γδT细胞与变态反应性疾病。

IF 8.4 2区 医学 Q1 ALLERGY
Clinical Reviews in Allergy & Immunology Pub Date : 2023-08-01 Epub Date: 2023-07-03 DOI:10.1007/s12016-023-08966-0
Uei-Hsiang Hsu, Bor-Luen Chiang
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引用次数: 0

摘要

γδT细胞在过敏性疾病中发挥着重要作用,近几十年来已成为潜在的治疗靶点。为了阐明γδT细胞在特应性疾病中的作用,我们回顾了关于γδT淋巴细胞各亚群的物理作用和功能的文献,包括1型辅助性T细胞(Th1)样、2型辅助性T细胞(Th2)样和17型辅助性特应性T细胞。小鼠Vγ1 T细胞增加白细胞介素(IL)-4水平并触发B细胞类别转换和免疫球蛋白E的产生。同时,小鼠Vγ4 T细胞和人CD8lowVδ1 T细胞分泌干扰素-γ,并发挥类似于Th1细胞的抗过敏作用。此外,小鼠Vγ6 T细胞产生IL-17A,而Th17样γδT细胞在炎症的急性期增强中性粒细胞和嗜酸性粒细胞的浸润,但在慢性期发挥抗炎作用。人Vγ9δ2 T细胞可能对某些类型的刺激表现出Th1或Th2样特征。此外,微生物群可以通过芳烃受体调节上皮γδT细胞的存活;这些γδT细胞在修复上皮损伤、抗菌保护、抗原耐受以及微生态失调对过敏性疾病的影响中发挥着至关重要的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

γδ T Cells and Allergic Diseases.

γδ T Cells and Allergic Diseases.

Gamma-delta (γδ) T cells play an essential role in allergic diseases and have emerged as a potential treatment target in recent decades. To clarify the effects of γδ T cells on atopic illnesses, we reviewed the literature on the physical roles and functions of various subsets of γδ T cells, including type 1 T helper (Th1)-like, type 2 T helper- (Th2)-like, and type 17 T helper (Th17)-like γδ T cells. Mouse Vγ1 T cells increase interleukin (IL)-4 levels and trigger B cell class switching and immunoglobulin E production. Meanwhile, mouse Vγ4 T cells and human CD8lowVδ1 T cells secrete interferon-γ and exert an anti-allergy effect similar to that of Th1 cells. Moreover, mouse Vγ6 T cells produce IL-17A, while Th17-like γδ T cells enhance neutrophil and eosinophil infiltration in the acute phase of inflammation, but exert anti-inflammatory effects in the chronic phase. Human Vγ9δ2 T cells may exhibit Th1- or Th2-like characteristics in response to certain types of stimulation. In addition, the microbiota can modulate epithelial γδ T cell survival through aryl hydrocarbon receptors; these γδ T cells play crucial roles in the repair of epithelial damage, antibacterial protection, antigen tolerance, and effects of dysbiosis on allergic diseases.

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来源期刊
CiteScore
22.30
自引率
1.10%
发文量
58
审稿时长
6-12 weeks
期刊介绍: Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.
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