日粮溶菌酶改善断奶仔猪生长性能和肠道屏障功能

IF 6.3
Yuying Wu , Bei Cheng , Longxiang Ji , Xiangyun Lv , Yingying Feng , Liu’an Li , Xin Wu
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引用次数: 0

摘要

溶菌酶(LZ)是一种纯天然、无污染、非特异性的免疫因子,对动物的健康发育具有有益作用。研究了LZ对断奶仔猪生长性能和肠道屏障的影响。将48头断奶仔猪(Landrace×Yorkshire,22日龄)随机分为对照组(基础日粮)和LZ组(0.1%LZ日粮),共19 d。结果表明,LZ能显著提高平均日增重(ADG,P<;0.05)和平均日采食量(ADFI,P>;0.05)。LZ还能改善肠道形态,显著增加空肠occludin的表达(P<;05),LZ下调白细胞介素-1β(IL-1β,P<;0.05)和肿瘤坏死因子-α(TNF-α,P<!0.05)的表达,并抑制核因子-κB信号通路中基因的表达。更重要的是,肠道菌群分析显示,LZ在门水平上增加了厚壁菌门的丰度(P<;0.05)和厚壁菌与拟杆菌门的比例(P=0.09),在属水平上增加梭状芽孢杆菌_sensustricto_1的丰度(P/lt;0.05;)并降低了Olsenella和Prevotella的丰度(P<;0.05)。总之,本研究证明LZ能有效改善断奶仔猪的生长性能,减轻炎症,改善肠道屏障功能。这些发现为LZ在生猪生产中的应用提供了重要的理论依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Dietary lysozyme improves growth performance and intestinal barrier function of weaned piglets

Dietary lysozyme improves growth performance and intestinal barrier function of weaned piglets

Dietary lysozyme improves growth performance and intestinal barrier function of weaned piglets

Dietary lysozyme improves growth performance and intestinal barrier function of weaned piglets

Lysozyme (LZ) is a purely natural, nonpolluting and nonspecific immune factor, which has beneficial effects on the healthy development of animals. In this study, the influences of LZ on the growth performance and intestinal barrier of weaned piglets were studied. A total of 48 weaned piglets (Landrace × Yorkshire, 22 d old) were randomly divided into a control group (basal diet) and a LZ group (0.1% LZ diet) for 19 d. The results showed that LZ could significantly improve the average daily gain (ADG, P < 0.05) and average daily feed intake (ADFI, P < 0.05). LZ also improved the intestinal morphology and significantly increased the expression of occludin in the jejunum (P < 0.05). In addition, LZ down-regulated the expression of interleukin-1β (IL-1β, P < 0.05) and tumor necrosis factor-α (TNF-α, P < 0.05), and inhibited the expression of the genes in the nuclear factor-k-gene binding (NF-κB, P < 0.05) signaling pathway. More importantly, the analysis of intestinal flora showed LZ increased the abundance of Firmicutes (P < 0.05) and the ratio of Firmicutes to Bacteroidota (P = 0.09) at the phylum level, and increased the abundance of Clostridium_sensu_stricto_1 (P < 0.05) and reduced the abundance of Olsenella and Prevotella (P < 0.05) at the genus level. In short, this study proved that LZ could effectively improve the growth performance, relieve inflammation and improve the intestinal barrier function of weaned piglets. These findings provided an important theoretical basis for the application of LZ in pig production.

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来源期刊
Animal Nutrition
Animal Nutrition Animal Science and Zoology
CiteScore
9.70
自引率
0.00%
发文量
542
审稿时长
65 days
期刊介绍: Animal Nutrition encompasses the full gamut of animal nutritional sciences and reviews including, but not limited to, fundamental aspects of animal nutrition such as nutritional requirements, metabolic studies, body composition, energetics, immunology, neuroscience, microbiology, genetics and molecular and cell biology related to primarily to the nutrition of farm animals and aquatic species. More applied aspects of animal nutrition, such as the evaluation of novel ingredients, feed additives and feed safety will also be considered but it is expected that such studies will have a strong nutritional focus. Animal Nutrition is indexed in SCIE, PubMed Central, Scopus, DOAJ, etc.
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