中国东部济宁汉族人群16个x染色体STRs的法医学特征及多态性分析

IF 1.2 4区 医学 Q2 ANTHROPOLOGY
Yequan Wang, Ao Gao, Xiudi Hou, Qi Liu, Dan Wang, Zhen Dang
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引用次数: 0

摘要

背景:x染色体短串联重复序列(X-STRs)是法医和亲属研究中分析常染色体标记的有用补充方法;这些标记在许多人群中没有很好地表征。目的:研究济宁汉族人群中16个x - str的群体遗传多态性和法医学鉴定,并分析其与其他中国人群的遗传关系。对象和方法:从济宁汉族人群527例无亲缘关系个体中获得16个X-STR基因座的等位基因频率。采用系统发育树、主成分分析和多维标度法对济宁汉和另外10个参考群体进行了群体遗传分析。结果:共检测到149个等位基因,频率范围为0.0013 ~ 0.8242。男性和女性的综合歧视力分别为0.999999997194774和0.99999999999999995。合并MEC kr格、MECKishida、MECDesmarais和MECDesmarais Duos值分别为0.999974632649096、0.999999976997582、0.99999999977013201和0.999993755768423。在具有相似民族或地理来源的人群中,我们发现了相对较高的遗传同质性,并且在济宁汉族和北京汉族人群之间存在密切的关系。结论:16个X-STR基因座在济宁汉族人群中具有高度多态性,为法医学和群体遗传学研究提供了有益的信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Forensic characterisation and polymorphism analysis of 16 X-chromosomal STRs in the Jining Han population in Eastern China.

Background: X-chromosomal short tandem repeats (X-STRs) are a useful supplementary approach to analysing autosomal markers in forensics and kinship studies; such markers are not well-characterised in many populations.

Aim: To investigate population genetic polymorphism and forensic characterisation of 16 X-STRs in the Jining Han population, and analyse genetic relationships with other Chinese populations.

Subjects and methods: Allele frequencies for 16 X-STR loci were obtained from a sample set of 527 unrelated individuals from the Jining Han population. Population genetic analyses of Jining Han and another 10 reference populations were conducted using phylogenetic tree, principal component analysis and multidimensional scaling.

Results: We detected 149 alleles, with frequencies ranging from 0.0013 to 0.8242. The combined powers of discrimination in males and females were 0.999999997194774 and 0.999999999999995, respectively. The combined mean exclusion change (MEC)Krüger, MECKishida, MECDesmarais, and MECDesmarais Duos values were 0.999974632649096, 0.999999976997582, 0.999999977013201, and 0.999993755768423, respectively. We detected relatively high genetic homogeneity in populations with similar ethnic or geographic origins, and a close relationship between the Jining Han and Beijing Han populations.

Conclusions: The present findings indicate that the 16 X-STR loci examined are highly polymorphic in the Han population of Jining, providing useful information for forensic science and population genetics studies.

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来源期刊
Annals of Human Biology
Annals of Human Biology 生物-公共卫生、环境卫生与职业卫生
CiteScore
3.40
自引率
5.90%
发文量
46
审稿时长
1 months
期刊介绍: Annals of Human Biology is an international, peer-reviewed journal published six times a year in electronic format. The journal reports investigations on the nature, development and causes of human variation, embracing the disciplines of human growth and development, human genetics, physical and biological anthropology, demography, environmental physiology, ecology, epidemiology and global health and ageing research.
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