Alaa I. Alyahya, Sarah J. Charman, Nduka C. Okwose, Amy S. Fuller, Christopher Eggett, Peter Luke, Kristian Bailey, Guy A. MacGowan, Djordje G. Jakovljevic
{"title":"肥厚型心肌病患者的心率变异性和血液动力学功能。","authors":"Alaa I. Alyahya, Sarah J. Charman, Nduka C. Okwose, Amy S. Fuller, Christopher Eggett, Peter Luke, Kristian Bailey, Guy A. MacGowan, Djordje G. Jakovljevic","doi":"10.1111/cpf.12840","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objectives</h3>\n \n <p>Heart rate variability (HRV) is a measure of cardiac autonomic function. This study: (1) evaluated the differences in HRV and haemodynamic function between individuals with hypertrophic cardiomyopathy (HCM) and healthy controls, and (2) determined the relationship between HRV and haemodynamic variables in individuals with HCM.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Twenty-eight individuals with HCM (<i>n</i> = 7, females; age 54 ± 15 years; body mass index: 29 ± 5 kg/m<sup>2</sup>) and 28 matched healthy individuals (<i>n</i> = 7 females; age 54 ± 16 years; body mass index: 29 ± 5 kg/m<sup>2</sup>) completed 5-min HRV and haemodynamic measurements under resting (supine) conditions using bioimpedance technology. Frequency domain HRV measures (absolute and normalized low-frequency power (LF), high-frequency power (HF) and LF/HF ratio) and RR interval were recorded.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Individuals with HCM demonstrated higher vagal activity (i.e., absolute unit of HF power (7.40 ± 2.50 vs. 6.03 ± 1.35 ms<sup>2</sup>, <i>p</i> = 0.01) but lower RR interval (914 ± 178 vs. 1014 ± 168 ms, <i>p</i> = 0.03) compared to controls. Stroke volume (SV) index and cardiac index were lower in HCM compared with healthy individuals (SV, 33 ± 9 vs. 43 ± 7 ml/beat/m², <i>p</i> < 0.01; cardiac index,2.33 ± 0.42 vs. 3.57 ± 0.82 L/min/m<sup>2</sup>, <i>p</i> < 0.01), but total peripheral resistance (TPR) was higher in HCM (3468 ± 1027 vs. 2953 ± 1050 dyn·s<i>·m</i><sup><i>2</i></sup>cm<sup><i>−</i>5</sup>, <i>p</i> = 0.03). HF power was significantly related to SV (<i>r</i> = −0.46, <i>p</i> < 0.01) and TPR (<i>r</i> = 0.28, <i>p</i> < 0.05) in HCM.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Short-term frequency domain indices of HRV provide a feasible approach to assess autonomic function in individuals with HCM. Vagal activity, represented by HF power, is increased, and associated with peripheral resistance in individuals with HCM.</p>\n </section>\n </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"43 6","pages":"421-430"},"PeriodicalIF":1.3000,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Heart rate variability and haemodynamic function in individuals with hypertrophic cardiomyopathy\",\"authors\":\"Alaa I. Alyahya, Sarah J. Charman, Nduka C. Okwose, Amy S. Fuller, Christopher Eggett, Peter Luke, Kristian Bailey, Guy A. MacGowan, Djordje G. Jakovljevic\",\"doi\":\"10.1111/cpf.12840\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objectives</h3>\\n \\n <p>Heart rate variability (HRV) is a measure of cardiac autonomic function. This study: (1) evaluated the differences in HRV and haemodynamic function between individuals with hypertrophic cardiomyopathy (HCM) and healthy controls, and (2) determined the relationship between HRV and haemodynamic variables in individuals with HCM.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Twenty-eight individuals with HCM (<i>n</i> = 7, females; age 54 ± 15 years; body mass index: 29 ± 5 kg/m<sup>2</sup>) and 28 matched healthy individuals (<i>n</i> = 7 females; age 54 ± 16 years; body mass index: 29 ± 5 kg/m<sup>2</sup>) completed 5-min HRV and haemodynamic measurements under resting (supine) conditions using bioimpedance technology. Frequency domain HRV measures (absolute and normalized low-frequency power (LF), high-frequency power (HF) and LF/HF ratio) and RR interval were recorded.