肥胖成人饮食炎症指数与全因死亡率之间的关系

IF 3.2 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Annals of Nutrition and Metabolism Pub Date : 2023-01-01 Epub Date: 2023-09-08 DOI:10.1159/000533380

Xin Zheng, Yi-Zhong Ge, Guo-Tian Ruan, Shi-Qi Lin, Yue Chen, Chen-An Liu, Hai-Lun Xie, Meng-Meng Song, Tong Liu, Zi-Wen Wang, Jin-Yu Shi, He-Yang Zhang, Ming Yang, Xiao-Yue Liu, Li Deng, Han-Ping Shi

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引用次数: 0

摘要

膳食炎症指数(DII)与许多慢性非传染性疾病有关。先前的研究表明，促炎性DII类型与腹部和单纯性肥胖有关。然而，DII与腹部肥胖和单纯超重或肥胖患者死亡率之间的关系尚不清楚。方法:我们使用2007年至2018年美国国家健康与营养检查调查(NHANES)的数据。DII + gt;0 (DII阳性)定义为促炎饮食。用限制性三次样条曲线描述DII与全因死亡率之间的趋势。然后，我们使用Cox回归分析检查了DII与不同体型的全因死亡率之间的关系，并调查了性别之间的差异。最后，探讨了全身性炎症的介导作用。结果:促炎饮食增加了腹部肥胖成人的全因死亡率(aHR: 1.31, 95%可信区间[CI]: 1.11-1.54;p & lt;0.001)和单纯超重或肥胖(aHR: 1.30, 95% CI: 1.11-1.53;p & lt;0.001)。此外，最具促炎性的DII使死亡风险增加43%(风险比[HR]: Q4 vs. Q1 = 1.43, 95% CI = 1.14-1.79;P = 0.002;p代表趋势= 0.003)和39% (HR: Q4 vs. Q1 = 1.39, 95% CI = 1.13-1.74;P = 0.003;P为趋势= 0.009)，分别为腹部肥胖和单纯超重或肥胖的参与者。然而，这种关联在正常体型的参与者中不存在。与男性相比，女性抵抗了促炎饮食的影响。中介分析表明，白细胞和中性粒细胞是DII与全因死亡率之间关系的中介因子(p <0.001)。结论:促炎饮食与腹部肥胖和单纯超重或肥胖的成人全因死亡率相关，且这种影响在男性和女性之间有所不同。全身性炎症可能介导DII与全因死亡率之间的关联。

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Association between the Dietary Inflammatory Index and All-Cause Mortality in Adults with Obesity.

Introduction: The dietary inflammatory index (DII) is associated with numerous chronic noncommunicable diseases. Previous studies have shown that the pro-inflammatory DII categories are associated with abdominal and simple obesity. However, the association between DII and mortality in patients with abdominal obesity and simple overweight or obesity remains unclear.

Methods: We used data from the US National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018. A DII >0 (positive DII) was defined as a pro-inflammatory diet. A restricted cubic spline curve was used to describe the trend between DII and all-cause mortality. We then examined the association between DII and all-cause mortality in different body types using a Cox regression analysis and investigated the differences between sexes. Finally, the mediating effects of systemic inflammation were explored.

Results: A pro-inflammatory diet increased all-cause mortality in adults with abdominal obesity (aHR: 1.31, 95% confidence interval [CI]: 1.11-1.54; p < 0.001) and with simple overweight or obesity (aHR: 1.30, 95% CI: 1.11-1.53; p < 0.001). In addition, the most pro-inflammatory DII increased the risk of mortality by 43% (hazard ratio [HR]: Q4 vs. Q1 = 1.43, 95% CI = 1.14-1.79; p = 0.002; p for trend = 0.003) and 39% (HR: Q4 vs. Q1 = 1.39, 95% CI = 1.13-1.74; p = 0.003; p for trend = 0.009) in participants with abdominal obesity and with simple overweight or obesity, respectively. However, this association was not present in normal-sized participants. Compared with men, women resisted the effects of a pro-inflammatory diet. Mediation analysis showed that white blood cell and neutrophil were mediators of the association between DII and all-cause mortality (p < 0.001).

Conclusion: A pro-inflammatory diet is associated with all-cause mortality in adults with abdominal obesity and simple overweight or obesity, and this effect differs between men and women. Systemic inflammation may mediate the association between DII and all-cause mortality.

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来源期刊

Annals of Nutrition and Metabolism 医学-内分泌学与代谢

CiteScore

6.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Annals of Nutrition and Metabolism'' is a leading international peer-reviewed journal for sharing information on human nutrition, metabolism and related fields, covering the broad and multidisciplinary nature of science in nutrition and metabolism. As the official journal of both the International Union of Nutritional Sciences (IUNS) and the Federation of European Nutrition Societies (FENS), the journal has a high visibility among both researchers and users of research outputs, including policy makers, across Europe and around the world.