一项在非洲血统的个体中检验慢性海洛因使用与端粒长度之间关系的试点研究。

IF 3.3 3区 心理学 Q1 BEHAVIORAL SCIENCES
Suky Martinez, Jermaine D. Jones
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引用次数: 0

摘要

背景:先前的研究表明,海洛因的使用与端粒长度缩短(TL)之间可能存在联系,端粒长度是细胞衰老和基因组稳定性的标志。我们试图通过研究非洲血统个体中TL和海洛因使用之间的关系来复制这些发现。方法:这项横断面研究在57名参与者中检测了TL,其中女性占17.5%;平均年龄48.0(±6.80)岁,非洲血统,患有阿片类药物使用障碍(OUD),平均海洛因使用持续时间为18.2(±10.7)年。定量聚合酶链式反应(qPCR)用于计算TL,即端粒重复拷贝数(T)与单个拷贝基因拷贝数(S)之间的比率。主要因变量是以千碱基对为单位测量的TL(T/S比率)。协变量包括海洛因使用年限和个性特征。结果:多元线性回归模型拟合良好,R2=0.265,F(7,49)=2.53,P10=5.77,R2=0.120。该系数的后验汇总为M=0.719(SD=0.278,95%可信区间[1.28,-0.163])。结论:与先前的研究相反,这些发现表明,在非洲血统的个体中,海洛因使用持续时间可能与TL没有显著关联,这突出表明需要更严格的研究来阐明这种关系的复杂性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A pilot study examining the relationship between chronic heroin use and telomere length among individuals of African ancestry

Background

Prior research has suggested a possible link between heroin use and shortened telomere length (TL), a marker of cellular aging and genomic stability. We sought to replicate these findings by examining the relationship between TL and heroin use among individuals of African ancestry.

Methods

This cross-sectional study examined TL among 57 participants [17.5 % female; mean age 48.0 (±6.80) years] of African ancestry with Opioid Use Disorder (OUD) and a mean heroin use duration of 18.2 (±10.7) years. Quantitative polymerase chain reaction (qPCR) was used to calculate TL as the ratio between telomere repeat copy number (T) and a single-copy gene, copy number (S). The primary dependent variable was TL (T/S Ratio) measured in kilobase pairs. Covariates included heroin use years and personality traits. Using a hybrid approach, multiple linear regression and Bayesian linear regression examined the association of chronological age, heroin use years and personality traits with TL.

Results

The multiple linear regression model fit the data well, R2 = 0.265, F(7,49) = 2.53, p < .026. Chronological age (β = −0.36, p = .017), neuroticism (β = 0.46, p = .044), and conscientiousness (β = 0.52, p = .040) were significant predictors of TL. Bayesian linear regression provided moderate support for the alternate hypothesis that chronological age and TL are associated, BF10 = 5.77, R2 = 0.120. The posterior summary of the coefficient was M = 0.719 (SD = 0.278, 95 % credible interval [−1.28, −0.163]).

Conclusions

Contrary to prior studies, these findings suggest that heroin use duration may not be significantly associated with TL among individuals of African ancestry, highlighting the need for more rigorous research to elucidate the complexity of this relationship.

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来源期刊
CiteScore
6.40
自引率
2.80%
发文量
122
审稿时长
38 days
期刊介绍: Pharmacology Biochemistry & Behavior publishes original reports in the areas of pharmacology and biochemistry in which the primary emphasis and theoretical context are behavioral. Contributions may involve clinical, preclinical, or basic research. Purely biochemical or toxicology studies will not be published. Papers describing the behavioral effects of novel drugs in models of psychiatric, neurological and cognitive disorders, and central pain must include a positive control unless the paper is on a disease where such a drug is not available yet. Papers focusing on physiological processes (e.g., peripheral pain mechanisms, body temperature regulation, seizure activity) are not accepted as we would like to retain the focus of Pharmacology Biochemistry & Behavior on behavior and its interaction with the biochemistry and neurochemistry of the central nervous system. Papers describing the effects of plant materials are generally not considered, unless the active ingredients are studied, the extraction method is well described, the doses tested are known, and clear and definite experimental evidence on the mechanism of action of the active ingredients is provided.
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