{"title":"通过阿育吠陀对Vandhyatva w.s.r.治疗子宫内膜变薄——一项单臂开放标记的试点临床试验。","authors":"Jalpa Deepak Rupareliya, Shilpa Donga, Abhay Jayprakash Gandhi","doi":"10.4103/ayu.ayu_132_21","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The four essential factors of conception are <i>Ritu</i> (optimum period for conception), <i>Kshetra</i> (place of conception), <i>Ambu</i> (nutrition), and <i>Beeja</i> (healthy sperm and ovum). <i>Kshetra</i> denotes body as general and to be very specific, especially about the female reproductive system, it is <i>Garbhashaya</i> or the uterine cavity and function is <i>Garbhadhana</i> or conception. The endometrial factor is an important subset in infertility due to poor implantation.</p><p><strong>Aims: </strong>To evaluate the efficacy of <i>Saubhagyanandana Ghrita Yonipichu</i> (vaginal tampoon) and <i>Jeevaniya Churna</i> orally in the management of thin endometrium thickness and to evaluate its efficacy in the associate complains of menstrual abnormalities, i.e., irregularity of menstrual cycle, quantity, duration and pain.</p><p><strong>Materials and methods: </strong>It was a single-arm open labeled pilot clinical trial, a total of 15 female patients having endometrial thickness <7 mm on transvaginal sonography findings were included in the study. Each patient (<i>n</i> = 15) was given <i>Saubhagyanandana Ghrita Yonipichu</i> (10 mL for 6 days after cessation of menses, for 1 cycle) along with <i>Jeevaniya Churna</i> orally 10 g along with milk twice before meals for 30 days. Assessment of the study was done on Appelbaum's uterine scoring system for the reproduction (USSR) scoring pattern.</p><p><strong>Results: </strong>Results were analyzed by the paired' <i>t</i>-test for the objective parameters and Wilcoxon signed rank-sum test for the subjective parameters. A statistically highly significant difference (<i>P</i> < 0.001) was seen in endometrium thickness, layering, myometrial echogenicity, uterine Doppler flow, endometrial blood flow in zone 3, and total USSR score. Statistical significant difference (<i>P</i> < 0.05) was found in the menstrual abnormalities and a highly statistically significant difference (<i>P</i> < 0.001) was found in ovulation. One of the patients conceived after the treatment.</p><p><strong>Conclusion: </strong><i>Saubhagyanandana Ghrita Yonipichu</i> (vaginal tampoon) and <i>Jeevaniya Churna</i> orally are effective in improving the thin endometrium.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/90/78/AYU-42-156.PMC10281244.pdf","citationCount":"0","resultStr":"{\"title\":\"Management of <i>Vandhyatva</i> w.s.r. to thin endometrium through <i>Ayurveda</i>- A single arm open labelled pilot clinical trial.\",\"authors\":\"Jalpa Deepak Rupareliya, Shilpa Donga, Abhay Jayprakash Gandhi\",\"doi\":\"10.4103/ayu.ayu_132_21\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The four essential factors of conception are <i>Ritu</i> (optimum period for conception), <i>Kshetra</i> (place of conception), <i>Ambu</i> (nutrition), and <i>Beeja</i> (healthy sperm and ovum). <i>Kshetra</i> denotes body as general and to be very specific, especially about the female reproductive system, it is <i>Garbhashaya</i> or the uterine cavity and function is <i>Garbhadhana</i> or conception. The endometrial factor is an important subset in infertility due to poor implantation.</p><p><strong>Aims: </strong>To evaluate the efficacy of <i>Saubhagyanandana Ghrita Yonipichu</i> (vaginal tampoon) and <i>Jeevaniya Churna</i> orally in the management of thin endometrium thickness and to evaluate its efficacy in the associate complains of menstrual abnormalities, i.e., irregularity of menstrual cycle, quantity, duration and pain.</p><p><strong>Materials and methods: </strong>It was a single-arm open labeled pilot clinical trial, a total of 15 female patients having endometrial thickness <7 mm on transvaginal sonography findings were included in the study. Each patient (<i>n</i> = 15) was given <i>Saubhagyanandana Ghrita Yonipichu</i> (10 mL for 6 days after cessation of menses, for 1 cycle) along with <i>Jeevaniya Churna</i> orally 10 g along with milk twice before meals for 30 days. Assessment of the study was done on Appelbaum's uterine scoring system for the reproduction (USSR) scoring pattern.</p><p><strong>Results: </strong>Results were analyzed by the paired' <i>t</i>-test for the objective parameters and Wilcoxon signed rank-sum test for the subjective parameters. A statistically highly significant difference (<i>P</i> < 0.001) was seen in endometrium thickness, layering, myometrial echogenicity, uterine Doppler flow, endometrial blood flow in zone 3, and total USSR score. Statistical significant difference (<i>P</i> < 0.05) was found in the menstrual abnormalities and a highly statistically significant difference (<i>P</i> < 0.001) was found in ovulation. One of the patients conceived after the treatment.</p><p><strong>Conclusion: </strong><i>Saubhagyanandana Ghrita Yonipichu</i> (vaginal tampoon) and <i>Jeevaniya Churna</i> orally are effective in improving the thin endometrium.</p>\",\"PeriodicalId\":8720,\"journal\":{\"name\":\"Ayu\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/90/78/AYU-42-156.PMC10281244.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ayu\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/ayu.ayu_132_21\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/5/17 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ayu","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ayu.ayu_132_21","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/5/17 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Management of Vandhyatva w.s.r. to thin endometrium through Ayurveda- A single arm open labelled pilot clinical trial.
Background: The four essential factors of conception are Ritu (optimum period for conception), Kshetra (place of conception), Ambu (nutrition), and Beeja (healthy sperm and ovum). Kshetra denotes body as general and to be very specific, especially about the female reproductive system, it is Garbhashaya or the uterine cavity and function is Garbhadhana or conception. The endometrial factor is an important subset in infertility due to poor implantation.
Aims: To evaluate the efficacy of Saubhagyanandana Ghrita Yonipichu (vaginal tampoon) and Jeevaniya Churna orally in the management of thin endometrium thickness and to evaluate its efficacy in the associate complains of menstrual abnormalities, i.e., irregularity of menstrual cycle, quantity, duration and pain.
Materials and methods: It was a single-arm open labeled pilot clinical trial, a total of 15 female patients having endometrial thickness <7 mm on transvaginal sonography findings were included in the study. Each patient (n = 15) was given Saubhagyanandana Ghrita Yonipichu (10 mL for 6 days after cessation of menses, for 1 cycle) along with Jeevaniya Churna orally 10 g along with milk twice before meals for 30 days. Assessment of the study was done on Appelbaum's uterine scoring system for the reproduction (USSR) scoring pattern.
Results: Results were analyzed by the paired' t-test for the objective parameters and Wilcoxon signed rank-sum test for the subjective parameters. A statistically highly significant difference (P < 0.001) was seen in endometrium thickness, layering, myometrial echogenicity, uterine Doppler flow, endometrial blood flow in zone 3, and total USSR score. Statistical significant difference (P < 0.05) was found in the menstrual abnormalities and a highly statistically significant difference (P < 0.001) was found in ovulation. One of the patients conceived after the treatment.
Conclusion: Saubhagyanandana Ghrita Yonipichu (vaginal tampoon) and Jeevaniya Churna orally are effective in improving the thin endometrium.
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