质膜H+-ATP酶和V-ATP酶对病原真菌生长和致病性的意义。

2区 生物学 Q1 Immunology and Microbiology
Advances in applied microbiology Pub Date : 2023-01-01 Epub Date: 2023-07-28 DOI:10.1016/bs.aambs.2023.07.001
S Z Yang, L T Peng
{"title":"质膜H+-ATP酶和V-ATP酶对病原真菌生长和致病性的意义。","authors":"S Z Yang,&nbsp;L T Peng","doi":"10.1016/bs.aambs.2023.07.001","DOIUrl":null,"url":null,"abstract":"<p><p>Pathogenic fungi are widespread and cause a variety of diseases in human beings and other organisms. At present, limited classes of antifungal agents are available to treat invasive fungal diseases. With the wide use of the commercial antifungal agents, drug resistance of pathogenic fungi are continuously increasing. Therefore, exploring effective antifungal agents with novel drug targets is urgently needed to cope with the challenges that the antifungal area faces. pH homeostasis is vital for multiple cellular processes, revealing the potential for defining novel drug targets. Fungi have evolved a number of strategies to maintain a stable pH internal environment in response to rapid metabolism and a dramatically changing extracellular environment. Among them, plasma membrane H<sup>+</sup>-ATPase (PMA) and vacuolar H<sup>+</sup>-ATPase (V-ATPase) play a central role in the regulation of pH homeostasis system. In this chapter, we will summarize the current knowledge about pH homeostasis and its regulation mechanisms in pathogenic fungi, especially for the recent advances in PMA and V-ATPase, which would help in revealing the regulating mechanism of pH on cell growth and pathogenicity, and further designing effective drugs and identify new targets for combating fungal diseases.</p>","PeriodicalId":7298,"journal":{"name":"Advances in applied microbiology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Significance of the plasma membrane H<sup>+</sup>-ATPase and V-ATPase for growth and pathogenicity in pathogenic fungi.\",\"authors\":\"S Z Yang,&nbsp;L T Peng\",\"doi\":\"10.1016/bs.aambs.2023.07.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Pathogenic fungi are widespread and cause a variety of diseases in human beings and other organisms. At present, limited classes of antifungal agents are available to treat invasive fungal diseases. With the wide use of the commercial antifungal agents, drug resistance of pathogenic fungi are continuously increasing. Therefore, exploring effective antifungal agents with novel drug targets is urgently needed to cope with the challenges that the antifungal area faces. pH homeostasis is vital for multiple cellular processes, revealing the potential for defining novel drug targets. Fungi have evolved a number of strategies to maintain a stable pH internal environment in response to rapid metabolism and a dramatically changing extracellular environment. Among them, plasma membrane H<sup>+</sup>-ATPase (PMA) and vacuolar H<sup>+</sup>-ATPase (V-ATPase) play a central role in the regulation of pH homeostasis system. In this chapter, we will summarize the current knowledge about pH homeostasis and its regulation mechanisms in pathogenic fungi, especially for the recent advances in PMA and V-ATPase, which would help in revealing the regulating mechanism of pH on cell growth and pathogenicity, and further designing effective drugs and identify new targets for combating fungal diseases.</p>\",\"PeriodicalId\":7298,\"journal\":{\"name\":\"Advances in applied microbiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in applied microbiology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1016/bs.aambs.2023.07.001\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/7/28 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"Immunology and Microbiology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in applied microbiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/bs.aambs.2023.07.001","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/7/28 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"Immunology and Microbiology","Score":null,"Total":0}
引用次数: 0

摘要

病原真菌在人类和其他生物中广泛存在并引起多种疾病。目前,可用于治疗侵袭性真菌疾病的抗真菌药物种类有限。随着商业抗真菌药物的广泛使用,病原真菌的耐药性不断增加。因此,迫切需要探索具有新药物靶点的有效抗真菌药物,以应对抗真菌领域面临的挑战。pH稳态对多种细胞过程至关重要,揭示了确定新药物靶点的潜力。真菌已经进化出许多策略来维持稳定的pH内部环境,以应对快速代谢和急剧变化的细胞外环境。其中,质膜H+-ATPase(PMA)和液泡H+-ATP酶(V-ATPase)在调节pH稳态系统中起着核心作用。在本章中,我们将总结目前关于病原真菌pH稳态及其调控机制的知识,特别是PMA和V-ATP酶的最新进展,这将有助于揭示pH对细胞生长和致病性的调控机制,并进一步设计有效的药物和确定抗真菌疾病的新靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Significance of the plasma membrane H+-ATPase and V-ATPase for growth and pathogenicity in pathogenic fungi.

Pathogenic fungi are widespread and cause a variety of diseases in human beings and other organisms. At present, limited classes of antifungal agents are available to treat invasive fungal diseases. With the wide use of the commercial antifungal agents, drug resistance of pathogenic fungi are continuously increasing. Therefore, exploring effective antifungal agents with novel drug targets is urgently needed to cope with the challenges that the antifungal area faces. pH homeostasis is vital for multiple cellular processes, revealing the potential for defining novel drug targets. Fungi have evolved a number of strategies to maintain a stable pH internal environment in response to rapid metabolism and a dramatically changing extracellular environment. Among them, plasma membrane H+-ATPase (PMA) and vacuolar H+-ATPase (V-ATPase) play a central role in the regulation of pH homeostasis system. In this chapter, we will summarize the current knowledge about pH homeostasis and its regulation mechanisms in pathogenic fungi, especially for the recent advances in PMA and V-ATPase, which would help in revealing the regulating mechanism of pH on cell growth and pathogenicity, and further designing effective drugs and identify new targets for combating fungal diseases.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Advances in applied microbiology
Advances in applied microbiology 生物-生物工程与应用微生物
CiteScore
8.20
自引率
0.00%
发文量
16
审稿时长
>12 weeks
期刊介绍: Advances in Applied Microbiology offers intensive reviews of the latest techniques and discoveries in this rapidly moving field. The editors are recognized experts and the format is comprehensive and instructive. Published since 1959, Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology. Recent areas covered include bacterial diversity in the human gut, protozoan grazing of freshwater biofilms, metals in yeast fermentation processes and the interpretation of host-pathogen dialogue through microarrays.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信