Phillip Weeks, Kelly Dunton, Brian Gulbis, Marwan Jumean, Lisa Janowiak, Igor Banjac, Rajko Radovancevic, Igor Gregoric, Biswajit Kar
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引用次数: 0
摘要
在开始静脉-动脉体外膜肺氧合(V-A ECMO)用于血流动力学支持后,患者通常需要血管升压和变力药物来支持他们的血压和心脏收缩力。血管活性变力性评分(VIS)是一种标准化的血管升压药和变力剂等效性计算,它使用每种药物的系数来计算总值。本研究评估了接受V-A ECMO支持的患者的30天生存率与VIS计算值之间的相关性 ECMO插管后h(VIS24)。这是一项单中心、回顾性、观察性队列研究。整个队列的VIS24中位数为6.0,并被确定为比较的截止值。VIS24患者 p = 0.03)。带有VIS24的组 11.4的患者生存率最低。这一发现可能有助于确定接受V-A ECMO血流动力学支持的患者中30天存活概率最低的患者。
Comparison of survival by vasoactive-inotropic score in patients receiving veno-arterial extracorporeal life support.
After the initiation of veno-arterial extracorporeal membrane oxygenation (V-A ECMO) for hemodynamic support, patients often require vasopressor and inotropic medications to support their blood pressure and cardiac contractility. The vasoactive-inotropic score (VIS) is a standardized calculation of vasopressor and inotrope equivalence, which uses coefficients for each medication to calculate a total value. This study evaluated the association between the 30-day survival of patients receiving V-A ECMO support and the VIS calculated 24 h after ECMO cannulation (VIS24). This was a single-center, retrospective, observational cohort study. The median VIS24 of the entire cohort was 6.0, and was determined as a cutoff for comparison. Patients with a VIS24 < 6.0 were assigned to a group, and those with a VIS24 ≥ 6.0 were assigned to a second group. Patients with a VIS24 < 6.0 had higher 30-day survival than those with a VIS24 ≥ 6.0 (54.5% vs 41.4%; p = 0.03). The group with a VIS24 < 6.0 also had significantly improved survival to decannulation of ECMO support; however, there was no difference in the survival to hospital discharge. We conducted a secondary analysis of quartiles and determined that individuals with a VIS24 > 11.4 had the lowest survival in the cohort. This finding may help identify patients with the lowest probability of 30-day survival in those receiving V-A ECMO for hemodynamic support.
期刊介绍:
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.