保持形状并保持运动:MLL作为Rho GTP酶的新转录调节因子出现。

Q2 Biochemistry, Genetics and Molecular Biology
Akash Chinchole, Shreyta Gupta, Shweta Tyagi
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引用次数: 0

摘要

RhoA、Rac1和CDC42是小G蛋白,在调节各种细胞过程中发挥着至关重要的作用,如肌动蛋白细胞骨架的形成、细胞形状和细胞迁移。我们最近的研究结果表明,MLL负责维持这些小Rho GTP酶的平衡。MLL耗竭影响Rho GTP酶的稳定性,导致其蛋白质水平降低和活性丧失。这些变化表现为细胞形状异常和肌动蛋白细胞骨架断裂,导致细胞扩散和迁移减少。有趣的是,它们的伴侣蛋白RhoGDI1(而不是Rho GTP酶)受到MLL的直接转录调控。在这里,我们评论了这些观察结果对Rho-GTPases蛋白网络信号传导的可能影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

To stay in shape and keep moving: MLL emerges as a new transcriptional regulator of Rho GTPases.

To stay in shape and keep moving: MLL emerges as a new transcriptional regulator of Rho GTPases.

To stay in shape and keep moving: MLL emerges as a new transcriptional regulator of Rho GTPases.

To stay in shape and keep moving: MLL emerges as a new transcriptional regulator of Rho GTPases.

RhoA, Rac1 and CDC42 are small G proteins that play a crucial role in regulating various cellular processes, such as the formation of actin cytoskeleton, cell shape and cell migration. Our recent results suggest that MLL is responsible for maintaining the balance of these small Rho GTPases. MLL depletion affects the stability of Rho GTPases, leading to a decrease in their protein levels and loss of activity. These changes manifest in the form of abnormal cell shape and disrupted actin cytoskeleton, resulting in reduced cell spreading and migration. Interestingly, their chaperone protein RhoGDI1 but not the Rho GTPases, is under the direct transcriptional regulation of MLL. Here, we comment on the possible implications of these observations on the signalling by Rho GTPases protein network.

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来源期刊
Small GTPases
Small GTPases Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
6.10
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0.00%
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6
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