FMR1 CGG重复和压力影响母亲自我报告的认知功能。

IF 1.9 4区医学 Q1 EDUCATION, SPECIAL

Ajidd-American Journal on Intellectual and Developmental Disabilities Pub Date : 2023-01-01 DOI:10.1352/1944-7558-128.1.1

Nell Maltman, Leann Smith DaWalt, Jinkuk Hong, Mei Wang Baker, Elizabeth M Berry-Kravis, Murray H Brilliant, Marsha Mailick

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引用次数: 4

摘要

FMR1基因的变异可能影响认知的各个方面，如执行功能和记忆。环境因素，如压力，也可能对认知功能产生负面影响。参与者包括1053名有或没有发育障碍儿童的母亲。参与者完成了执行功能、记忆和压力(即生活事件、养育状况)的自我报告测量，并提供DNA来确定CGG重复长度(范围从7到192个CGG)。压力暴露显著预示着更大的自我报告的执行功能困难和记忆问题的可能性。立方CGG效应独立预测执行功能和记忆困难，表明遗传变异和环境应激暴露对认知功能都有影响。

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FMR1 CGG Repeats and Stress Influence Self-Reported Cognitive Functioning in Mothers.

Variation in the FMR1 gene may affect aspects of cognition, such as executive function and memory. Environmental factors, such as stress, may also negatively impact cognitive functioning. Participants included 1,053 mothers of children with and without developmental disabilities. Participants completed self-report measures of executive function, memory, and stress (i.e., life events, parenting status), and provided DNA to determine CGG repeat length (ranging from 7 to 192 CGGs). Stress exposure significantly predicted greater self-reported difficulties in executive function and the likelihood of memory problems. Cubic CGG effects independently predicted executive function and memory difficulties, suggesting effects of both genetic variation and environmental stress exposure on cognitive functioning.

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来源期刊

Ajidd-American Journal on Intellectual and Developmental Disabilities Multiple-

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： The American Journal on Intellectual and Developmental Disabilities (Print ISSN: 1944–7515; Online ISSN: 1944–7558) is published by the American Association on Intellectual and Developmental Disabilities. It is a scientifi c, scholarly, and archival multidisciplinary journal for reporting original contributions of the highest quality to knowledge of intellectual disabilities, its causes, treatment, and prevention.