Jonathan Wadsley, Alan Christie, Roopinder Gillmore, Amy Trinh, Rachel Greig
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引用次数: 0
摘要
晚期胆管癌（CCA）的治疗具有挑战性。对于晚期CCA患者，吉西他滨/顺铂联合化疗是标准的一线化疗方案，随后保留以5-氟尿嘧啶为基础的方案；然而，预期生存率较低。佩吉加替尼被批准用于治疗 FGFR2 融合或重排的局部晚期或转移性 CCA。佩吉加替尼具有可控的安全性，并可获得持久的应答。在英国，已有近 50 名 CCA 患者接受了培美加替尼的治疗。然而，目前尚缺乏使用培美加替尼的临床经验。我们介绍了三个临床病例的经验，以说明培美加替尼在治疗CCA及相关毒性反应中的地位。
Clinical experience with pemigatinib for previously treated metastatic cholangiocarcinoma: practical considerations from clinical cases.
The management of advanced cholangiocarcinoma (CCA) is challenging. In patients with advanced CCA, gemcitabine/cisplatin combination is the standard frontline chemotherapy, with 5-fluorouracil-based regimens preserved for subsequent lines; however, the expected survival is poor. Pemigatinib was approved for locally advanced or metastatic CCA with FGFR2 fusions or rearrangement. Pemigatinib has a manageable safety profile and achieves a durable response. Nearly 50 patients with CCA have been treated with pemigatinib in the United Kingdom. However, clinical experience with pemigatinib is lacking. We present our experience with three clinical cases to illustrate the position of pemigatinib in the management of CCA and related toxicities.
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Covers all phases of original research: laboratory, animal and human/clinical studies, health economics and outcomes research, and postmarketing studies. Original research that shows positive or negative results are welcomed. Invited review articles may cover single-drug reviews, drug class reviews, latest advances in drug therapy, therapeutic-area reviews, place-in-therapy reviews, new pathways and classes of drugs. In addition, systematic reviews and meta-analyses are welcomed and may be published as original research if performed per accepted guidelines. Editorials of key topics and issues in drugs and therapeutics are welcomed. The Editor-in-Chief will also consider manuscripts of interest in areas such as technologies that support diagnosis, assessment and treatment. EQUATOR Network reporting guidelines should be followed for each article type. GPP3 Guidelines should be followed for any industry-sponsored manuscripts. Other Editorial sections may include Editorial, Case Report, Conference Report, Letter-to-the-Editor, Educational Section.
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