白介素-18和白介素-17a和转化生长因子β标志物在糖尿病肾病发病机制中的作用。

IF 1.4 Q3 Pharmacology, Toxicology and Pharmaceutics
Maysam Adnan Mezher, Mohanad Yasir Al-Radeef, Khalid Saud Salih
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引用次数: 0

摘要

在糖尿病中,微血管损伤通常针对肾脏,使其成为受影响最重要的器官。由于疾病本身或其他伴随的健康问题,如高血压和衰老导致的肾单位损失,相当多的患者最终会患上肾病。本研究旨在分析伊拉克成年糖尿病肾病(DKD)患者血清中细胞因子(白细胞介素[IL]-18、IL-17a和转化生长因子β)的浓度。目前的调查于2022年10月至2023年1月在提克里特教学医院/萨拉哈丁省进行。从DKD患者身上采集了60份血样。通过酶联免疫吸附测定测定样品中IL-18、IL-17a和TGF-β标志物的血清水平。本研究结果显示,不同年龄组临床人群之间存在显著差异(P<0.05),51-60岁和>60岁的患者得分最高(28%和33%),21-30岁和31-40岁的患者评分最高(8.3%和13.3%),患者的TGF-β标记物(200.30±59.50、102.13±50.82和57.15±18.90)高于健康人(104.50±31.01、42.90±10.55和31.90±8.83)。根据Pearson相关结果,IL-17a与TGF-β呈显著负相关(r=-0.270*Sig.=0.037),TGF-β标记物在DKD患者筛查中的敏感性最高(98%、96%和87%),特异性最高(94%、97%和80%)。根据分析,可以推断疾病强度通常会随着年龄的增长而恶化。IL-18、IL-17a和TGF-β是筛查DKD患者的良好预后标志物。这些细胞因子为DKD治疗提供了一个有前景的治疗干预靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Roles of interleukins (interleukin-18 and interleukin-17a) and transforming growth factor-beta markers in the pathogenesis of diabetic kidney diseases.

Roles of interleukins (interleukin-18 and interleukin-17a) and transforming growth factor-beta markers in the pathogenesis of diabetic kidney diseases.

Roles of interleukins (interleukin-18 and interleukin-17a) and transforming growth factor-beta markers in the pathogenesis of diabetic kidney diseases.

Roles of interleukins (interleukin-18 and interleukin-17a) and transforming growth factor-beta markers in the pathogenesis of diabetic kidney diseases.

In diabetes, microvascular damage often targets the kidney, making them the most crucial organ affected. Due to the disease itself or other accompanying health issues such as hypertension and nephron loss due to aging, a significant number of patients end up with kidney disease. The current research aimed to analyze the concentration of cytokines in the serum (Interleukin [IL]-18, IL-17a and transforming growth factor-beta (TGF-β) in Iraqi adult patients with diabetic kidney disease (DKD). The current investigation was carried out in Tikrit Teaching Hospital/Salahaddin governorate for the time from October 2022 to January 2023. Sixty blood specimens were obtained from patients with DKD. Serum levels of IL-18, IL-17a, and TGF-β markers in the samples were subjected to measurement by enzyme-linked immunosorbent assay. Results of the present study showed significant differences (P < 0.05) among different age categories of clinical populations with 51-60 and >60 years scoring highest (28% and 33%), whereas 21-30 and 31-40 years scored (8.3% and 13.3%). The concentration of IL-18, IL-17a, and TGF-β markers was high in patients (200.30 ± 59.50, 102.13 ± 50.82, and 57.15 ± 18.90) than in healthy individuals (104.50 ± 31.01, 42.90 ± 10.55, and 31.90 ± 8.83). Based on the Pearson's correlation results, IL-17a had a significant negative correlation with TGF-β (r = -0.270* Sig. =0.037). Moreover, the receiver operating characteristic curve showed the IL-18, IL-17a, and TGF-β markers scored the highest sensitivity (98%, 96%, and 87%) and specificity (94%, 97%, and 80%), respectively, in screening patients with DKD. Based on the analysis, it could be inferred that disease intensity generally tends to worsen with an increase in age. IL-18, IL-17a, and TGF-β are good prognostic markers in screening patients with DKD. These cytokines present a promising target for therapeutic interventions in DKD therapy.

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来源期刊
CiteScore
2.00
自引率
7.10%
发文量
44
审稿时长
20 weeks
期刊介绍: Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is an Official Publication of Society of Pharmaceutical Education & Research™. It is an international journal published Quarterly. Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is available in online and print version. It is a peer reviewed journal aiming to communicate high quality original research work, reviews, short communications, case report, Ethics Forum, Education Forum and Letter to editor that contribute significantly to further the scientific knowledge related to the field of Pharmacy i.e. Pharmaceutics, Pharmacology, Pharmacognosy, Pharmaceutical Chemistry. Articles with timely interest and newer research concepts will be given more preference.
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