Fang Liu, Yudi Shi, Qiuyan Wu, Huifeng Chen, Ying Wang, Li Cai, Nan Zhang
{"title":"FDG 联合 PiB PET 在记忆诊所诊断认知障碍患者中的价值","authors":"Fang Liu, Yudi Shi, Qiuyan Wu, Huifeng Chen, Ying Wang, Li Cai, Nan Zhang","doi":"10.1111/cns.14418","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aims</h3>\n \n <p>To analyze the value of <sup>18</sup>F-fluorodeoxyglucose (FDG) positron emission tomography (PET) combined with amyloid PET in cognitive impairment diagnosis.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A total of 187 patients with dementia or mild cognitive impairment (MCI) who underwent <sup>11</sup>C-Pittsburgh compound B (PiB) and FDG PET scans in a memory clinic were included in the final analysis.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Amyloid-positive and amyloid-negative dementia patient groups showed a significant difference in the proportion of individuals presenting temporoparietal cortex (<i>p</i> < 0.001) and posterior cingulate/precuneus cortex (<i>p</i> < 0.001) hypometabolism. The sensitivity and specificity of this hypometabolic pattern for identifying amyloid pathology were 72.61% and 77.97%, respectively, in patients clinically diagnosed with AD and 60.87% and 76.19%, respectively, in patients with MCI. The initial diagnosis was changed in 32.17% of patients with dementia after considering both PiB and FDG results. There was a significant difference in both the proportion of patients showing the hypometabolic pattern and PiB positivity between dementia conversion patients and patients with a stable diagnosis of MCI (<i>p</i> < 0.05).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Temporoparietal and posterior cingulate/precuneus cortex hypometabolism on FDG PET suggested amyloid pathology in patients with cognitive impairment and is helpful in diagnostic decision-making and predicting AD dementia conversion from MCI, particularly when combined with amyloid PET.</p>\n </section>\n </div>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"30 2","pages":""},"PeriodicalIF":4.8000,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.14418","citationCount":"0","resultStr":"{\"title\":\"The value of FDG combined with PiB PET in the diagnosis of patients with cognitive impairment in a memory clinic\",\"authors\":\"Fang Liu, Yudi Shi, Qiuyan Wu, Huifeng Chen, Ying Wang, Li Cai, Nan Zhang\",\"doi\":\"10.1111/cns.14418\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Aims</h3>\\n \\n <p>To analyze the value of <sup>18</sup>F-fluorodeoxyglucose (FDG) positron emission tomography (PET) combined with amyloid PET in cognitive impairment diagnosis.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A total of 187 patients with dementia or mild cognitive impairment (MCI) who underwent <sup>11</sup>C-Pittsburgh compound B (PiB) and FDG PET scans in a memory clinic were included in the final analysis.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Amyloid-positive and amyloid-negative dementia patient groups showed a significant difference in the proportion of individuals presenting temporoparietal cortex (<i>p</i> < 0.001) and posterior cingulate/precuneus cortex (<i>p</i> < 0.001) hypometabolism. The sensitivity and specificity of this hypometabolic pattern for identifying amyloid pathology were 72.61% and 77.97%, respectively, in patients clinically diagnosed with AD and 60.87% and 76.19%, respectively, in patients with MCI. The initial diagnosis was changed in 32.17% of patients with dementia after considering both PiB and FDG results. 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The value of FDG combined with PiB PET in the diagnosis of patients with cognitive impairment in a memory clinic
Aims
To analyze the value of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) combined with amyloid PET in cognitive impairment diagnosis.
Methods
A total of 187 patients with dementia or mild cognitive impairment (MCI) who underwent 11C-Pittsburgh compound B (PiB) and FDG PET scans in a memory clinic were included in the final analysis.
Results
Amyloid-positive and amyloid-negative dementia patient groups showed a significant difference in the proportion of individuals presenting temporoparietal cortex (p < 0.001) and posterior cingulate/precuneus cortex (p < 0.001) hypometabolism. The sensitivity and specificity of this hypometabolic pattern for identifying amyloid pathology were 72.61% and 77.97%, respectively, in patients clinically diagnosed with AD and 60.87% and 76.19%, respectively, in patients with MCI. The initial diagnosis was changed in 32.17% of patients with dementia after considering both PiB and FDG results. There was a significant difference in both the proportion of patients showing the hypometabolic pattern and PiB positivity between dementia conversion patients and patients with a stable diagnosis of MCI (p < 0.05).
Conclusion
Temporoparietal and posterior cingulate/precuneus cortex hypometabolism on FDG PET suggested amyloid pathology in patients with cognitive impairment and is helpful in diagnostic decision-making and predicting AD dementia conversion from MCI, particularly when combined with amyloid PET.
期刊介绍：
CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.
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