肾脏时钟如何工作:基于人群数据组的eGFR昼夜节律模式。

IF 3.7 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
M C Lorenzo-Lozano, A L Blázquez-Manzanera, J A Carnicero
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引用次数: 0

摘要

肾功能的昼夜节律调节在过去几年中已被描述。在个人水平上也发现了肾小球滤过率(eGFR)的每日变化。本研究的目的是检查在人群数据组水平上是否存在eGFR的昼夜节律模式,并将群体结果与个体水平的结果进行比较。我们研究了2015年1月至2019年12月期间在西班牙两家医院急诊实验室分析的446,441份样本。我们使用CKD-EPI配方从18至85岁的患者中选择eGFR值在60至140 mL/min/1.73 m2之间的所有记录。在四个嵌套混合线性和正弦回归模型中,使用提取时间计算每日内在eGFR模式。所有模型均显示每日eGFR模式,但估计的模型系数因是否包括年龄而异。年龄的加入提高了模型的性能。在该模型中,高峰期发生在7:46 h。我们描述了两个不同种群中eGFR值随时间的分布。这种分布被调整为与个体节律相似的昼夜节律。这种模式在每家医院以及两家医院所研究的每一年都是相似的。研究结果表明,将“人口昼夜节律”的概念纳入科学领域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

How kidney clock works: circadian pattern of eGFR based on a population data group.

How kidney clock works: circadian pattern of eGFR based on a population data group.

A circadian regulation of renal function it has been described in the last few years. An intradaily variation in glomerular filtration rate (eGFR) has also been discovered at the individual level. The aim of this study was to check if there exists a circadian pattern of eGFR at population data group level and to compare the population results with those described at individual level. We have studied a total of 446,441 samples analysed in the emergency laboratories of two Spanish hospitals between January 2015 and December 2019. We selected all the records of eGFR values between 60 and 140 mL/min/1.73 m2 using CKD-EPI formula from patients between 18 and 85 years. The intradaily intrinsic eGFR pattern was computed using the extraction time of day in four nested mixed linear and sinusoidal regression models. All models showed an intradaily eGFR pattern, but the estimated model coefficients differed depending on whether age was included. The inclusion of age improved the performance of the model. In this model, the acrophase occurred at 7:46 h. We describe the distribution of eGFR values depending on the time in two different populations. This distribution is adjusted to a circadian rhythm that behaves similarly to the individual rhythm. This pattern is similar in each of the years studied from each hospital as well as between both hospitals. The results found suggest the incorporation of the concept of "population circadian rhythm" into the scientific world.

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来源期刊
Journal of physiology and biochemistry
Journal of physiology and biochemistry 生物-生化与分子生物学
CiteScore
6.60
自引率
0.00%
发文量
86
审稿时长
6-12 weeks
期刊介绍: The Journal of Physiology and Biochemistry publishes original research articles and reviews describing relevant new observations on molecular, biochemical and cellular mechanisms involved in human physiology. All areas of the physiology are covered. Special emphasis is placed on the integration of those levels in the whole-organism. The Journal of Physiology and Biochemistry also welcomes articles on molecular nutrition and metabolism studies, and works related to the genomic or proteomic bases of the physiological functions. Descriptive manuscripts about physiological/biochemical processes or clinical manuscripts will not be considered. The journal will not accept manuscripts testing effects of animal or plant extracts.
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