溃疡性结肠炎伴肺部受累的嗜酸性粒细胞增多综合征。

Anam Bashir, Jose M Cabrera, Mariko Suchi, Barry J Pelz
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引用次数: 0

摘要

反应性嗜酸性粒细胞增多与炎症性肠病有关,与克罗恩病相比,在溃疡性结肠炎(UC)患者中更为常见。在一项儿科研究中,炎症性肠病患者外周血嗜酸性粒细胞增多的患病率高达30%-40%。高嗜酸性粒细胞综合征(HES)和UC共存是罕见的。我们报告了一名15岁的男孩,他患有UC合并HES,表现为胸痛和呼吸急促。实验室检查显示明显的嗜酸性粒细胞增多。其他嗜酸性粒细胞增多的原因包括嗜酸性粒细胞白血病、感染或药物性嗜酸性粒细胞肺炎被排除。患者最终被诊断为对mepolizumab有反应的HES。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Hypereosinophilic Syndrome with Pulmonary Involvement in Ulcerative Colitis.

Hypereosinophilic Syndrome with Pulmonary Involvement in Ulcerative Colitis.

Hypereosinophilic Syndrome with Pulmonary Involvement in Ulcerative Colitis.

Hypereosinophilic Syndrome with Pulmonary Involvement in Ulcerative Colitis.

Reactive eosinophilia is associated with inflammatory bowel disease and is more common in patients with ulcerative colitis (UC) compared with Crohn's disease. The prevalence rate of peripheral blood eosinophilia in patients with inflammatory bowel disease has been described to be as high as 30%-40% of patients in a pediatric study. The coexistence of hypereosinophilic syndrome (HES) and UC is uncommon. We present a 15-year-old boy with UC associated with HES who presented with chest pain and shortness of breath. Laboratory evaluation showed marked eosinophilia. Alternative causes of eosinophilia including eosinophilic leukemia, infections, or drug-induced eosinophilic pneumonia were ruled out. The patient was ultimately diagnosed with HES responsive to mepolizumab.

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