伴有MEIS1:：NCOA2融合的骨内梭形细胞横纹肌肉瘤——病例报告及大量临床随访和文献复习。

IF 1.8 4区医学 Q3 ONCOLOGY

Cancer Investigation Pub Date : 2023-09-01 Epub Date: 2023-09-06 DOI:10.1080/07357907.2023.2255668

Benjamin F Smith, Yee-Cheen Doung, Brooke Beckett, Christopher L Corless, Lara E Davis, Jessica L Davis

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引用次数: 0

摘要

梭形细胞/硬化性横纹肌肉瘤（SSRMS）是一种临床病理和分子异质性疾病。已在骨内SSRMS中鉴定出基因融合，主要由EWSR1/FUS:：TFCP2和MEIS1:：NCOA2组成。前者通常遵循积极的临床过程；后者的临床随访有限。我们在此报告一例非常罕见的骨内SSRMS与MEIS1:：NCOA2基因融合的新病例，包括详细的治疗过程和52 临床随访数月。具有MEIS1:：NCOA2基因融合的SSRMS在生物学上与其他骨内SSRMS不同，其病程以局部复发为特征，迄今为止很少有转移报告。

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Intraosseous Spindle Cell Rhabdomyosarcoma with MEIS1::NCOA2 Fusion - Case Report with Substantial Clinical Follow-up and Review of the Literature.

Spindle cell/sclerosing rhabdomyosarcoma (SSRMS) is a clinicopathologically and molecularly heterogeneous disease. Gene fusions have been identified in intraosseous SSRMS, consisting predominantly of EWSR1/FUS::TFCP2 and MEIS1::NCOA2. The former often follow an aggressive clinical course; there is limited clinical follow-up available for the latter. We report here a new case of the very rare intraosseous SSRMS with MEIS1::NCOA2 gene fusion and include the detailed treatment course and 52 months of clinical follow-up. SSRMS with MEIS1::NCOA2 gene fusion appears biologically distinct from other intraosseous SSRMS, following a course characterized by local recurrence with rare reports of metastasis to date.

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来源期刊

Cancer Investigation 医学-肿瘤学

CiteScore

3.80

自引率

4.20%

发文量

审稿时长

8.5 months

期刊介绍： Cancer Investigation is one of the most highly regarded and recognized journals in the field of basic and clinical oncology. It is designed to give physicians a comprehensive resource on the current state of progress in the cancer field as well as a broad background of reliable information necessary for effective decision making. In addition to presenting original papers of fundamental significance, it also publishes reviews, essays, specialized presentations of controversies, considerations of new technologies and their applications to specific laboratory problems, discussions of public issues, miniseries on major topics, new and experimental drugs and therapies, and an innovative letters to the editor section. One of the unique features of the journal is its departmentalized editorial sections reporting on more than 30 subject categories covering the broad spectrum of specialized areas that together comprise the field of oncology. Edited by leading physicians and research scientists, these sections make Cancer Investigation the prime resource for clinicians seeking to make sense of the sometimes-overwhelming amount of information available throughout the field. In addition to its peer-reviewed clinical research, the journal also features translational studies that bridge the gap between the laboratory and the clinic.