Adriano Antunes de Souza Araújo, Lucindo José Quintans-Júnior, Luana Heimfarth, Dulce Marta Schimieguel, Cristiane Bani Corrêa, Tatiana Rodrigues de Moura, Rafael Ciro Marques Cavalcante, Renata Grespan, Jullyana de Souza Siqueira Quintans, Danillo Menezes Dos Santos, Danilo Nobre da Silva, Yrna Lorena Matos de Oliveira, Mariana Nobre Farias de Franca, Marcílio da Conceição Silva, Darla Lorena Freitas de Sá, Fernanda Oliveira de Carvalho, Mércia Feitosa de Souza, Marco Aurélio de Oliveira Góes, Victor Santana Santos, Paulo Ricardo Martins-Filho
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A total of 16,547 individuals were tested using a rapid IgM-IgG antibody test and fluorescence immunoassay (FIA). Seroprevalence rates were presented according to age, sex, and geographic region. A comparative analysis was performed between the results obtained in July 2020 (peak of the first wave), August - November 2020 (end of the first wave), and February - March 2021 (beginning of the second wave). Seroprevalence rates in the three phases were estimated at 9.3% (95% CI 8.5-10.1), 12.0% (95% CI 11.2-12.9) and 15.4% (95% CI 14.5-16.4). At the end of the first wave, there was a rise in seroprevalence in the countryside (p < 0.001). At the beginning of the second wave, we found an increase in seroprevalence among women (p < 0.001), adults aged 20 to 59 years (p < 0.001), and the elderly (p < 0.001). In this phase, we found an increase in estimates both in metropolitan areas and in the countryside (p < 0.001). 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引用次数: 1
摘要
在这项以家庭为基础的血清流行病学调查中,我们分析了巴西东北部最贫困地区塞尔希佩州COVID-19大流行第一年SARS-CoV-2血清流行率的动态。采用快速IgM-IgG抗体试验和荧光免疫分析法(FIA)对16547人进行了检测。血清阳性率根据年龄、性别和地理区域呈现。对2020年7月(第一波高峰)、2020年8月至11月(第一波结束)和2021年2月至3月(第二波开始)获得的结果进行了比较分析。三个阶段的血清患病率估计为9.3% (95% CI 8.5-10.1), 12.0% (95% CI 11.2-12.9)和15.4% (95% CI 14.5-16.4)。在第一波浪潮结束时,农村地区的血清患病率有所上升
Dynamics of SARS-CoV-2 seroprevalence during the first year of the COVID-19 pandemic in the Northeast region of Brazil.
In this household-based seroepidemiological survey, we analyzed the dynamics of SARS-CoV-2 seroprevalence during the first year of the COVID-19 pandemic in Sergipe State, Northeast Brazil, the poorest region of the country. A total of 16,547 individuals were tested using a rapid IgM-IgG antibody test and fluorescence immunoassay (FIA). Seroprevalence rates were presented according to age, sex, and geographic region. A comparative analysis was performed between the results obtained in July 2020 (peak of the first wave), August - November 2020 (end of the first wave), and February - March 2021 (beginning of the second wave). Seroprevalence rates in the three phases were estimated at 9.3% (95% CI 8.5-10.1), 12.0% (95% CI 11.2-12.9) and 15.4% (95% CI 14.5-16.4). At the end of the first wave, there was a rise in seroprevalence in the countryside (p < 0.001). At the beginning of the second wave, we found an increase in seroprevalence among women (p < 0.001), adults aged 20 to 59 years (p < 0.001), and the elderly (p < 0.001). In this phase, we found an increase in estimates both in metropolitan areas and in the countryside (p < 0.001). This study showed an increase in SARS-CoV-2 seroprevalence over the first year of the pandemic, with approximately one in six people having anti-SARS-CoV-2 antibodies at the beginning of the second wave of COVID-19. Furthermore, our results suggest a rapid spread of COVID-19 from metropolitan areas to the countryside during the first months of the pandemic.
期刊介绍:
Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.