Mohammad Reza Jafari Nakhjavani, Amir Ghorbanihaghjo, Aida Malek Mahdavi, Negin Nemati, Nadereh Rashtchizadeh, Sima Abedi Azar, Alireza Khabbazi
{"title":"血清α-Klotho水平与behet病的关系","authors":"Mohammad Reza Jafari Nakhjavani, Amir Ghorbanihaghjo, Aida Malek Mahdavi, Negin Nemati, Nadereh Rashtchizadeh, Sima Abedi Azar, Alireza Khabbazi","doi":"10.1093/labmed/lmac146","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Endothelial dysfunction (ED) has a well-known role in promoting vascular inflammation in Behçet disease (BD). α-klotho is involved in regulation of endothelial function, and its reduction has been reported to be associated with ED.</p><p><strong>Objective: </strong>To assess serum α-klotho in patients with BD, compared with healthy control individuals.</p><p><strong>Methods: </strong>In a cross-sectional study, 55 patients with BD and 30 age- and sex-matched healthy controls were enrolled, and their serum levels of α-klotho were measured.</p><p><strong>Results: </strong>Common clinical symptoms in patients with BD were oral aphthous ulcers, uveitis, and genital ulcers. Median (IQR) serum α-klotho levels in the BD and control groups were 0.30 (0.20-0.70) and 1.00 (0.70-2.52) ng/mL, respectively. The difference was statistically significant (P = .005). No significant correlation was observed between serum α-klotho and age (r = 0.194; P = .14). Serum α-klotho levels in patients with uveitis were significantly lower.</p><p><strong>Conclusion: </strong>α-klotho may have a role in the pathogenesis of ED and is a potential biomarker for uveitis in BD.</p>","PeriodicalId":17951,"journal":{"name":"Laboratory medicine","volume":"54 5","pages":"469-472"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between Serum α-Klotho Levels and Behçet Disease.\",\"authors\":\"Mohammad Reza Jafari Nakhjavani, Amir Ghorbanihaghjo, Aida Malek Mahdavi, Negin Nemati, Nadereh Rashtchizadeh, Sima Abedi Azar, Alireza Khabbazi\",\"doi\":\"10.1093/labmed/lmac146\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Endothelial dysfunction (ED) has a well-known role in promoting vascular inflammation in Behçet disease (BD). α-klotho is involved in regulation of endothelial function, and its reduction has been reported to be associated with ED.</p><p><strong>Objective: </strong>To assess serum α-klotho in patients with BD, compared with healthy control individuals.</p><p><strong>Methods: </strong>In a cross-sectional study, 55 patients with BD and 30 age- and sex-matched healthy controls were enrolled, and their serum levels of α-klotho were measured.</p><p><strong>Results: </strong>Common clinical symptoms in patients with BD were oral aphthous ulcers, uveitis, and genital ulcers. Median (IQR) serum α-klotho levels in the BD and control groups were 0.30 (0.20-0.70) and 1.00 (0.70-2.52) ng/mL, respectively. The difference was statistically significant (P = .005). No significant correlation was observed between serum α-klotho and age (r = 0.194; P = .14). Serum α-klotho levels in patients with uveitis were significantly lower.</p><p><strong>Conclusion: </strong>α-klotho may have a role in the pathogenesis of ED and is a potential biomarker for uveitis in BD.</p>\",\"PeriodicalId\":17951,\"journal\":{\"name\":\"Laboratory medicine\",\"volume\":\"54 5\",\"pages\":\"469-472\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-09-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Laboratory medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/labmed/lmac146\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Laboratory medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/labmed/lmac146","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Association between Serum α-Klotho Levels and Behçet Disease.
Background: Endothelial dysfunction (ED) has a well-known role in promoting vascular inflammation in Behçet disease (BD). α-klotho is involved in regulation of endothelial function, and its reduction has been reported to be associated with ED.
Objective: To assess serum α-klotho in patients with BD, compared with healthy control individuals.
Methods: In a cross-sectional study, 55 patients with BD and 30 age- and sex-matched healthy controls were enrolled, and their serum levels of α-klotho were measured.
Results: Common clinical symptoms in patients with BD were oral aphthous ulcers, uveitis, and genital ulcers. Median (IQR) serum α-klotho levels in the BD and control groups were 0.30 (0.20-0.70) and 1.00 (0.70-2.52) ng/mL, respectively. The difference was statistically significant (P = .005). No significant correlation was observed between serum α-klotho and age (r = 0.194; P = .14). Serum α-klotho levels in patients with uveitis were significantly lower.
Conclusion: α-klotho may have a role in the pathogenesis of ED and is a potential biomarker for uveitis in BD.
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