患者对心房颤动口服抗凝疗法出血副作用的担忧:KiCS-AF 多中心登记分析。

IF 2.9 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Ikuko Ueda, Shun Kohsaka, Nobuhiro Ikemura, Takehiro Kimura, Yoshinori Katsumata, Ryo Takemura, Masahiro Suzuki, Seiji Takatsuki, Daisuke Koide, Keiichi Fukuda
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引用次数: 0

摘要

目的:本研究旨在利用患者报告的结果来确定担心抗凝药物轻度至中度出血副作用的患者比例:2012年9月至2018年5月期间,我们在庆应义塾医院间心血管研究-心房颤动登记处的11个地点连续登记了3312名新诊断或转诊的心房颤动(房颤)患者。在这些患者中,有 2636 人(79.5%)在入院时服用口服抗凝药。通过心房颤动对生活质量的影响问卷(AFEQT),在有关出血副作用的七点量表中回答 "1:完全不烦恼 "或 "2:几乎不烦恼 "的患者被归为 "不担心 OAC "组,而回答 "3:有点烦恼 "至 "7:非常烦恼 "的患者被归为 "担心 OAC "组。根据基线分析,29.3%(n = 772)的患者 "担心 "出血副作用。关注口服抗凝剂(OAC)组与不关注口服抗凝剂组相比,女性和有房颤相关症状的患者比例更高(分别为 36.9% 对 29.8%,P < 0.0004 和 66.2% 对 56.7%,P < 0.0001)。CHADS2评分≥2分的患者组间具有可比性。在随访 1 年的 430 名患者中,继续关注 OAC 组(入组 1 年后)的比例为 41.6%。在基线和1年随访分析中,两组患者的达比加群、利伐沙班和阿哌沙班使用率相当:在所有接受抗凝治疗的房颤患者中,约有三分之一的患者担心短期和长期使用抗凝药物会导致出血。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Patient concern regarding bleeding side effects from oral anticoagulation therapy for atrial fibrillation: an analysis from the multicentre KiCS-AF registry.

Aims: The purpose of this study is to utilize patient-reported outcomes to determine the percentage of patients concerned about mild to moderate bleeding side effects of anticoagulants.

Methods and results: We consecutively enrolled 3312 newly diagnosed or referred patients for atrial fibrillation (AF) management from 11 sites within the Keio interhospital Cardiovascular Studies-Atrial Fibrillation registry between September 2012 and May 2018. Of these patients, 2636 (79.5%) were taking oral anticoagulants at enrollment. Using the Atrial Fibrillation Effect on Quality-of-life questionnaire (AFEQT), the patients who responded '1: not at all bothered' or '2: hardly bothered' on the seven-point scale regarding bleeding side effects were classified as the 'no OAC concern' group while those responding '3: a little bothered' to '7: extremely bothered' were classified as the 'OAC concern' group. On baseline analysis, 29.3% (n = 772) were 'concerned' about bleeding side effects. The proportion of women and patients with AF-related symptoms was higher in the oral anticoagulant (OAC) concern vs. no OAC concern group (36.9% vs. 29.8%, P < 0.0004 and 66.2% vs. 56.7%, P < 0.0001, respectively). The CHADS2 scores ≥ 2 were comparable between groups. Of the 430 patients in the 1-year follow-up analysis, the proportion of the continued OAC concern group (1 year from enrollment) was 41.6%. The dabigatran, rivaroxaban, and apixaban usage rates were comparable between the two groups in baseline and 1-year follow-up analysis.

Conclusion: Approximately one-third of all patients with AF on anticoagulant therapy were concerned regarding bleeding from short- and long-term anticoagulant use.

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来源期刊
European Journal of Cardiovascular Nursing
European Journal of Cardiovascular Nursing CARDIAC & CARDIOVASCULAR SYSTEMS-NURSING
CiteScore
5.10
自引率
10.30%
发文量
247
审稿时长
6-12 weeks
期刊介绍: The peer-reviewed journal of the European Society of Cardiology’s Council on Cardiovascular Nursing and Allied Professions (CCNAP) covering the broad field of cardiovascular nursing including chronic and acute care, cardiac rehabilitation, primary and secondary prevention, heart failure, acute coronary syndromes, interventional cardiology, cardiac care, and vascular nursing.
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