慢性腰痛患者基底节的功能改变与核心稳定肌的自主激活有关:一项横断面研究。

IF 2.5 3区 医学 Q2 CLINICAL NEUROLOGY
Pain Research & Management Pub Date : 2023-08-31 eCollection Date: 2023-01-01 DOI:10.1155/2023/2028379
Chanjuan Zhang, Xi Chen, Yi Yin, Dongfeng Xie, Jing Luo, Yinan Ai, Wenfeng Zhan, Hongjun Kan, Shuxian Zhang, Guihua Jiang, Xiquan Hu
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引用次数: 0

摘要

目的:在慢性腰痛(CLBP)患者中一直观察到核心稳定肌的自主激活缺陷;然而,其潜在的神经机制尚不清楚。这项横断面研究旨在检验核心稳定肌的自主激活受损与基底神经节、丘脑、大脑皮层的结构和功能改变有关的假设,方法:我们获得了53名CLBP患者和67名健康对照的结构和静息状态功能磁共振成像(rs-fMRI)数据,并通过全脑分析估计了GMV改变区域的灰质体积(GMV)和功能有效连接(EC)的改变。通过超声成像评估这些患者的多裂肌(MF)和腹横肌(TrA)的自主激活。结果:与HC相比,双侧丘脑和尾状核的GMV显著降低,左额中回的GMV明显升高,右尾状核和双侧楔前叶之间的静息状态功能连接增加(体素水平p<0.005,高斯随机场校正p<0.05),这与双侧MF和TrA的自主激活显著相关(均<0.050)。结论:CLBP患者的灰质改变可能局限于负责感知、运动控制和情绪调节的区域。从基底神经节到默认模式网络的EC中断可能与核心稳定肌的自主激活受损有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Functional Alterations of the Basal Ganglia Are Associated with Voluntary Activation of the Core Stabilizing Muscles in Patients with Chronic Low Back Pain: A Cross-Sectional Study.

Functional Alterations of the Basal Ganglia Are Associated with Voluntary Activation of the Core Stabilizing Muscles in Patients with Chronic Low Back Pain: A Cross-Sectional Study.

Functional Alterations of the Basal Ganglia Are Associated with Voluntary Activation of the Core Stabilizing Muscles in Patients with Chronic Low Back Pain: A Cross-Sectional Study.

Functional Alterations of the Basal Ganglia Are Associated with Voluntary Activation of the Core Stabilizing Muscles in Patients with Chronic Low Back Pain: A Cross-Sectional Study.

Purpose: Deficits in voluntary activation of the core stabilizing muscles are consistently observed in patients with chronic low back pain (CLBP); however, the underlying neural mechanism remains unclear. This cross-sectional study aimed at testing the hypothesis that the impaired voluntary activation of core stabilizing muscles is associated with structural and functional alterations in the basal ganglia, thalamus, and cortex in patients with CLBP.

Methods: We obtained structural and resting-state functional magnetic resonance imaging (rs-fMRI) data from 53 patients with CLBP and 67 healthy controls and estimated the alterations in grey matter volume (GMV) and functional and effective connectivity (EC) of regions with altered GMV via whole brain analysis. The voluntary activation of the multifidus (MF) and transversus abdominis (TrA) was evaluated by ultrasound imaging in these patients.

Results: Compared with the HCs, they displayed a significant decrease in GMV in the bilateral thalamus and caudate nucleus, a significant increase in GMV in the left middle frontal gyrus, and increased resting-state functional connectivity between the right caudate nucleus and the bilateral precuneus (voxel-level p < 0.005, Gaussian random field-corrected p < 0.05). The patients also showed increased EC from the right caudate nucleus to the bilateral precuneus, which was significantly correlated with voluntary activation of the bilateral MF and TrA (all p < 0.050).

Conclusions: Grey matter alterations may be confined to regions responsible for perception, motor control, and emotion regulation in patients with CLBP. The interrupted EC from the basal ganglia to the default mode network might be involved in the impairment of voluntary activation of the core stabilizing muscles.

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来源期刊
Pain Research & Management
Pain Research & Management CLINICAL NEUROLOGY-
CiteScore
5.30
自引率
0.00%
发文量
109
审稿时长
>12 weeks
期刊介绍: Pain Research and Management is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of pain management. The most recent Impact Factor for Pain Research and Management is 1.685 according to the 2015 Journal Citation Reports released by Thomson Reuters in 2016.
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