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Individuals with HCM demonstrated higher vagal activity (i.e., absolute unit of HF power (7.40 ± 2.50 vs. 6.03 ± 1.35 ms<sup>2</sup>, <i>p</i> = 0.01) but lower RR interval (914 ± 178 vs. 1014 ± 168 ms, <i>p</i> = 0.03) compared to controls. Stroke volume (SV) index and cardiac index were lower in HCM compared with healthy individuals (SV, 33 ± 9 vs. 43 ± 7 ml/beat/m², <i>p</i> < 0.01; cardiac index,2.33 ± 0.42 vs. 3.57 ± 0.82 L/min/m<sup>2</sup>, <i>p</i> < 0.01), but total peripheral resistance (TPR) was higher in HCM (3468 ± 1027 vs. 2953 ± 1050 dyn·s<i>·m</i><sup><i>2</i></sup>cm<sup><i>−</i>5</sup>, <i>p</i> = 0.03). HF power was significantly related to SV (<i>r</i> = −0.46, <i>p</i> < 0.01) and TPR (<i>r</i> = 0.28, <i>p</i> < 0.05) in HCM.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Short-term frequency domain indices of HRV provide a feasible approach to assess autonomic function in individuals with HCM. Vagal activity, represented by HF power, is increased, and associated with peripheral resistance in individuals with HCM.</p>\\n </section>\\n </div>\",\"PeriodicalId\":10504,\"journal\":{\"name\":\"Clinical Physiology and Functional Imaging\",\"volume\":\"43 6\",\"pages\":\"421-430\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2023-06-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Physiology and Functional Imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/cpf.12840\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Physiology and Functional Imaging","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/cpf.12840","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
Heart rate variability and haemodynamic function in individuals with hypertrophic cardiomyopathy
Objectives
Heart rate variability (HRV) is a measure of cardiac autonomic function. This study: (1) evaluated the differences in HRV and haemodynamic function between individuals with hypertrophic cardiomyopathy (HCM) and healthy controls, and (2) determined the relationship between HRV and haemodynamic variables in individuals with HCM.
Methods
Twenty-eight individuals with HCM (n = 7, females; age 54 ± 15 years; body mass index: 29 ± 5 kg/m2) and 28 matched healthy individuals (n = 7 females; age 54 ± 16 years; body mass index: 29 ± 5 kg/m2) completed 5-min HRV and haemodynamic measurements under resting (supine) conditions using bioimpedance technology. Frequency domain HRV measures (absolute and normalized low-frequency power (LF), high-frequency power (HF) and LF/HF ratio) and RR interval were recorded.
Results
Individuals with HCM demonstrated higher vagal activity (i.e., absolute unit of HF power (7.40 ± 2.50 vs. 6.03 ± 1.35 ms2, p = 0.01) but lower RR interval (914 ± 178 vs. 1014 ± 168 ms, p = 0.03) compared to controls. Stroke volume (SV) index and cardiac index were lower in HCM compared with healthy individuals (SV, 33 ± 9 vs. 43 ± 7 ml/beat/m², p < 0.01; cardiac index,2.33 ± 0.42 vs. 3.57 ± 0.82 L/min/m2, p < 0.01), but total peripheral resistance (TPR) was higher in HCM (3468 ± 1027 vs. 2953 ± 1050 dyn·s·m2cm−5, p = 0.03). HF power was significantly related to SV (r = −0.46, p < 0.01) and TPR (r = 0.28, p < 0.05) in HCM.
Conclusions
Short-term frequency domain indices of HRV provide a feasible approach to assess autonomic function in individuals with HCM. Vagal activity, represented by HF power, is increased, and associated with peripheral resistance in individuals with HCM.
期刊介绍：
Clinical Physiology and Functional Imaging publishes reports on clinical and experimental research pertinent to human physiology in health and disease. The scope of the Journal is very broad, covering all aspects of the regulatory system in the cardiovascular, renal and pulmonary systems with special emphasis on methodological aspects. The focus for the journal is, however, work that has potential clinical relevance. The Journal also features review articles on recent front-line research within these fields of interest.
Covered by the major abstracting services including Current Contents and Science Citation Index, Clinical Physiology and Functional Imaging plays an important role in providing effective and productive communication among clinical physiologists world-wide.
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