pT1 substages were assigned by 3 different subclassification methods by using the muscularis mucosae or stalk of the papillary lesion as diagnostic landmarks or millimetric depth of invasion. Intergroup differences in progression-free survival and recurrence-free survival rates were analyzed. The prognostic values of clinicopathologic factors for progression/recurrence were analyzed by using multivariate analysis.</p><p><strong>Results: </strong>The pT1 substage was evaluable in all cases. Tumors with invasion into/beyond the muscularis mucosae and those beyond the stalk of the papillary lesion were associated with worse progression-free survival (P = .002 and P = .01, respectively). Notably, no patient with invasion confined to the stalk had disease progression during the 23-month median follow-up period. Only the pT1 subclassification method using the muscularis mucosae was an independent prognosticator of progression in multivariate analysis (P = .03).</p><p><strong>Conclusions: </strong>Precise pathologic subclassification of invasion using en bloc resection specimens may enable accurate prognosis and assessment in patients with bladder cancer with suspicious shallow invasion.</p>\",\"PeriodicalId\":8305,\"journal\":{\"name\":\"Archives of pathology & laboratory medicine\",\"volume\":\" \",\"pages\":\"573-580\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of pathology & laboratory medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5858/arpa.2023-0044-OA\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICAL LABORATORY TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of pathology & laboratory medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5858/arpa.2023-0044-OA","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

背景:传统经尿道膀胱肿瘤切除术标本的病理诊断 pT1 亚分期不准确,而且由于标本破碎和烧灼,观察者之间的可重复性很低。膀胱肿瘤整体切除术是一种新型手术方法,可提高膀胱癌病理诊断的可行性和准确性,包括侵犯深度和范围:仅使用全切标本研究多种 pT1 亚分类方法的预后价值:我们对 106 名接受全切的 T1 膀胱癌患者进行了研究。采用3种不同的亚分类方法,以粘膜肌肉或乳头状病变的柄部作为诊断标志或以毫米为单位的浸润深度来划分pT1亚型。分析了无进展生存率和无复发生存率的组间差异。采用多变量分析法对临床病理因素对进展/复发的预后价值进行了分析:结果:所有病例的 pT1 亚分期均可评估。肿瘤侵犯粘膜肌层或超出粘膜肌层以及超出乳头状病变柄的肿瘤与较差的无进展生存期相关(分别为 P = .002 和 P = .01)。值得注意的是,在23个月的中位随访期间,没有一名侵犯范围局限于柄部的患者出现疾病进展。在多变量分析中,只有使用粘膜肌的pT1亚分类方法是疾病进展的独立预后指标(P = .03):结论:使用整体切除标本对侵犯进行精确的病理亚分类,可对可疑浅表侵犯的膀胱癌患者进行准确的预后和评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
pT1 Subclassification Predicts Progression-Free Survival in En Bloc Resection of Bladder Tumor Specimens.

Context: The pathologic diagnosis of pT1 substage in conventional transurethral resection of bladder tumor specimens is inaccurate and has low interobserver reproducibility owing to fragmentation and cauterization of the specimens. En bloc resection of bladder tumor is a novel surgical procedure that improves diagnostic feasibility and accuracy in the pathologic diagnosis of bladder cancer, including depth and extent of invasion.

Objective: To examine the prognostic value of multiple pT1 subclassification methods, using only en bloc resection specimens.

Design: We examined 106 patients with T1 bladder cancer who underwent en bloc resection. The pT1 substages were assigned by 3 different subclassification methods by using the muscularis mucosae or stalk of the papillary lesion as diagnostic landmarks or millimetric depth of invasion. Intergroup differences in progression-free survival and recurrence-free survival rates were analyzed. The prognostic values of clinicopathologic factors for progression/recurrence were analyzed by using multivariate analysis.

Results: The pT1 substage was evaluable in all cases. Tumors with invasion into/beyond the muscularis mucosae and those beyond the stalk of the papillary lesion were associated with worse progression-free survival (P = .002 and P = .01, respectively). Notably, no patient with invasion confined to the stalk had disease progression during the 23-month median follow-up period. Only the pT1 subclassification method using the muscularis mucosae was an independent prognosticator of progression in multivariate analysis (P = .03).

Conclusions: Precise pathologic subclassification of invasion using en bloc resection specimens may enable accurate prognosis and assessment in patients with bladder cancer with suspicious shallow invasion.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
9.20
自引率
2.20%
发文量
369
审稿时长
3-8 weeks
期刊介绍: Welcome to the website of the Archives of Pathology & Laboratory Medicine (APLM). This monthly, peer-reviewed journal of the College of American Pathologists offers global reach and highest measured readership among pathology journals. Published since 1926, ARCHIVES was voted in 2009 the only pathology journal among the top 100 most influential journals of the past 100 years by the BioMedical and Life Sciences Division of the Special Libraries Association. Online access to the full-text and PDF files of APLM articles is free.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信