人工智能在癌症药物发现和靶点识别中的作用。

IF 2.8 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Vishal Sharma, Amit Singh, Sanjana Chauhan, Pramod Kumar Sharma, Shubham Chaudhary, Astha Sharma, Omji Porwal, Neeraj Kumar Fuloria
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引用次数: 0

摘要

药物研发(DDD)是一个高度复杂的过程,需要在每个阶段进行精确监控和大量数据分析。此外,药物研发过程既耗时又昂贵。为了解决这些问题,可以使用人工智能(AI)技术,以便在有限的时间内对大量数据集进行快速、精确的分析。癌症疾病的病理生理学非常复杂,需要进行大量研究才能发现和开发出新型药物。药物发现和开发过程的第一阶段是确定靶点。细胞结构和分子功能非常复杂,因为有大量的分子在不断发挥作用,扮演着不同的角色。此外,科学家们还在不断发现新的细胞机制和分子,从而扩大了潜在靶点的范围。准确识别正确的靶点是制定治疗策略的关键一步。目前,各种形式的人工智能,如机器学习、基于神经的学习、深度学习和基于网络的学习,正在应用于应用程序、在线服务和数据库中。这些技术有助于识别和验证目标,最终促进项目的成功。本综述重点介绍在癌症药物发现和靶点识别领域使用的人工智能数据库的不同类型和子类别。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of Artificial Intelligence in Drug Discovery and Target Identification in Cancer.

Drug discovery and development (DDD) is a highly complex process that necessitates precise monitoring and extensive data analysis at each stage. Furthermore, the DDD process is both timeconsuming and costly. To tackle these concerns, artificial intelligence (AI) technology can be used, which facilitates rapid and precise analysis of extensive datasets within a limited timeframe. The pathophysiology of cancer disease is complicated and requires extensive research for novel drug discovery and development. The first stage in the process of drug discovery and development involves identifying targets. Cell structure and molecular functioning are complex due to the vast number of molecules that function constantly, performing various roles. Furthermore, scientists are continually discovering novel cellular mechanisms and molecules, expanding the range of potential targets. Accurately identifying the correct target is a crucial step in the preparation of a treatment strategy. Various forms of AI, such as machine learning, neural-based learning, deep learning, and network-based learning, are currently being utilised in applications, online services, and databases. These technologies facilitate the identification and validation of targets, ultimately contributing to the success of projects. This review focuses on the different types and subcategories of AI databases utilised in the field of drug discovery and target identification for cancer.

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来源期刊
Current drug delivery
Current drug delivery PHARMACOLOGY & PHARMACY-
CiteScore
5.10
自引率
4.20%
发文量
170
期刊介绍: Current Drug Delivery aims to publish peer-reviewed articles, research articles, short and in-depth reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves. The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance. The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.
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