Yuying Wu , Bei Cheng , Longxiang Ji , Xiangyun Lv , Yingying Feng , Liu’an Li , Xin Wu
{"title":"日粮溶菌酶改善断奶仔猪生长性能和肠道屏障功能","authors":"Yuying Wu , Bei Cheng , Longxiang Ji , Xiangyun Lv , Yingying Feng , Liu’an Li , Xin Wu","doi":"10.1016/j.aninu.2023.06.003","DOIUrl":null,"url":null,"abstract":"<div><p>Lysozyme (LZ) is a purely natural, nonpolluting and nonspecific immune factor, which has beneficial effects on the healthy development of animals. In this study, the influences of LZ on the growth performance and intestinal barrier of weaned piglets were studied. A total of 48 weaned piglets (Landrace × Yorkshire, 22 d old) were randomly divided into a control group (basal diet) and a LZ group (0.1% LZ diet) for 19 d. The results showed that LZ could significantly improve the average daily gain (ADG, <em>P</em> < 0.05) and average daily feed intake (ADFI, <em>P</em> < 0.05). LZ also improved the intestinal morphology and significantly increased the expression of occludin in the jejunum (<em>P</em> < 0.05). In addition, LZ down-regulated the expression of interleukin-1β (<em>IL-1β</em>, <em>P</em> < 0.05) and tumor necrosis factor-α (<em>TNF-α</em>, <em>P</em> < 0.05), and inhibited the expression of the genes in the nuclear factor-k-gene binding (<em>NF-κB</em>, <em>P</em> < 0.05) signaling pathway. More importantly, the analysis of intestinal flora showed LZ increased the abundance of Firmicutes (<em>P</em> < 0.05) and the ratio of Firmicutes to Bacteroidota (<em>P</em> = 0.09) at the phylum level, and increased the abundance of <em>Clostridium_sensu_stricto_1</em> (<em>P</em> < 0.05) and reduced the abundance of <em>Olsenella</em> and <em>Prevotella</em> (<em>P</em> < 0.05) at the genus level. In short, this study proved that LZ could effectively improve the growth performance, relieve inflammation and improve the intestinal barrier function of weaned piglets. These findings provided an important theoretical basis for the application of LZ in pig production.</p></div>","PeriodicalId":62604,"journal":{"name":"Animal Nutrition","volume":null,"pages":null},"PeriodicalIF":6.3000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/76/76/main.PMC10472418.pdf","citationCount":"0","resultStr":"{\"title\":\"Dietary lysozyme improves growth performance and intestinal barrier function of weaned piglets\",\"authors\":\"Yuying Wu , Bei Cheng , Longxiang Ji , Xiangyun Lv , Yingying Feng , Liu’an Li , Xin Wu\",\"doi\":\"10.1016/j.aninu.2023.06.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Lysozyme (LZ) is a purely natural, nonpolluting and nonspecific immune factor, which has beneficial effects on the healthy development of animals. In this study, the influences of LZ on the growth performance and intestinal barrier of weaned piglets were studied. A total of 48 weaned piglets (Landrace × Yorkshire, 22 d old) were randomly divided into a control group (basal diet) and a LZ group (0.1% LZ diet) for 19 d. The results showed that LZ could significantly improve the average daily gain (ADG, <em>P</em> < 0.05) and average daily feed intake (ADFI, <em>P</em> < 0.05). LZ also improved the intestinal morphology and significantly increased the expression of occludin in the jejunum (<em>P</em> < 0.05). In addition, LZ down-regulated the expression of interleukin-1β (<em>IL-1β</em>, <em>P</em> < 0.05) and tumor necrosis factor-α (<em>TNF-α</em>, <em>P</em> < 0.05), and inhibited the expression of the genes in the nuclear factor-k-gene binding (<em>NF-κB</em>, <em>P</em> < 0.05) signaling pathway. More importantly, the analysis of intestinal flora showed LZ increased the abundance of Firmicutes (<em>P</em> < 0.05) and the ratio of Firmicutes to Bacteroidota (<em>P</em> = 0.09) at the phylum level, and increased the abundance of <em>Clostridium_sensu_stricto_1</em> (<em>P</em> < 0.05) and reduced the abundance of <em>Olsenella</em> and <em>Prevotella</em> (<em>P</em> < 0.05) at the genus level. In short, this study proved that LZ could effectively improve the growth performance, relieve inflammation and improve the intestinal barrier function of weaned piglets. These findings provided an important theoretical basis for the application of LZ in pig production.</p></div>\",\"PeriodicalId\":62604,\"journal\":{\"name\":\"Animal Nutrition\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":6.3000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/76/76/main.PMC10472418.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Animal Nutrition\",\"FirstCategoryId\":\"1091\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2405654523000744\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Animal Nutrition","FirstCategoryId":"1091","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405654523000744","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Dietary lysozyme improves growth performance and intestinal barrier function of weaned piglets
Lysozyme (LZ) is a purely natural, nonpolluting and nonspecific immune factor, which has beneficial effects on the healthy development of animals. In this study, the influences of LZ on the growth performance and intestinal barrier of weaned piglets were studied. A total of 48 weaned piglets (Landrace × Yorkshire, 22 d old) were randomly divided into a control group (basal diet) and a LZ group (0.1% LZ diet) for 19 d. The results showed that LZ could significantly improve the average daily gain (ADG, P < 0.05) and average daily feed intake (ADFI, P < 0.05). LZ also improved the intestinal morphology and significantly increased the expression of occludin in the jejunum (P < 0.05). In addition, LZ down-regulated the expression of interleukin-1β (IL-1β, P < 0.05) and tumor necrosis factor-α (TNF-α, P < 0.05), and inhibited the expression of the genes in the nuclear factor-k-gene binding (NF-κB, P < 0.05) signaling pathway. More importantly, the analysis of intestinal flora showed LZ increased the abundance of Firmicutes (P < 0.05) and the ratio of Firmicutes to Bacteroidota (P = 0.09) at the phylum level, and increased the abundance of Clostridium_sensu_stricto_1 (P < 0.05) and reduced the abundance of Olsenella and Prevotella (P < 0.05) at the genus level. In short, this study proved that LZ could effectively improve the growth performance, relieve inflammation and improve the intestinal barrier function of weaned piglets. These findings provided an important theoretical basis for the application of LZ in pig production.
期刊介绍:
Animal Nutrition encompasses the full gamut of animal nutritional sciences and reviews including, but not limited to, fundamental aspects of animal nutrition such as nutritional requirements, metabolic studies, body composition, energetics, immunology, neuroscience, microbiology, genetics and molecular and cell biology related to primarily to the nutrition of farm animals and aquatic species. More applied aspects of animal nutrition, such as the evaluation of novel ingredients, feed additives and feed safety will also be considered but it is expected that such studies will have a strong nutritional focus. Animal Nutrition is indexed in SCIE, PubMed Central, Scopus, DOAJ, etc.