Yao Liu, Xiaochuan Gao, Lingmei Yuan, Yanming Li, Peiwei Hong
{"title":"甘油三酯葡萄糖指数与偏头痛的关系:来自国家健康与营养调查(NHANES)的横断面研究。","authors":"Yao Liu, Xiaochuan Gao, Lingmei Yuan, Yanming Li, Peiwei Hong","doi":"10.2174/1567202620666230606100652","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Insulin resistance is a phenomenon in which the lowering blood glucose capacity of insulin is decreased, which is a feature of type 2 diabetes mellitus. Some previous studies have found an association between insulin resistance and migraine. The triglyceride glucose (TyG) index is used to assess insulin resistance. However, there is no report on the association between the TyG index and migraine.</p><p><strong>Objective: </strong>We present a cross-sectional study from the National Health and Nutrition Examination Survey (NHANES) to clarify the association between the TyG index and migraine.</p><p><strong>Methods: </strong>Data was acquired from the NHANES. Migraine was diagnosed based on patient selfreport and prescription medication. Data were analyzed using the weighted linear regression model, weighted chi-square test, logistic regression models, smooth curve fittings, and the twopiecewise linear regression model. Empower software was used for all data analysis.</p><p><strong>Results: </strong>A total of 18704 participants were enrolled in this study, of which 209 were migraineurs. The rest were set as control. There was a statistically significant difference in mean age (p = 0.0222), gender (p < 0.0001), distribution of race (P < 0.0001), and drug usage between the two groups. However, there were no differences in type 2 diabetes mellitus, type 1 diabetes mellitus, total cholesterol, triglycerides, glucose, and TyG index between the two groups. According to logistic regression models, there was a linear relationship between TyG index and migraine in model 3 (odds ratio (OR = 0.54, p = 0.0165). particularly in female (OR= 0.51, p = 0.0202) or Mexican American (OR= 0.18, p = 0.0203). Moreover, there was no inflection point between the TyG index and migraine.</p><p><strong>Conclusion: </strong>In conclusion, there was a linear relationship between the TyG index and migraine. A higher TyG index predicts a lower incidence of migraine, particularly in females and Mexican Americans. Meanwhile, there is no inflection point between the TyG index and migraine.</p>","PeriodicalId":10879,"journal":{"name":"Current neurovascular research","volume":"20 2","pages":"230-236"},"PeriodicalIF":2.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Relationship between Triglyceride Glucose Index and Migraine: A Cross-Section Study from the National Health and Nutrition Examination Survey (NHANES).\",\"authors\":\"Yao Liu, Xiaochuan Gao, Lingmei Yuan, Yanming Li, Peiwei Hong\",\"doi\":\"10.2174/1567202620666230606100652\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Insulin resistance is a phenomenon in which the lowering blood glucose capacity of insulin is decreased, which is a feature of type 2 diabetes mellitus. Some previous studies have found an association between insulin resistance and migraine. The triglyceride glucose (TyG) index is used to assess insulin resistance. However, there is no report on the association between the TyG index and migraine.</p><p><strong>Objective: </strong>We present a cross-sectional study from the National Health and Nutrition Examination Survey (NHANES) to clarify the association between the TyG index and migraine.</p><p><strong>Methods: </strong>Data was acquired from the NHANES. Migraine was diagnosed based on patient selfreport and prescription medication. Data were analyzed using the weighted linear regression model, weighted chi-square test, logistic regression models, smooth curve fittings, and the twopiecewise linear regression model. Empower software was used for all data analysis.</p><p><strong>Results: </strong>A total of 18704 participants were enrolled in this study, of which 209 were migraineurs. The rest were set as control. There was a statistically significant difference in mean age (p = 0.0222), gender (p < 0.0001), distribution of race (P < 0.0001), and drug usage between the two groups. However, there were no differences in type 2 diabetes mellitus, type 1 diabetes mellitus, total cholesterol, triglycerides, glucose, and TyG index between the two groups. According to logistic regression models, there was a linear relationship between TyG index and migraine in model 3 (odds ratio (OR = 0.54, p = 0.0165). particularly in female (OR= 0.51, p = 0.0202) or Mexican American (OR= 0.18, p = 0.0203). Moreover, there was no inflection point between the TyG index and migraine.