在抗癌领域，抓住隐性结合位点来中和耐药性

IF 6.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2023-09-01 DOI:10.1016/j.drudis.2023.103705

Wei-Cheng Yang , Dao-Hong Gong , Hong Wu , Yang-Yang Gao , Ge-Fei Hao

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引用次数: 0

摘要

耐药性是成功治疗癌症的一个重大障碍。利用和开发与癌症相关耐药(CRDR)有关的蛋白质中的隐结合位点(CBSs)有助于克服癌症相关耐药。然而，目前还没有对CBSs在解决CRDR方面的成功应用进行全面审查。在此，我们系统地总结和分析了利用CBSs解决CRDR的机遇和挑战，并揭示了CBSs在靶向CRDR中的关键作用。第一，我们确定了CRDR目标和相应的信用评级体系。其次，我们讨论了CBSs克服CRDR的机制。最后，我们提供了解决CRDR的成功CBS应用程序的示例。我们希望该方法能够为生物学家和化学家有效利用CBSs开发缓解CRDR的新药提供指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Grasping cryptic binding sites to neutralize drug resistance in the field of anticancer

Drug resistance is a significant obstacle to successful cancer treatment. The utilization and development of cryptic binding sites (CBSs) in proteins involved in cancer-related drug-resistance (CRDR) could help to overcome that drug resistance. However, there is no comprehensive review of the successful use of CBSs in addressing CRDR. Here, we have systematically summarized and analyzed the opportunities and challenges of using CBSs in addressing CRDR and revealed the key role that CBSs have in targeting CRDR. First, we have identified the CRDR targets and the corresponding CBSs. Second, we discuss the mechanisms by which CBSs can overcome CRDR. Finally, we have provided examples of successful CBS applications in addressing CRDR. We hope that this approach will provide guidance to biologists and chemists in effectively utilizing CBSs for the development of new drugs to alleviate CRDR.

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来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.