Muhammad Shaiq Ali, Seerat Iqbal, Mehreen Lateef, Ngoupayo Joseph
{"title":"从薯蓣中提取的一种新的脲酶抑制查尔酮。","authors":"Muhammad Shaiq Ali, Seerat Iqbal, Mehreen Lateef, Ngoupayo Joseph","doi":"10.1080/14786419.2023.2248350","DOIUrl":null,"url":null,"abstract":"<p><p>The phytochemical investigation of the aqueous methanolic extract of the aerial parts of <i>Dioscorea preussii,</i> led to the isolation of a new chalcone preussiate (<b>1</b>) along with 10 other compounds including xanthomicrol (<b>2</b>), cholestan-3-one (<b>3</b>), arjunolic acid (<b>4</b>), tormentic acid (<b>5</b>), ursolic acid (<b>6</b>), betulin (<b>7)</b>, lupeol (<b>8</b>), p-hydroxybenzoic acid (<b>9</b>), isovanillin (<b>10</b>) and vanillic acid (<b>11</b>), being reported for the first time from this plant. Their structures were established by spectroscopic techniques including 2D NMR spectroscopy. All the isolates were subjected to the biological screening but only showed antioxidant and urease inhibitory properties. The compounds <b>1</b>,<b>8</b> and <b>11</b> displayed the most potent urease inhibitory properties with IC<sub>50</sub> values, 22.4<sub>,</sub> 33.3 and 35.7 µM, respectively, while <b>3</b> was moderately active. The compound <b>11</b> showed potent antioxidant activity among all the tested isolates with an IC<sub>50</sub> value of 45.3 µM.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.9000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Preussiate, a new urease inhibitory chalcone from <i>Dioscorea preussii</i> Pax.\",\"authors\":\"Muhammad Shaiq Ali, Seerat Iqbal, Mehreen Lateef, Ngoupayo Joseph\",\"doi\":\"10.1080/14786419.2023.2248350\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The phytochemical investigation of the aqueous methanolic extract of the aerial parts of <i>Dioscorea preussii,</i> led to the isolation of a new chalcone preussiate (<b>1</b>) along with 10 other compounds including xanthomicrol (<b>2</b>), cholestan-3-one (<b>3</b>), arjunolic acid (<b>4</b>), tormentic acid (<b>5</b>), ursolic acid (<b>6</b>), betulin (<b>7)</b>, lupeol (<b>8</b>), p-hydroxybenzoic acid (<b>9</b>), isovanillin (<b>10</b>) and vanillic acid (<b>11</b>), being reported for the first time from this plant. Their structures were established by spectroscopic techniques including 2D NMR spectroscopy. All the isolates were subjected to the biological screening but only showed antioxidant and urease inhibitory properties. The compounds <b>1</b>,<b>8</b> and <b>11</b> displayed the most potent urease inhibitory properties with IC<sub>50</sub> values, 22.4<sub>,</sub> 33.3 and 35.7 µM, respectively, while <b>3</b> was moderately active. The compound <b>11</b> showed potent antioxidant activity among all the tested isolates with an IC<sub>50</sub> value of 45.3 µM.</p>\",\"PeriodicalId\":18990,\"journal\":{\"name\":\"Natural Product Research\",\"volume\":\" \",\"pages\":\"1-8\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1080/14786419.2023.2248350\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/8/21 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2023.2248350","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/8/21 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Preussiate, a new urease inhibitory chalcone from Dioscorea preussii Pax.
The phytochemical investigation of the aqueous methanolic extract of the aerial parts of Dioscorea preussii, led to the isolation of a new chalcone preussiate (1) along with 10 other compounds including xanthomicrol (2), cholestan-3-one (3), arjunolic acid (4), tormentic acid (5), ursolic acid (6), betulin (7), lupeol (8), p-hydroxybenzoic acid (9), isovanillin (10) and vanillic acid (11), being reported for the first time from this plant. Their structures were established by spectroscopic techniques including 2D NMR spectroscopy. All the isolates were subjected to the biological screening but only showed antioxidant and urease inhibitory properties. The compounds 1,8 and 11 displayed the most potent urease inhibitory properties with IC50 values, 22.4, 33.3 and 35.7 µM, respectively, while 3 was moderately active. The compound 11 showed potent antioxidant activity among all the tested isolates with an IC50 value of 45.3 µM.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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