外科住院患者甲状腺功能减退治疗与死亡率的关系。

IF 1.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrine Research Pub Date : 2023-07-03 DOI:10.1080/07435800.2023.2220022

Hiba Masri-Iraqi, Yaron Rudman, Carmel Friedrich Dubinchik, Idit Dotan, Talia Diker-Cohen, Liat Sasson, Tzipora Shochat, Ilan Shimon, Eyal Robenshtok, Amit Akirov

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引用次数: 0

摘要

关于住院手术治疗甲状腺功能减退患者入院前促甲状腺激素(TSH)水平与预后之间关系的数据有限。我们回顾性评估了1451名接受左旋甲状腺素治疗的普通外科病房住院患者。TSH为5.0-10.0 mIU/L的患者30天死亡风险高出2倍(调整OR为2.3;95% CI 1.1-5.1)， TSH > 10.0 mIU/L的患者高出3倍(3.4;95% ci 1.3-8.7)。TSH 5.0-10.0及10.0 mIU/L以上患者的长期死亡风险较高(调整后HR为1.2;95% CI, 1.0-1.6和1.7;95% CI分别为1.2-2.4)。我们发现，在外科病房接受左旋甲状腺素治疗的成人中，入院前TSH水平升高与短期和长期死亡率升高相关。

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The Association Between Hypothyroidism Treatment and Mortality in Patients Hospitalized in Surgical Wards.

Limited data are available regarding the association between pre-admission thyroid-stimulating hormone (TSH) levels and prognosis in hospitalized surgical patients treated for hypothyroidism. We retrospectively evaluated a cohort of 1,451 levothyroxine-treated patients, hospitalized to general surgery wards. The 30-day mortality risk was 2-fold higher for patients with TSH of 5.0-10.0 mIU/L (adjusted OR, 2.3; 95% CI 1.1-5.1), and 3-fold higher for those with TSH > 10.0 mIU/L (3.4; 95% CI 1.3-8.7). Long-term mortality risk was higher in patients with TSH of 5.0-10.0 and above 10.0 mIU/L (adjusted HR, 1.2; 95% CI, 1.0-1.6, and 1.7; 95% CI 1.2-2.4, respectively). We found that in levothyroxine-treated adults hospitalized to surgical wards, increased pre-admission TSH levels are associated with increased short- and long-term mortality.

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来源期刊

Endocrine Research 医学-内分泌学与代谢

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： This journal publishes original articles relating to endocrinology in the broadest context. Subjects of interest include: receptors and mechanism of action of hormones, methodological advances in the detection and measurement of hormones; structure and chemical properties of hormones. Invitations to submit Brief Reviews are issued to specific authors by the Editors.