先天性淋巴细胞亚型 2 在各种肿瘤微环境中协调免疫反应,是癌症免疫疗法的合适靶点。

IF 4.3 4区 医学 Q2 IMMUNOLOGY
International Reviews of Immunology Pub Date : 2024-01-01 Epub Date: 2023-08-21 DOI:10.1080/08830185.2023.2247021
Rajdeep Roy, Tanmoy Das, Nabendu Biswas
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引用次数: 0

摘要

先天性淋巴细胞是一种混合细胞群,也是先天性免疫系统的关键调节因子。根据最近的科学文献,组织常驻先天性淋巴细胞亚型 2 被认为是第二类炎症反应的重要参与者,参与了胰腺癌、肺癌、急性髓性白血病、胃肠道癌等不同人类恶性肿瘤的治疗。目前的报告显示,在三种主要的 ILC 亚型中,亚型 2(ILC 2)是在肿瘤微环境(TME)中启动 2 型炎症反应的关键调节因子。激活 ILC-2 是 ILC-2 发挥特定下游功能的重要步骤。用不同的趋化因子激活 ILC-2,活化的 ILC-2 会分泌不同的细胞因子,如 IL-4、IL-5、IL-13、IL-9,从而诱发 2 型炎症反应,并与 NK 细胞、细胞毒性 T 细胞、MDSC 和 Treg 细胞等其他免疫细胞发生复杂的相互作用。在初期阶段,ILC-2 通过 IL-33 激活可能会诱导 ILC-2/ 嗜酸性粒细胞轴介导的抗肿瘤作用。然而,PDG2(前列腺素 D2)介导的 ILC-2 激活在 TME 诱导 ILC-2/MDSC 的免疫抑制促致癌龛也是显而易见的。在本综述中,我们根据最近的科学研究总结了ILC-2在癌症免疫中的功能,这些研究表明ILC-2在不同的癌症环境中扮演着双重角色,并协调着对2型免疫的免疫反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Orchestration of immune response by innate lymphoid cell subtype 2 at various tumor microenvironment, a suitable target for cancer immunotherapy.

Innate lymphoid cells are a mixed population of cells and critical regulators of our innate immune system. According to recent scientific literature, tissue resident innate lymphoid cell subtype 2 has been recognized as an important player of type 2 inflammatory responses, involved in different human malignancies like pancreatic, lung, acute myeloid leukemia, gastrointestinal tract cancer, etc. The current reports have revealed that, among the three main ILC sub types, subtype 2 (ILC 2), as the key regulator of initiating the type 2 inflammatory responses at the tumor microenvironment (TME). This activation of ILC-2 is a very important step for the specific downstream functioning of ILC-2. Priming of ILC-2 with different chemokines involves different cytokine secretion from the activated ILC-2 like IL-4, IL-5, IL-13, IL-9 which induce type 2 inflammatory responses involved in the complex interaction with other immune cells like NK cell, Cytotoxic T cell, MDSC and Treg cell. At the initial stage, ILC-2 activation through IL-33 may induce the anti-tumorigenic effect mediated by ILC-2/eosinophil axis. However, it is also evident that PDG2 (Prostaglandin D2)-mediated activation of ILC-2 induces the ILC-2/MDSC immune suppressive pro-tumorigenic niche at the TME. Here, in this review, we have summarized the function of ILC-2 on cancer immunity based on recent scientific work which indicates ILC-2 plays a dual role and orchestrates the immune responses toward type 2 immunity in different cancer settings.

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来源期刊
CiteScore
11.00
自引率
4.00%
发文量
24
期刊介绍: This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).
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