芳香氨基酸及其与肠道微生物群相关代谢产物的相互作用对妊娠期糖尿病风险的影响:一项中国队列的前瞻性嵌套病例对照研究。

IF 3.2 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Annals of Nutrition and Metabolism Pub Date : 2023-01-01 Epub Date: 2023-06-20 DOI:10.1159/000531481
Ninghua Li, Jing Li, Hui Wang, Jinnan Liu, Weiqin Li, Kai Yang, Xiaoxu Huo, Junhong Leng, Zhijie Yu, Gang Hu, Zhongze Fang, Xilin Yang
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引用次数: 0

摘要

引言:本研究的目的是探讨妊娠早期芳香族氨基酸(AAA)与妊娠期糖尿病(GDM)的关系,以及高AAA和肠道微生物群相关代谢产物是否对GDM风险有交互作用。方法:我们在2010年至2012年的孕妇前瞻性队列中进行了一项1:1的病例对照研究(n=486)。根据国际糖尿病与妊娠协会研究小组的标准,243名女性被诊断为GDM。采用二元条件logistic回归检验AAA与GDM风险的相关性。使用加性相互作用测量法检测了AAA和肠道微生物群相关代谢产物之间的相互作用。结果:高苯丙氨酸和色氨酸与GDM风险增加相关(OR:1.72,95%CI:1.07-27.78和1.66,1.02-2.71)。高三甲胺(TMA)的存在使单独高苯丙氨酸的OR显著增加至7.95(2.79-22.71),而低糖熊去氧胆酸(GUDCA)的存在使单独高色氨酸的OR显著提高至22.88(5.28-99.26),两者都具有显著的加性相互作用。此外,高溶血磷脂酰胆碱(LPC18:0)介导了这两种相互作用。结论:高苯丙氨酸与高TMA可能存在加性相互作用,而高色氨酸与低GUDCA可能存在增加GDM风险的加性交互作用,两者都是通过LPC18:0介导的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Aromatic Amino Acids and Their Interactions with Gut Microbiota-Related Metabolites for Risk of Gestational Diabetes: A Prospective Nested Case-Control Study in a Chinese Cohort.

Introduction: The aim of this study was to explore associations of aromatic amino acids (AAA) in early pregnancy with gestational diabetes mellitus (GDM), and whether high AAA and gut microbiota-related metabolites had interactive effects on GDM risk.

Methods: We conducted a 1:1 case-control study (n = 486) nested in a prospective cohort of pregnant women from 2010 to 2012. According to the International Association of Diabetes and Pregnancy Study Group's criteria, 243 women were diagnosed with GDM. Binary conditional logistic regression was performed to examine associations of AAA with GDM risk. Interactions between AAA and gut microbiota-related metabolites for GDM were examined using additive interaction measures.

Results: High phenylalanine and tryptophan were associated with increased GDM risk (OR: 1.72, 95% CI: 1.07-2.78 and 1.66, 1.02-2.71). The presence of high trimethylamine (TMA) markedly increased the OR of high phenylalanine alone up to 7.95 (2.79-22.71), while the presence of low glycoursodeoxycholic acid (GUDCA) markedly increased the OR of high tryptophan alone up to 22.88 (5.28-99.26), both with significant additive interactions. Furthermore, high lysophosphatidylcholines (LPC18:0) mediated both interactive effects.

Conclusions: High phenylalanine may have an additive interaction with high TMA, while high tryptophan may have an additive interaction with low GUDCA toward increased risk of GDM, both being mediated via LPC18:0.

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来源期刊
Annals of Nutrition and Metabolism
Annals of Nutrition and Metabolism 医学-内分泌学与代谢
CiteScore
6.50
自引率
0.00%
发文量
55
审稿时长
6-12 weeks
期刊介绍: ''Annals of Nutrition and Metabolism'' is a leading international peer-reviewed journal for sharing information on human nutrition, metabolism and related fields, covering the broad and multidisciplinary nature of science in nutrition and metabolism. As the official journal of both the International Union of Nutritional Sciences (IUNS) and the Federation of European Nutrition Societies (FENS), the journal has a high visibility among both researchers and users of research outputs, including policy makers, across Europe and around the world.
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