ATP敏感性钾通道：神经退行性变的治疗靶点？

IF 4.6 2区医学 Q1 PHARMACOLOGY & PHARMACY

Expert Opinion on Therapeutic Targets Pub Date : 2023-07-01 Epub Date: 2023-08-01 DOI:10.1080/14728222.2023.2240023

Xue Xiao, Mingxia Bi, Xixun Du, Hong Jiang

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The ATP-sensitive potassium channel: a therapeutic target for neurodegeneration?

In 1983, NOMA first discovered ATP sensitive potassium channels (KATP channels) through patch clamp technology, which are widely distributed in the brain and can couple cell energy states and electrical activities. KATP channels remain in a closed state under normal physiological conditions, however, KATP channels are selectively activated in pathological state [1]. Although a large number of literatures has reported that KATP channels are involved in the occurrence and development of neurodegenerative diseases, the mechanism of its role has not yet been clarified [2]. It is of great significance to further explore the important role of KATP channels and the related drugs in neurodegenerative diseases.

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来源期刊

Expert Opinion on Therapeutic Targets 医学-药学

CiteScore

8.90

自引率

1.70%

发文量

审稿时长

3 months

期刊介绍： The journal evaluates molecules, signalling pathways, receptors and other therapeutic targets and their potential as candidates for drug development. Articles in this journal focus on the molecular level and early preclinical studies. Articles should not include clinical information including specific drugs and clinical trials. The Editors welcome: Reviews covering novel disease targets at the molecular level and information on early preclinical studies and their implications for future drug development. Articles should not include clinical information including specific drugs and clinical trials. Original research papers reporting results of target selection and validation studies and basic mechanism of action studies for investigative and marketed drugs. The audience consists of scientists, managers and decision makers in the pharmaceutical industry, academic researchers working in the field of molecular medicine and others closely involved in R&D.