Emílio Itamar de Freitas Campos, Karina Braga Gomes, Daniel Dias Ribeiro, Marja Kaarina Puurunen, Aline de Oliveira Magalhães Mourão, Isadora Gonçalves Ferreira, Manoel Otávio da Costa Rocha, Renan Pedra de Souza, Maria Auxiliadora Parreiras Martins
{"title":"CYP2C9、VKORC1、MDR1和APOE基因多态性对巴西患者华法林维持剂量的影响。","authors":"Emílio Itamar de Freitas Campos, Karina Braga Gomes, Daniel Dias Ribeiro, Marja Kaarina Puurunen, Aline de Oliveira Magalhães Mourão, Isadora Gonçalves Ferreira, Manoel Otávio da Costa Rocha, Renan Pedra de Souza, Maria Auxiliadora Parreiras Martins","doi":"10.2217/pgs-2023-0099","DOIUrl":null,"url":null,"abstract":"<p><p><b>Background:</b> Polymorphisms in the <i>CYP2C9</i>, <i>VKORC1</i>, <i>MDR1</i> and <i>APOE</i> genes may impact warfarin dose. <b>Aim:</b> To investigate the influence of sociodemographic, clinical factors and polymorphisms <i>*1</i>, <i>*2</i> and <i>*3</i> for <i>CYP2C9</i>, -1639G>A for <i>VKORC1</i>, 3435C>T for <i>MDR1</i>, and ϵ2, ϵ3 and ϵ4 for <i>APOE</i> genes on the mean weekly warfarin maintenance dose in adults. <b>Methods:</b> This cross-sectional study recruited a calculated sample of 315 patients in three anticoagulation clinics in Brazil. A model containing the variables significantly associated with warfarin dose was estimated. <b>Results:</b> The mean age of patients was 64.1 ± 13.1 years, with 173 (54.9%) women. Age, use of amiodarone, genotype <i>VKORC1</i> GA, genotype <i>VKORC1</i> AA, genotypes <i>CYP2C9*1/*2</i> or <i>*1/*3</i> and genotypes <i>CYP2C9*2/*2</i> or <i>*2/*3</i> or <i>*3/*3</i> were associated with a reduced warfarin dose. <b>Conclusion:</b> This study pointed out factors that could impact the management of oral anticoagulation.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Influence of polymorphisms in <i>CYP2C9</i>, <i>VKORC1</i>, <i>MDR1</i> and <i>APOE</i> genes on the warfarin maintenance dose in Brazilian patients.\",\"authors\":\"Emílio Itamar de Freitas Campos, Karina Braga Gomes, Daniel Dias Ribeiro, Marja Kaarina Puurunen, Aline de Oliveira Magalhães Mourão, Isadora Gonçalves Ferreira, Manoel Otávio da Costa Rocha, Renan Pedra de Souza, Maria Auxiliadora Parreiras Martins\",\"doi\":\"10.2217/pgs-2023-0099\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Background:</b> Polymorphisms in the <i>CYP2C9</i>, <i>VKORC1</i>, <i>MDR1</i> and <i>APOE</i> genes may impact warfarin dose. <b>Aim:</b> To investigate the influence of sociodemographic, clinical factors and polymorphisms <i>*1</i>, <i>*2</i> and <i>*3</i> for <i>CYP2C9</i>, -1639G>A for <i>VKORC1</i>, 3435C>T for <i>MDR1</i>, and ϵ2, ϵ3 and ϵ4 for <i>APOE</i> genes on the mean weekly warfarin maintenance dose in adults. <b>Methods:</b> This cross-sectional study recruited a calculated sample of 315 patients in three anticoagulation clinics in Brazil. A model containing the variables significantly associated with warfarin dose was estimated. <b>Results:</b> The mean age of patients was 64.1 ± 13.1 years, with 173 (54.9%) women. Age, use of amiodarone, genotype <i>VKORC1</i> GA, genotype <i>VKORC1</i> AA, genotypes <i>CYP2C9*1/*2</i> or <i>*1/*3</i> and genotypes <i>CYP2C9*2/*2</i> or <i>*2/*3</i> or <i>*3/*3</i> were associated with a reduced warfarin dose. <b>Conclusion:</b> This study pointed out factors that could impact the management of oral anticoagulation.</p>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2023-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2217/pgs-2023-0099\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/9/13 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2217/pgs-2023-0099","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/9/13 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Influence of polymorphisms in CYP2C9, VKORC1, MDR1 and APOE genes on the warfarin maintenance dose in Brazilian patients.
Background: Polymorphisms in the CYP2C9, VKORC1, MDR1 and APOE genes may impact warfarin dose. Aim: To investigate the influence of sociodemographic, clinical factors and polymorphisms *1, *2 and *3 for CYP2C9, -1639G>A for VKORC1, 3435C>T for MDR1, and ϵ2, ϵ3 and ϵ4 for APOE genes on the mean weekly warfarin maintenance dose in adults. Methods: This cross-sectional study recruited a calculated sample of 315 patients in three anticoagulation clinics in Brazil. A model containing the variables significantly associated with warfarin dose was estimated. Results: The mean age of patients was 64.1 ± 13.1 years, with 173 (54.9%) women. Age, use of amiodarone, genotype VKORC1 GA, genotype VKORC1 AA, genotypes CYP2C9*1/*2 or *1/*3 and genotypes CYP2C9*2/*2 or *2/*3 or *3/*3 were associated with a reduced warfarin dose. Conclusion: This study pointed out factors that could impact the management of oral anticoagulation.
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Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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