Phillip Weeks, Kelly Dunton, Brian Gulbis, Marwan Jumean, Lisa Janowiak, Igor Banjac, Rajko Radovancevic, Igor Gregoric, Biswajit Kar
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The median VIS24 of the entire cohort was 6.0, and was determined as a cutoff for comparison. Patients with a VIS24 < 6.0 were assigned to a group, and those with a VIS24 ≥ 6.0 were assigned to a second group. Patients with a VIS24 < 6.0 had higher 30-day survival than those with a VIS24 ≥ 6.0 (54.5% vs 41.4%; <i>p</i> = 0.03). The group with a VIS24 < 6.0 also had significantly improved survival to decannulation of ECMO support; however, there was no difference in the survival to hospital discharge. We conducted a secondary analysis of quartiles and determined that individuals with a VIS24 > 11.4 had the lowest survival in the cohort. 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引用次数: 0
摘要
在开始静脉-动脉体外膜肺氧合(V-A ECMO)用于血流动力学支持后,患者通常需要血管升压和变力药物来支持他们的血压和心脏收缩力。血管活性变力性评分(VIS)是一种标准化的血管升压药和变力剂等效性计算,它使用每种药物的系数来计算总值。本研究评估了接受V-A ECMO支持的患者的30天生存率与VIS计算值之间的相关性 ECMO插管后h(VIS24)。这是一项单中心、回顾性、观察性队列研究。整个队列的VIS24中位数为6.0,并被确定为比较的截止值。VIS24患者 p = 0.03)。带有VIS24的组 11.4的患者生存率最低。这一发现可能有助于确定接受V-A ECMO血流动力学支持的患者中30天存活概率最低的患者。
Comparison of survival by vasoactive-inotropic score in patients receiving veno-arterial extracorporeal life support.
After the initiation of veno-arterial extracorporeal membrane oxygenation (V-A ECMO) for hemodynamic support, patients often require vasopressor and inotropic medications to support their blood pressure and cardiac contractility. The vasoactive-inotropic score (VIS) is a standardized calculation of vasopressor and inotrope equivalence, which uses coefficients for each medication to calculate a total value. This study evaluated the association between the 30-day survival of patients receiving V-A ECMO support and the VIS calculated 24 h after ECMO cannulation (VIS24). This was a single-center, retrospective, observational cohort study. The median VIS24 of the entire cohort was 6.0, and was determined as a cutoff for comparison. Patients with a VIS24 < 6.0 were assigned to a group, and those with a VIS24 ≥ 6.0 were assigned to a second group. Patients with a VIS24 < 6.0 had higher 30-day survival than those with a VIS24 ≥ 6.0 (54.5% vs 41.4%; p = 0.03). The group with a VIS24 < 6.0 also had significantly improved survival to decannulation of ECMO support; however, there was no difference in the survival to hospital discharge. We conducted a secondary analysis of quartiles and determined that individuals with a VIS24 > 11.4 had the lowest survival in the cohort. This finding may help identify patients with the lowest probability of 30-day survival in those receiving V-A ECMO for hemodynamic support.
期刊介绍:
The International Journal of Artificial Organs (IJAO) publishes peer-reviewed research and clinical, experimental and theoretical, contributions to the field of artificial, bioartificial and tissue-engineered organs. The mission of the IJAO is to foster the development and optimization of artificial, bioartificial and tissue-engineered organs, for implantation or use in procedures, to treat functional deficits of all human tissues and organs.