肥厚型心肌病患者的心率变异性和血液动力学功能。

IF 1.3 4区 医学 Q4 PHYSIOLOGY
Alaa I. Alyahya, Sarah J. Charman, Nduka C. Okwose, Amy S. Fuller, Christopher Eggett, Peter Luke, Kristian Bailey, Guy A. MacGowan, Djordje G. Jakovljevic
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引用次数: 1

摘要

目的:心率变异性(HRV)是衡量心脏自主功能的指标。本研究:(1)评估肥厚型心肌病(HCM)患者与健康对照组在HRV和血液动力学功能方面的差异;(2)确定肥厚型心肌病患者的HRV与血液动力学变量之间的关系 = 7,女性;54岁 ± 15年;体重指数:29 ± 5. kg/m2)和28个匹配的健康个体(n = 女性7例;54岁 ± 16年;体重指数:29 ± 5. kg/m2)在静息(仰卧)条件下使用生物阻抗技术完成了5分钟的HRV和血液动力学测量。记录频域HRV测量(绝对和归一化低频功率(LF)、高频功率(HF)和LF/HF比)和RR间隔。结果:HCM患者表现出较高的迷走神经活动(即HF功率的绝对单位(7.40 ± 2.50对6.03 ± 1.35 ms2,p = 0.01),但RR间期较低(914 ± 178对1014 ± 168 ms,p = 0.03)。HCM患者的卒中量(SV)指数和心脏指数低于健康人(SV,33 ± 9对43 ± 7. ml‎/击败‎/m²,p 2,p 2厘米-5,p = HF功率与SV(r = -0.46,p 结论:HRV的短期频域指标为评估HCM患者的自主神经功能提供了一种可行的方法。以HF功率为代表的迷走神经活动增加,并与HCM患者的外周阻力有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Heart rate variability and haemodynamic function in individuals with hypertrophic cardiomyopathy

Objectives

Heart rate variability (HRV) is a measure of cardiac autonomic function. This study: (1) evaluated the differences in HRV and haemodynamic function between individuals with hypertrophic cardiomyopathy (HCM) and healthy controls, and (2) determined the relationship between HRV and haemodynamic variables in individuals with HCM.

Methods

Twenty-eight individuals with HCM (n = 7, females; age 54 ± 15 years; body mass index: 29 ± 5 kg/m2) and 28 matched healthy individuals (n = 7 females; age 54 ± 16 years; body mass index: 29 ± 5 kg/m2) completed 5-min HRV and haemodynamic measurements under resting (supine) conditions using bioimpedance technology. Frequency domain HRV measures (absolute and normalized low-frequency power (LF), high-frequency power (HF) and LF/HF ratio) and RR interval were recorded.

Results

Individuals with HCM demonstrated higher vagal activity (i.e., absolute unit of HF power (7.40 ± 2.50 vs. 6.03 ± 1.35 ms2, p = 0.01) but lower RR interval (914 ± 178 vs. 1014 ± 168 ms, p = 0.03) compared to controls. Stroke volume (SV) index and cardiac index were lower in HCM compared with healthy individuals (SV, 33 ± 9 vs. 43 ± 7 ml‎/beat‎/m², p < 0.01; cardiac index,2.33 ± 0.42 vs. 3.57 ± 0.82 L/min/m2, p < 0.01), but total peripheral resistance (TPR) was higher in HCM (3468 ± 1027 vs. 2953 ± 1050 dyn·s·m2cm5, p = 0.03). HF power was significantly related to SV (r = −0.46, p < 0.01) and TPR (r = 0.28, p < 0.05) in HCM.

Conclusions

Short-term frequency domain indices of HRV provide a feasible approach to assess autonomic function in individuals with HCM. Vagal activity, represented by HF power, is increased, and associated with peripheral resistance in individuals with HCM.

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来源期刊
CiteScore
3.40
自引率
5.60%
发文量
62
审稿时长
6-12 weeks
期刊介绍: Clinical Physiology and Functional Imaging publishes reports on clinical and experimental research pertinent to human physiology in health and disease. The scope of the Journal is very broad, covering all aspects of the regulatory system in the cardiovascular, renal and pulmonary systems with special emphasis on methodological aspects. The focus for the journal is, however, work that has potential clinical relevance. The Journal also features review articles on recent front-line research within these fields of interest. Covered by the major abstracting services including Current Contents and Science Citation Index, Clinical Physiology and Functional Imaging plays an important role in providing effective and productive communication among clinical physiologists world-wide.
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