Maria Vitoria Gomes da Silva, Laura Resende Guimarães Pereira, Lucimar Retto da Silva de Avó, Carla Maria Ramos Germano, Débora Gusmão Melo
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Further, it is associated with comorbidities, anatomical alterations of the respiratory tract, and immunological dysfunctions that make individuals more susceptible to respiratory infections.</p><p><strong>Objective: </strong>To systematize the current scientific knowledge about the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among individuals with DS.</p><p><strong>Design and setting: </strong>This integrative review was conducted at the Universidade Federal de São Carlos, São Paulo, Brazil.</p><p><strong>Methods: </strong>This review was conducted in the following databases: the Virtual Health Library (Biblioteca Virtual em Saúde, BVS), PubMed, and Web of Science, using MeSH descriptors. The search included English or Portuguese studies published between January 1, 2020, and October 14, 2022.</p><p><strong>Results: </strong>A total of 55 articles from 24 countries were selected, comprising 21 case-control or cohort studies, 23 case reports or series, and 11 narrative reviews or opinion studies. The articles were grouped into five categories: previous comorbidities, coronavirus disease 2019 (COVID-19) clinical features and evolution, cytokine storm and interleukins, living in institutions as a risk factor, and behavioral actions as a protective factor against SARS-CoV-2 infection.</p><p><strong>Conclusion: </strong>Individuals with DS are more susceptible to COVID-19 infection due to variables such as previous comorbidities, immunological factors, and their habitable environments. These aspects confer a higher risk of infection and an unfavorable clinical course. The precise pathways involved in the pathophysiology of COVID-19 in individuals with DS are not clear, thus requiring further studies.</p><p><strong>Systematic review registration: </strong>The Open Science Framework registered the research protocol (https://osf.io/jyb97/).</p>","PeriodicalId":49574,"journal":{"name":"Sao Paulo Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445757/pdf/","citationCount":"0","resultStr":"{\"title\":\"Enhancing understanding of SARS-CoV-2 infection among individuals with Down syndrome: An integrative review.\",\"authors\":\"Maria Vitoria Gomes da Silva, Laura Resende Guimarães Pereira, Lucimar Retto da Silva de Avó, Carla Maria Ramos Germano, Débora Gusmão Melo\",\"doi\":\"10.1590/1516-3180.2023.0015.R1.230523\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Down syndrome (DS) is a non-rare genetic condition that affects approximately 1 in every 800 live births worldwide. 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引用次数: 0
摘要
背景：唐氏综合症（DS）是一种非罕见的遗传病，在全球范围内，约每800名活产婴儿中就有1人受到影响。此外，它与合并症、呼吸道解剖结构改变和免疫功能障碍有关，这些因素使个体更容易受到呼吸道感染。目的：系统化DS患者中严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）感染的现有科学知识。设计和设置：这项综合综述在圣保罗圣卡洛斯联邦大学进行，方法：本综述在以下数据库中进行：虚拟健康图书馆（Biblioteca Virtual em Saúde，BVS）、PubMed和Web of Science，使用MeSH描述符。搜索包括2020年1月1日至2022年10月14日期间发表的英语或葡萄牙语研究。结果：共选择了来自24个国家的55篇文章，包括21项病例对照或队列研究、23份病例报告或系列以及11篇叙述性综述或观点研究。文章分为五类：既往合并症、2019冠状病毒病（新冠肺炎）临床特征和演变、细胞因子风暴和白细胞介素、作为风险因素生活在机构中以及作为预防SARS-CoV-2感染的保护因素的行为行为。结论：由于先前的合并症、免疫因素和居住环境等变量，DS患者更容易感染新冠肺炎。这些方面带来了更高的感染风险和不利的临床过程。DS患者新冠肺炎病理生理学中涉及的确切途径尚不清楚，因此需要进一步研究。系统评审注册：开放科学框架注册了研究方案(https://osf.io/jyb97/)。
Enhancing understanding of SARS-CoV-2 infection among individuals with Down syndrome: An integrative review.
Background: Down syndrome (DS) is a non-rare genetic condition that affects approximately 1 in every 800 live births worldwide. Further, it is associated with comorbidities, anatomical alterations of the respiratory tract, and immunological dysfunctions that make individuals more susceptible to respiratory infections.
Objective: To systematize the current scientific knowledge about the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among individuals with DS.
Design and setting: This integrative review was conducted at the Universidade Federal de São Carlos, São Paulo, Brazil.
Methods: This review was conducted in the following databases: the Virtual Health Library (Biblioteca Virtual em Saúde, BVS), PubMed, and Web of Science, using MeSH descriptors. The search included English or Portuguese studies published between January 1, 2020, and October 14, 2022.
Results: A total of 55 articles from 24 countries were selected, comprising 21 case-control or cohort studies, 23 case reports or series, and 11 narrative reviews or opinion studies. The articles were grouped into five categories: previous comorbidities, coronavirus disease 2019 (COVID-19) clinical features and evolution, cytokine storm and interleukins, living in institutions as a risk factor, and behavioral actions as a protective factor against SARS-CoV-2 infection.
Conclusion: Individuals with DS are more susceptible to COVID-19 infection due to variables such as previous comorbidities, immunological factors, and their habitable environments. These aspects confer a higher risk of infection and an unfavorable clinical course. The precise pathways involved in the pathophysiology of COVID-19 in individuals with DS are not clear, thus requiring further studies.
Systematic review registration: The Open Science Framework registered the research protocol (https://osf.io/jyb97/).
期刊介绍：
Published bimonthly by the Associação Paulista de Medicina, the journal accepts articles in the fields of clinical health science (internal medicine, gynecology and obstetrics, mental health, surgery, pediatrics and public health). Articles will be accepted in the form of original articles (clinical trials, cohort, case-control, prevalence, incidence, accuracy and cost-effectiveness studies and systematic reviews with or without meta-analysis), narrative reviews of the literature, case reports, short communications and letters to the editor. Papers with a commercial objective will not be accepted.
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