老年人 DRESS 综合征的特征:55 例患者的对比研究

IF 4 3区 医学 Q1 DERMATOLOGY
Dermatitis Pub Date : 2024-01-01 Epub Date: 2023-09-05 DOI:10.1089/derm.2022.0032
Emna Bahloul, Khaoula Trimeche, Khadija Sellami, Fatma Hammami, Faten Hayder, Rim Chaabouni, Meriem Amouri, Abderrahmen Masmoudi, Madiha Mseddi, Sonia Boudeya, Hamida Turki
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引用次数: 0

摘要

背景:伴有嗜酸性粒细胞增多和全身症状的药物反应(DRESS)是一种罕见的药物反应,以皮疹、嗜酸性粒细胞增多和器官受累为特征。研究目的我们的目的是重点研究老年人 DRESS 的临床和流行病学特征,并确定可归罪的药物。方法:这是一项回顾性研究:这是一项回顾性研究,研究对象包括因 DRESS 住院且 RegiSCAR≥4 的患者。研究对象按年龄分为两组:65 岁或以上(G1)和结果:我们共纳入了 55 名患者(30.9% 为 G1 组,69.1% 为 G2 组)。两组患者的皮肤表现相当。淋巴结病在 G1 组较少见,差异有统计学意义(P = 0.012)。肾功能损害在老年人中更为常见,差异有统计学意义(P = 0.005)。老年组的 DRESS 与败血症的发生有显著相关性(P = 0.008)。别嘌呤醇是 G1 中与 DRESS 相关的最常见元凶(P = 0.001)。两组患者的复发和复发率相当(P = 0.71)。结论老年人的 DRESS 与并发症的高风险相关,主要是肾脏受累和败血症。别嘌醇是罪责最大的药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Characteristics of DRESS Syndrome in the Elderly: A Comparative Study of 55 Patients.

Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare drug reaction characterized by a skin rash, eosinophilia, and organ involvement. Objective: Our purpose is to focus on the clinical and epidemiological characteristics of DRESS in the elderly and to identify the incriminated drugs. Methods: This is a retrospective study including patients, hospitalized for DRESS with a RegiSCAR ≥4. The population was divided into 2 groups according to age: 65 years or older (G1) and <65 years (G2). The statistical study was performed using the comparative and multivariate analysis. Results: We included 55 patients (30.9% G1 and 69.1% G2). Skin manifestations were comparable in both groups. Lymphadenopathy was less common in G1 with a statistically significant difference (P = 0.012). Renal impairment was more frequent in the elderly with a statistically significant result (P = 0.005). DRESS in the elderly group was significantly associated with the occurrence of sepsis (P = 0.008). Allopurinol was the most common culprit associated with DRESS in G1 (P = 0.001). Relapses and recurrences were comparable in both groups (P = 0.71). Conclusions: DRESS in the elderly is associated with a high risk of complications, mainly kidney involvement and sepsis. Allopurinol is the most incriminated drug.

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来源期刊
Dermatitis
Dermatitis 医学-皮肤病学
CiteScore
5.30
自引率
11.50%
发文量
251
审稿时长
>12 weeks
期刊介绍: Dermatitis is owned by the American Contact Dermatitis Society and is the home journal of 4 other organizations, namely Societa Italiana di Dermatologica Allergologica Professionale e Ambientale, Experimental Contact Dermatitis Research Group, International Contact Dermatitis Research Group, and North American Contact Dermatitis Group. Dermatitis focuses on contact, atopic, occupational, and drug dermatitis, and welcomes manuscript submissions in these fields, with emphasis on reviews, studies, reports, and letters. Annual sections include Contact Allergen of the Year and Contact Allergen Alternatives, for which papers are chosen or invited by the respective section editor. Other sections unique to the journal are Pearls & Zebras, Product Allergen Watch, and news, features, or meeting abstracts from participating organizations.
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