CACNA1C基因rs216009单核苷酸多态性与体模牙痛有关。

IF 2.8 3区 医学 Q2 NEUROSCIENCES
Masako Morii, Seii Ohka, Daisuke Nishizawa, Junko Hasegawa, Kyoko Nakayama, Yuko Ebata, Moe Soeda, Ken-Ichi Fukuda, Kaori Yoshida, Kyotaro Koshika, Tatsuya Ichinohe, Kazutaka Ikeda
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引用次数: 0

摘要

假牙痛(PTP)是一种罕见且特殊的神经性疼痛,发生在牙髓切除术和拔牙后,但其原因尚不清楚。我们假设PTP存在遗传因素。本研究的重点是CACNA1C基因,该基因编码Cav1.2 L-型Ca2+通道(LTCC)的α1C亚基,在先前的研究中已报道该亚基与神经性疼痛有关。我们研究了导致PTP的遗传多态性。我们对33名PTP患者和118名无PTP但口腔面部疼痛或感觉障碍的患者的遗传多态性与PTP易感性之间的相关性进行了统计研究。从CACNA1C基因内部和周围,选择了155个多态性,并对其与临床数据的相关性进行了分析。我们发现隐性模型中CACNA1C基因的rs216009单核苷酸多态性(SNP)与PTP的易感性显著相关。rs216009小C等位基因的同卵携带者PTP发生率较高。据报道,神经性疼痛中的伤害感受传递涉及LTCCs的Ca2+内流,rs216009多态性可能参与CACNA1C的表达,CACNA1C调节细胞内Ca2+水平,导致对PTP的易感性。此外,心理因素可能通过调节下行疼痛抑制系统而导致PTP的发展。总之,rs216009 SNP的纯合C等位基因携带者更容易受到PTP的影响,可能是通过调节细胞内Ca2+水平和情感疼痛系统,例如那些介导恐惧记忆回忆的系统。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The rs216009 single-nucleotide polymorphism of the <i>CACNA1C</i> gene is associated with phantom tooth pain.

The rs216009 single-nucleotide polymorphism of the <i>CACNA1C</i> gene is associated with phantom tooth pain.

The rs216009 single-nucleotide polymorphism of the CACNA1C gene is associated with phantom tooth pain.

Phantom tooth pain (PTP) is a rare and specific neuropathic pain that occurs after pulpectomy and tooth extraction, but its cause is not understood. We hypothesized that there is a genetic contribution to PTP. The present study focused on the CACNA1C gene, which encodes the α1C subunit of the Cav1.2 L-type Ca2+ channel (LTCC) that has been reported to be associated with neuropathic pain in previous studies. We investigated genetic polymorphisms that contribute to PTP. We statistically examined the association between genetic polymorphisms and PTP vulnerability in 33 patients with PTP and 118 patients without PTP but with pain or dysesthesia in the orofacial region. From within and around the CACNA1C gene, 155 polymorphisms were selected and analyzed for associations with clinical data. We found that the rs216009 single-nucleotide polymorphism (SNP) of the CACNA1C gene in the recessive model was significantly associated with the vulnerability to PTP. Homozygote carriers of the minor C allele of rs216009 had a higher rate of PTP. Nociceptive transmission in neuropathic pain has been reported to involve Ca2+ influx from LTCCs, and the rs216009 polymorphism may be involved in CACNA1C expression, which regulates intracellular Ca2+ levels, leading to the vulnerability to PTP. Furthermore, psychological factors may lead to the development of PTP by modulating the descending pain inhibitory system. Altogether, homozygous C-allele carriers of the rs216009 SNP were more likely to be vulnerable to PTP, possibly through the regulation of intracellular Ca2+ levels and affective pain systems, such as those that mediate fear memory recall.

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来源期刊
Molecular Pain
Molecular Pain 医学-神经科学
CiteScore
5.60
自引率
3.00%
发文量
56
审稿时长
6-12 weeks
期刊介绍: Molecular Pain is a peer-reviewed, open access journal that considers manuscripts in pain research at the cellular, subcellular and molecular levels. Molecular Pain provides a forum for molecular pain scientists to communicate their research findings in a targeted manner to others in this important and growing field.
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