</p><p><strong>Conclusion: </strong>In conclusion, there was a linear relationship between the TyG index and migraine. A higher TyG index predicts a lower incidence of migraine, particularly in females and Mexican Americans. Meanwhile, there is no inflection point between the TyG index and migraine.</p>\",\"PeriodicalId\":10879,\"journal\":{\"name\":\"Current neurovascular research\",\"volume\":\"20 2\",\"pages\":\"230-236\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current neurovascular research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2174/1567202620666230606100652\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current neurovascular research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/1567202620666230606100652","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景:胰岛素抵抗是胰岛素降血糖能力下降的一种现象，是2型糖尿病的一个特征。之前的一些研究已经发现了胰岛素抵抗和偏头痛之间的联系。甘油三酯葡萄糖(TyG)指数用于评估胰岛素抵抗。然而，没有关于TyG指数和偏头痛之间关系的报道。目的:我们提出了一项来自国家健康和营养调查(NHANES)的横断面研究，以阐明TyG指数与偏头痛之间的关系。方法:数据来源于NHANES。偏头痛的诊断是基于患者的自我报告和处方药物。数据分析采用加权线性回归模型、加权卡方检验、logistic回归模型、平滑曲线拟合和双片线性回归模型。所有数据分析均使用Empower软件。结果:共有18704名参与者参加了这项研究，其中209名是偏头痛患者。其余的作为对照。两组患者的平均年龄(p = 0.0222)、性别(p < 0.0001)、种族分布(p < 0.0001)、用药情况等差异均有统计学意义。2型糖尿病、1型糖尿病、总胆固醇、甘油三酯、葡萄糖、TyG指数两组无差异。根据logistic回归模型，模型3中TyG指数与偏头痛存在线性关系(优势比(OR = 0.54, p = 0.0165)。尤其是女性(OR= 0.51, p = 0.0202)或墨西哥裔美国人(OR= 0.18, p = 0.0203)。此外，TyG指数与偏头痛之间没有拐点。结论:TyG指数与偏头痛有一定的线性关系。TyG指数越高，偏头痛的发病率就越低，尤其是女性和墨西哥裔美国人。同时，TyG指数与偏头痛之间不存在拐点。
The Relationship between Triglyceride Glucose Index and Migraine: A Cross-Section Study from the National Health and Nutrition Examination Survey (NHANES).
Background: Insulin resistance is a phenomenon in which the lowering blood glucose capacity of insulin is decreased, which is a feature of type 2 diabetes mellitus. Some previous studies have found an association between insulin resistance and migraine. The triglyceride glucose (TyG) index is used to assess insulin resistance. However, there is no report on the association between the TyG index and migraine.
Objective: We present a cross-sectional study from the National Health and Nutrition Examination Survey (NHANES) to clarify the association between the TyG index and migraine.
Methods: Data was acquired from the NHANES. Migraine was diagnosed based on patient selfreport and prescription medication. Data were analyzed using the weighted linear regression model, weighted chi-square test, logistic regression models, smooth curve fittings, and the twopiecewise linear regression model. Empower software was used for all data analysis.
Results: A total of 18704 participants were enrolled in this study, of which 209 were migraineurs. The rest were set as control. There was a statistically significant difference in mean age (p = 0.0222), gender (p < 0.0001), distribution of race (P < 0.0001), and drug usage between the two groups. However, there were no differences in type 2 diabetes mellitus, type 1 diabetes mellitus, total cholesterol, triglycerides, glucose, and TyG index between the two groups. According to logistic regression models, there was a linear relationship between TyG index and migraine in model 3 (odds ratio (OR = 0.54, p = 0.0165). particularly in female (OR= 0.51, p = 0.0202) or Mexican American (OR= 0.18, p = 0.0203). Moreover, there was no inflection point between the TyG index and migraine.
Conclusion: In conclusion, there was a linear relationship between the TyG index and migraine. A higher TyG index predicts a lower incidence of migraine, particularly in females and Mexican Americans. Meanwhile, there is no inflection point between the TyG index and migraine.
期刊介绍：
Current Neurovascular Research provides a cross platform for the publication of scientifically rigorous research that addresses disease mechanisms of both neuronal and vascular origins in neuroscience. The journal serves as an international forum publishing novel and original work as well as timely neuroscience research articles, full-length/mini reviews in the disciplines of cell developmental disorders, plasticity, and degeneration that bridges the gap between basic science research and clinical discovery. Current Neurovascular Research emphasizes the elucidation of disease mechanisms, both cellular and molecular, which can impact the development of unique therapeutic strategies for neuronal and vascular disorders.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
