血液透析受者肌肉减少症表达的性别差异:来自健康队列的分析。

IF 1.7 Q3 UROLOGY & NEPHROLOGY
Benjamin M Anderson, Daisy V Wilson, Muhammad Qasim, Gonzalo Correa, Felicity Evison, Suzy Gallier, Charles J Ferro, Thomas A Jackson, Adnan Sharif
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引用次数: 0

摘要

背景:关于血液透析中肌肉减少症和虚弱之间的相互作用的研究很少,特别是关于性别差异的研究。我们的目的是(1)评估超声来源的低肌肉量(LMM)和肌肉减少症是否在男性或女性血液透析受者中更常见;(2)评估年龄是否影响任何观察到的性别差异;(3)探讨血液透析受者肌肉减少症、虚弱和性别之间的相互作用。方法:这是一项对具有脆弱表型(FP)评分的成人流行(≥3个月)血液透析亚组的探索性分析。根据既定的超声方案获得双侧大腿前厚度(BATT)。通过线性和逻辑回归对BATT、LMM和肌肉减少症的相关性进行了探讨,并按性别进行了先验协变量分层。结果:共有223项研究,参与者进行了超声测量。男性LMM患病率较高。经校正分析,LMM与男性握力较低相关(β = -4.17;95% ci -7.57 -0.77;P=0.02),但雌性没有(β = -1.88;95% C.I. -5.41至1.64;P = 0.29)。LMM还与两名男性的步行速度较慢有关(β = -0.115;95% C.I. -0.258 ~ -0.013;P=0.03)和女性(β = -0.152;95% C.I. -0.300 ~ -0.005;P = 0.04)。在调整后的模型中,男性肌肉减少症与更大的虚弱几率相关(OR = 9.86;95% C.I. 1.8至54.0;P=0.01),女性无差异(OR = 5.16;95% C.I. 0.22 ~ 124;P = 0.31)。结论:血液透析患者骨骼肌减少症的临床表现及意义在男性和女性之间存在显著差异。需要进一步的工作来阐明潜在的机制并指导量身定制的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Gender Disparity in Expression of Sarcopenia in Haemodialysis Recipients: Analysis from the FITNESS Cohort.

Gender Disparity in Expression of Sarcopenia in Haemodialysis Recipients: Analysis from the FITNESS Cohort.

Gender Disparity in Expression of Sarcopenia in Haemodialysis Recipients: Analysis from the FITNESS Cohort.

Gender Disparity in Expression of Sarcopenia in Haemodialysis Recipients: Analysis from the FITNESS Cohort.

Background: There has been little exploration of the interplay between sarcopenia and frailty in haemodialysis, particularly regarding gender difference. We aimed to (1) assess whether ultrasound-derived low muscle mass (LMM) and sarcopenia are more common in male or female haemodialysis recipients; (2) assess whether age influences any observed gender difference, and (3) explore the interplay between sarcopenia, frailty, and gender in haemodialysis recipients.

Methods: This was an exploratory analysis of a subgroup of adult prevalent (≥3 months) haemodialysis with frailty phenotype (FP) scores. Bilateral anterior thigh thickness (BATT) was obtained according to an established ultrasound protocol. Associations with frailty were explored via both linear and logistic regressions for BATT, LMM, and sarcopenia with a priori covariables, stratified by gender.

Results: In total of 223 studies, participants had ultrasound measurements. Males showed greater prevalence of LMM. On adjusted analyses, LMM was associated with lower hand grip strength in males (β = -4.17; 95% C.I. -7.57 to -0.77; P=0.02), but not females (β = -1.88; 95% C.I. -5.41 to 1.64; P=0.29). LMM was also associated with slower walking speed in both males (β = -0.115; 95% C.I. -0.258 to -0.013; P=0.03) and females (β = -0.152; 95% C.I. -0.300 to -0.005; P=0.04). Sarcopenia was associated with greater odds of frailty on adjusted models in males (OR = 9.86; 95% C.I. 1.8 to 54.0; P=0.01), but not females (OR = 5.16; 95% C.I. 0.22 to 124; P=0.31).

Conclusions: The clinical expression and significance of sarcopenia differ substantially between males and females on haemodialysis. Further work is required to elucidate underlying mechanisms and guide tailored treatment.

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来源期刊
International Journal of Nephrology
International Journal of Nephrology UROLOGY & NEPHROLOGY-
CiteScore
3.40
自引率
4.80%
发文量
44
审稿时长
17 weeks
期刊介绍: International Journal of Nephrology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies focusing on the prevention, diagnosis, and management of kidney diseases and associated disorders. The journal welcomes submissions related to cell biology, developmental biology, genetics, immunology, pathology, pathophysiology of renal disease and progression, clinical nephrology, dialysis, and transplantation.
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