靶向背根神经节和初级感觉神经元治疗慢性疼痛:最新进展。

IF 4.6 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Expert Opinion on Therapeutic Targets Pub Date : 2023-07-01 Epub Date: 2023-08-22 DOI:10.1080/14728222.2023.2247563
Temugin Berta, Judith A Strong, Jun-Ming Zhang, Ru-Rong Ji
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引用次数: 0

摘要

引言:目前对慢性疼痛的治疗是不够的。在这里,我们提供了针对外周神经系统背根神经节(DRG)的新治疗策略的更新,以更好、更安全地治疗慢性疼痛。涵盖的领域:尽管慢性疼痛及其潜在机制具有复杂的性质,但我们确实知道DRG神经元可塑性和形态的变化起着关键作用。DRG神经元是异质性的,为不同的治疗干预提供了潜在的疼痛靶点。我们讨论了这些干预措施的最新进展,包括使用全身和局部给药、选择性神经药物递送和基因治疗。特别是,我们提供了初级感觉神经元的分子特征、进入市场的新型止痛药以及未来基因治疗方法的更新和进一步的细节。专家意见:DRG和初级感觉神经元是慢性疼痛治疗的有前途的靶点,因为它们在疼痛信号传导中发挥着关键作用,具有独特的解剖位置,并且有可能进行不同的靶向治疗干预。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update.

Introduction: Current treatments for chronic pain are inadequate. Here, we provide an update on the new therapeutic strategies that target dorsal root ganglia (DRGs) in the peripheral nervous system for a better and safer treatment of chronic pain.

Areas covered: Despite the complex nature of chronic pain and its underlying mechanisms, we do know that changes in the plasticity and modality of neurons in DRGs play a pivotal role. DRG neurons are heterogenous and offer potential pain targets for different therapeutic interventions. We discuss the last advancements of these interventions, which include the use of systemic and local administrations, selective nerve drug delivery, and gene therapy. In particular, we provide updates and further details on the molecular characterization of primary sensory neurons, new analgesics entering the market, and future gene therapy approaches.

Expert opinion: DRGs and primary sensory neurons are promising targets for chronic pain treatment due to their key role in pain signaling, unique anatomical location, and the potential for different targeted therapeutic interventions.

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来源期刊
CiteScore
8.90
自引率
1.70%
发文量
58
审稿时长
3 months
期刊介绍: The journal evaluates molecules, signalling pathways, receptors and other therapeutic targets and their potential as candidates for drug development. Articles in this journal focus on the molecular level and early preclinical studies. Articles should not include clinical information including specific drugs and clinical trials. The Editors welcome: Reviews covering novel disease targets at the molecular level and information on early preclinical studies and their implications for future drug development. Articles should not include clinical information including specific drugs and clinical trials. Original research papers reporting results of target selection and validation studies and basic mechanism of action studies for investigative and marketed drugs. The audience consists of scientists, managers and decision makers in the pharmaceutical industry, academic researchers working in the field of molecular medicine and others closely involved in R&D.
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