红海软珊瑚Dendronephthya spp中两个新的芳香a环甾体的细胞毒性和抗菌评价。

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-01-01 Epub Date: 2023-09-04 DOI:10.1080/14786419.2023.2254452

Ahmed H Eissa, Asmaa M Abdel-Tawab, Fawzia Z El-Ablack, Seif-Eldin N Ayyad

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引用次数: 0

摘要

对软珊瑚Dendronephthya spp.软珊瑚的CHCl3/MeOH粗提取物进行柱层析，分离出两种新的芳香A环甾体(1-2)和三种已知化合物(3-5)。1和2都是19-去甲类固醇。基于广泛的1D, 2D NMR和EIMS分析，化学结构得到了阐明。在细胞毒生物实验中，化合物1 ~ 5对MCF-7、NCI-1299和HepG2三种癌细胞的IC50分别为22.1 ~ 85.4 μM、26.9 ~ 88.7 μM和25.9 ~ 93.7 μM。化合物1、2和5在100和150µg/mL浓度下对大肠杆菌和假单胞菌有中等程度的抑制作用，在150µg/mL浓度下对蜡样芽孢杆菌和金黄色葡萄球菌有较弱的抑制作用。

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Cytotoxic and anti-bacterial evaluation of two new aromatic A-ring steroids isolated from the Red Sea soft coral Dendronephthya spp.

A successful column chromatography of a CHCl₃/MeOH crude extract of Dendronephthya spp. soft coral led to the isolation of two new aromatic A-ring steroids (1-2), together with three known compounds (3-5). Both 1 and 2 are 19-norsteroids. The chemical structures were elucidated based on extensive 1D, 2D NMR, and EIMS analyses. In cytotoxic bioassays, compounds 1-5 were tested against three cancer cell lines: MCF-7, NCI-1299, and HepG2, with IC₅₀ in the ranges of 22.1-85.4, 26.9-88.7, and 25.9-93.7 μM, respectively. Compounds 1, 2, and 5 showed moderate degrees of inhibition against Escherichia coli and Pseudomonas sp. at 100 and 150 µg/mL, while exhibiting weak inhibition against Bacillus cereus and Staphylococcus aureus at 150 µg/mL.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.