Bana Shriky, Aryane Alves Vigato, Anderson Ferreira Sepulveda, Ian Pompermayer Machado, Daniele Ribeiro de Araujo
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引用次数: 0
摘要
基于 Poloxamers 或 Pluronics® 的纳米凝胶是开发给药系统最常用的基质之一。由于它们具有热致伸缩性和柔韧的机械特性,因此可以加入多种分子,包括药物、生物大分子、脂质衍生物、聚合物以及金属、聚合物或脂质纳米载体。热凝胶机理是由胶束的形成及其在温度、渗透压和添加剂等微环境条件下的相组织(层状、六角形、立方体)自组装驱动的。然后,不同的生物物理技术被用于研究从机制到优先成分取向和组织的结构转变。由于基于聚乳酸的药物制剂的设计是由聚合物类型的选择驱动的,同时还要考虑其物理化学特性,因此还需要强调聚合物基质的固有因素会受到添加剂的强烈影响,以及添加剂如何决定纳米凝胶的生物制药特性,如生物粘附性、药物负载、表面相互作用行为、溶解和释放速率控制。在这篇综述中,我们讨论了用于表征这些系统的三种主要生物物理技术--散射技术(小角 X 射线和中子散射)、流变学和傅立叶变换红外吸收光谱(FTIR)--的一般适用性,并将它们与超分子结构联系起来,深入探讨了如何配制有效的治疗给药系统:在线版本包含补充材料,可查阅 10.1007/s12551-023-01093-2。
Poloxamer-based nanogels as delivery systems: how structural requirements can drive their biological performance?
Poloxamers or Pluronics®-based nanogels are one of the most used matrices for developing delivery systems. Due to their thermoresponsive and flexible mechanical properties, they allowed the incorporation of several molecules including drugs, biomacromolecules, lipid-derivatives, polymers, and metallic, polymeric, or lipid nanocarriers. The thermogelling mechanism is driven by micelles formation and their self-assembly as phase organizations (lamellar, hexagonal, cubic) in response to microenvironmental conditions such as temperature, osmolarity, and additives incorporated. Then, different biophysical techniques have been used for investigating those structural transitions from the mechanisms to the preferential component's orientation and organization. Since the design of PL-based pharmaceutical formulations is driven by the choice of the polymer type, considering its physico-chemical properties, it is also relevant to highlight that factors inherent to the polymeric matrix can be strongly influenced by the presence of additives and how they are able to determine the nanogels biopharmaceuticals properties such as bioadhesion, drug loading, surface interaction behavior, dissolution, and release rate control. In this review, we discuss the general applicability of three of the main biophysical techniques used to characterize those systems, scattering techniques (small-angle X-ray and neutron scattering), rheology and Fourier transform infrared absorption spectroscopy (FTIR), connecting their supramolecular structure and insights for formulating effective therapeutic delivery systems.
Supplementary information: The online version contains supplementary material available at 10.1007/s12551-023-01093-2.
期刊介绍:
Biophysical Reviews aims to publish critical and timely reviews from key figures in the field of biophysics. The bulk of the reviews that are currently published are from invited authors, but the journal is also open for non-solicited reviews. Interested authors are encouraged to discuss the possibility of contributing a review with the Editor-in-Chief prior to submission. Through publishing reviews on biophysics, the editors of the journal hope to illustrate the great power and potential of physical techniques in the biological sciences, they aim to stimulate the discussion and promote further research and would like to educate and enthuse basic researcher scientists and students of biophysics. Biophysical Reviews covers the entire field of biophysics, generally defined as the science of describing and defining biological phenomenon using the concepts and the techniques of physics. This includes but is not limited by such areas as: - Bioinformatics - Biophysical methods and instrumentation - Medical biophysics - Biosystems - Cell biophysics and organization - Macromolecules: dynamics, structures and interactions - Single molecule biophysics - Membrane biophysics, channels and transportation