慢性肾病患者地诺单抗给药后严重低钙:1例报告

IF 1.7 4区医学 Q4 NEUROSCIENCES

Journal of musculoskeletal & neuronal interactions Pub Date : 2023-06-01

Eleni Kouroglou, Vasiliki Tsiama, Sofia Dionysopoulou, Georgios Gavriiloglou, Margarita Bora, Konstantinos Belis, Stella Proikaki, Christos Savvidis, Panagiota Giannou, Dimitrios Petras

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引用次数: 0

摘要

肾功能改变的患者在denosumab给药后发生低钙血症的风险增加。然而，有少数研究和病例报告描述了难以治疗的低钙血症。我们描述了一个严重的低钙血症的情况下，三剂量地诺单抗的管理，在一个年轻的狼疮性肾炎患者皮质类固醇覆盖和骨质减少。然而，需要更多的研究来得出导致这组患者发生严重低钙血症的因素的安全结论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Severe hypocalcemia after denosumab administration in a patient with chronic kidney disease: a case report.

本刊更多论文

Severe hypocalcemia after denosumab administration in a patient with chronic kidney disease: a case report.

Patients with altered kidney function are at increased risk of hypocalcemia after denosumab administration. There is however a small number of studies and case reports describing hypocalcemia refractory to treatment. We describe a case of severe hypocalcemia, after the administration of three doses of denosumab, in a young patient with lupus nephritis under corticosteroid coverage and osteopenia. However, more studies are needed in order to extract a safe conclusion about the factors that contribute to the development of severe hypocalcemia in this group of patients.

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来源期刊

Journal of musculoskeletal & neuronal interactions NEUROSCIENCES-PHYSIOLOGY

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Musculoskeletal and Neuronal Interactions (JMNI) is an academic journal dealing with the pathophysiology and treatment of musculoskeletal disorders. It is published quarterly (months of issue March, June, September, December). Its purpose is to publish original, peer-reviewed papers of research and clinical experience in all areas of the musculoskeletal system and its interactions with the nervous system, especially metabolic bone diseases, with particular emphasis on osteoporosis. Additionally, JMNI publishes the Abstracts from the biannual meetings of the International Society of Musculoskeletal and Neuronal Interactions, and hosts Abstracts of other meetings on topics related to the aims and scope of JMNI.