从 Cichorium intybus 的根中提取出一种具有降血糖活性的新 12，8-guaianolide 倍半萜内酯。

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-09-16 DOI:10.1080/14786419.2023.2230606

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引用次数: 0

摘要

从 Cichorium intybus L 的根中分离出了三种 12，8-guaianolide 倍半萜内酯，包括一种新化合物 intybusin F（1）和一种新天然产物 cichoriolide I（2），以及六种已知的 12，6-guaianolide 化合物（4-9）。根据对实验和计算电子圆二色光谱的分析，阐明了新化合物的绝对构型。化合物 1、2、4、7、8 在 50 μM 的浓度下对油酸加高葡萄糖刺激的 HepG2 细胞的葡萄糖摄取有显著的促进作用。此外，化合物 1、2、3、6、7 对 NO 的产生有明显的抑制作用，其中化合物 1、2、7 能显著降低高血糖 HepG2 细胞模型中炎性细胞因子（TNF-α、IL-6 和 COX-2）的分泌水平。

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One new 12, 8-guaianolide sesquiterpene lactone with antihyperglycemic activity from the roots of Cichorium intybus

Three 12, 8-guaianolide sesquiterpene lactones, including a new compound intybusin F (1), and a new natural product cichoriolide I (2), along with six known 12, 6-guaianolide compounds (4–9) were isolated from the roots of Cichorium intybus L. Their structures were determined by extensive spectroscopic analysis. The absolute configurations of new compounds were elucidated based on analysis of the experimental and calculated electronic circular dichroism spectra. Compounds 1, 2, 4, 7, 8 showed significant effects on facilitating the glucose uptake in oleic acid plus high glucose-stimulated HepG2 cells at 50 μM. In addition, compounds 1, 2, 3, 6, 7 exhibited obvious inhibitory effects against NO production, of them, compounds 1, 2, 7 can significantly decrease the secretion of inflammatory cytokines (TNF-α, IL-6 and COX-2) levels in this hyperglycemic HepG2 cell model.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.