Jonas Liefke, Alvaro Sepúlveda-Martinez, Snehlata Shakya, Katarina Steding Ehrenborg, Håkan Arheden, Eva Morsing, David Ley, Einar Heiberg, Erik Hedström
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Seventy adolescents were included (13-16 years; 49% males). Sphericity was increased for preterm FGR versus term AGA for end-diastole (36[0-60] vs - 42[- 82-8]; p = 0.01) and the combined analysis (27[- 23-94] vs - 51[- 119-11]; p = 0.01), as well as for preterm AGA versus term AGA for end-diastole (30[- 56-115] vs - 42[- 82-8]; p = 0.04), for end-systole (57[- 29-89] vs - 30[- 79-34]; p = 0.03), and the combined analysis (44[- 50-145] vs - 51[- 119-11]; p = 0.02). No group differences were observed for left ventricular mass or ejection fraction (all p ≥ 0.33). Sphericity was increased after very preterm birth and exacerbated by early-onset FGR, indicating an additive effect to that of very preterm birth on left ventricular remodeling. Increased sphericity may be a prognostic biomarker of future cardiovascular disease in this cohort that as of yet shows no signs of cardiac dysfunction using standard clinical measurements.</p>","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442571/pdf/","citationCount":"0","resultStr":"{\"title\":\"Early-Onset Fetal Growth Restriction Increases Left Ventricular Sphericity in Adolescents Born Very Preterm.\",\"authors\":\"Jonas Liefke, Alvaro Sepúlveda-Martinez, Snehlata Shakya, Katarina Steding Ehrenborg, Håkan Arheden, Eva Morsing, David Ley, Einar Heiberg, Erik Hedström\",\"doi\":\"10.1007/s00246-023-03265-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Left ventricular shape alterations predict cardiovascular outcomes and have been observed in children born preterm and after fetal growth restriction (FGR). 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引用次数: 0
摘要
左心室形态的改变可预测心血管疾病的预后,在早产儿和胎儿生长受限(FGR)后的儿童中也观察到了这种改变。该研究旨在探讨早产青少年的左心室形态是否会发生改变,以及胎儿生长受限是否会产生叠加效应。因早产儿FGR而被证实为极早产儿的青少年和两组出生体重符合胎龄(AGA)、胎龄相近和足月出生的对照组分别接受了心脏磁共振成像检查。采用主成分分析法找出最能解释舒张末期、收缩末期和两者结合的形状变化的变异模式,后者表明了功能。研究对象包括 70 名青少年(13-16 岁;49% 为男性)。在舒张末(36[0-60] vs - 42[-82-8];p = 0.01)和综合分析(27[- 23-94] vs - 51[-119-11];p = 0.01)中,早产 FGR 与足月 AGA 的球形度增加。01),以及早产 AGA 与足月 AGA 在舒张末(30[- 56-115] vs - 42[-82-8];p = 0.04)、收缩末(57[- 29-89] vs - 30[-79-34];p = 0.03)和合并分析(44[- 50-145] vs - 51[-119-11];p = 0.02)方面的差异。在左心室质量或射血分数方面没有观察到组间差异(均 p ≥ 0.33)。球形度在极早产后增加,并因早发FGR而加剧,这表明极早产对左心室重塑具有叠加效应。在这个队列中,球形度的增加可能是未来心血管疾病的预后生物标志物,而目前使用标准的临床测量方法还没有显示出心功能不全的迹象。
Early-Onset Fetal Growth Restriction Increases Left Ventricular Sphericity in Adolescents Born Very Preterm.
Left ventricular shape alterations predict cardiovascular outcomes and have been observed in children born preterm and after fetal growth restriction (FGR). The aim was to investigate whether left ventricular shape is altered in adolescents born very preterm and if FGR has an additive effect. Adolescents born very preterm due to verified early-onset FGR and two control groups with birthweight appropriate for gestational age (AGA), born at similar gestational age and at term, respectively, underwent cardiac MRI. Principal component analysis was applied to find the modes of variation best explaining shape variability for end-diastole, end-systole, and for the combination of both, the latter indicative of function. Seventy adolescents were included (13-16 years; 49% males). Sphericity was increased for preterm FGR versus term AGA for end-diastole (36[0-60] vs - 42[- 82-8]; p = 0.01) and the combined analysis (27[- 23-94] vs - 51[- 119-11]; p = 0.01), as well as for preterm AGA versus term AGA for end-diastole (30[- 56-115] vs - 42[- 82-8]; p = 0.04), for end-systole (57[- 29-89] vs - 30[- 79-34]; p = 0.03), and the combined analysis (44[- 50-145] vs - 51[- 119-11]; p = 0.02). No group differences were observed for left ventricular mass or ejection fraction (all p ≥ 0.33). Sphericity was increased after very preterm birth and exacerbated by early-onset FGR, indicating an additive effect to that of very preterm birth on left ventricular remodeling. Increased sphericity may be a prognostic biomarker of future cardiovascular disease in this cohort that as of yet shows no signs of cardiac dysfunction using standard clinical measurements.
期刊介绍:
The editor of Pediatric Cardiology welcomes original manuscripts concerning all aspects of heart disease in infants, children, and adolescents, including embryology and anatomy, physiology and pharmacology, biochemistry, pathology, genetics, radiology, clinical aspects, investigative cardiology, electrophysiology and echocardiography, and cardiac surgery. Articles which may include original articles, review articles, letters to the editor etc., must be written in English and must be submitted solely to Pediatric Cardiology.