随机对照试验对药物需求的影响:来自标签外抗癌药物的证据

IF 3.4 2区经济学 Q1 ECONOMICS

Journal of Health Economics Pub Date : 2023-07-01 DOI:10.1016/j.jhealeco.2023.102779

Rebecca McKibbin

{"title":"随机对照试验对药物需求的影响:来自标签外抗癌药物的证据","authors":"Rebecca McKibbin","doi":"10.1016/j.jhealeco.2023.102779","DOIUrl":null,"url":null,"abstract":"<div><p>This paper investigates the effect of scientific information from randomized controlled clinical trials<span> (RCTs) on the demand for off-label uses of cancer drugs. This is a unique setting where demand for a drug for a specific use is observable both before and after the first RCT results are released. Using variation in the timing of RCTs across off-label uses of drugs, I find that demand responds asymmetrically to the trial results based on the statistical significance of the clinically relevant endpoint. When this endpoint is statistically significant, there is a large and immediate increase in demand. When this end point is not statistically significant, physicians are relatively slow to abandon use of the drug.</span></p></div>","PeriodicalId":50186,"journal":{"name":"Journal of Health Economics","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effect of RCTs on drug demand: Evidence from off-label cancer drugs\",\"authors\":\"Rebecca McKibbin\",\"doi\":\"10.1016/j.jhealeco.2023.102779\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>This paper investigates the effect of scientific information from randomized controlled clinical trials<span> (RCTs) on the demand for off-label uses of cancer drugs. This is a unique setting where demand for a drug for a specific use is observable both before and after the first RCT results are released. Using variation in the timing of RCTs across off-label uses of drugs, I find that demand responds asymmetrically to the trial results based on the statistical significance of the clinically relevant endpoint. When this endpoint is statistically significant, there is a large and immediate increase in demand. When this end point is not statistically significant, physicians are relatively slow to abandon use of the drug.</span></p></div>\",\"PeriodicalId\":50186,\"journal\":{\"name\":\"Journal of Health Economics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Health Economics\",\"FirstCategoryId\":\"96\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0167629623000565\",\"RegionNum\":2,\"RegionCategory\":\"经济学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ECONOMICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Health Economics","FirstCategoryId":"96","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167629623000565","RegionNum":2,"RegionCategory":"经济学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ECONOMICS","Score":null,"Total":0}

引用次数: 0

摘要

本文研究了随机对照临床试验的科学信息对癌症药物非标签使用需求的影响。这是一个独特的环境，在第一次随机对照试验结果公布之前和之后，都可以观察到对特定用途药物的需求。利用随机对照试验在标签外药物使用中的时间变化，我发现基于临床相关终点的统计显著性，需求对试验结果的反应是不对称的。当这个终点具有统计学意义时，需求会立即大幅增加。当这个终点在统计上不显著时，医生放弃使用该药物的速度相对较慢。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The effect of RCTs on drug demand: Evidence from off-label cancer drugs

This paper investigates the effect of scientific information from randomized controlled clinical trials (RCTs) on the demand for off-label uses of cancer drugs. This is a unique setting where demand for a drug for a specific use is observable both before and after the first RCT results are released. Using variation in the timing of RCTs across off-label uses of drugs, I find that demand responds asymmetrically to the trial results based on the statistical significance of the clinically relevant endpoint. When this endpoint is statistically significant, there is a large and immediate increase in demand. When this end point is not statistically significant, physicians are relatively slow to abandon use of the drug.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Health Economics 医学-卫生保健

CiteScore

6.10

自引率

2.90%

发文量

审稿时长

49 days

期刊介绍： This journal seeks articles related to the economics of health and medical care. Its scope will include the following topics: Production and supply of health services; Demand and utilization of health services; Financing of health services; Determinants of health, including investments in health and risky health behaviors; Economic consequences of ill-health; Behavioral models of demanders, suppliers and other health care agencies; Evaluation of policy interventions that yield economic insights; Efficiency and distributional aspects of health policy; and such other topics as the Editors may deem appropriate.