Omar F Khabour, Sawsan Abuhammad, Karem H Alzoubi, Ahmad S Alkofahi
{"title":"芫荽和三叶萝藦能保护癌症的发展：利用小鼠绘画试验进行的体内研究","authors":"Omar F Khabour, Sawsan Abuhammad, Karem H Alzoubi, Ahmad S Alkofahi","doi":"10.2174/1568009623666230817101757","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>The aim of this study is to examine the protective properties of <i>Coriandrum sativum</i> and <i>Aloysia triphylla</i> against the development of skin cancer.</p><p><strong>Methods: </strong>The skin cancer balb/c mouse model was utilized in the study. Plant extracts were administered to animals using oral gavage. In addition, skin cancer was induced using 7,12-dimethylbenz( a) anthracene (DMBA).</p><p><strong>Results: </strong>The study found that <i>A. triphylla</i> extract reduced both tumor incidence (P<0.01) and papilloma frequency (<i>P</i><0.001) and delayed the onset of tumor development (<i>P</i><0.001). The <i>A. triphylla</i> extract did not affect tumor size in animals. <i>C. sativum</i> leaf extract reduced the number of tumors per animal, the incidence of tumors, and the frequency of papilloma (<i>P</i><0.05). In addition, it delayed (<i>P</i><0.01) the onset of tumors. Treatment of animals with <i>C. sativum</i> seed extract reduced the frequency of papilloma (P<0.05) and delayed the onset of tumors (<i>P</i><0.05). However, the examined plant extracts did not impact the size of tumors induced by DMBA (<i>P</i>>0.05).</p><p><strong>Conclusion: </strong>The findings of this study revealed that <i>C. sativum</i> and<i> A. triphylla</i> could protect against cancer development as indicated using the animal model of skin painting assay.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"<i>Coriandrum sativum</i> and <i>Aloysia triphylla</i> can Protect the Development of Cancer: An in Vivo Study using Mouse Painting Assay.\",\"authors\":\"Omar F Khabour, Sawsan Abuhammad, Karem H Alzoubi, Ahmad S Alkofahi\",\"doi\":\"10.2174/1568009623666230817101757\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>The aim of this study is to examine the protective properties of <i>Coriandrum sativum</i> and <i>Aloysia triphylla</i> against the development of skin cancer.</p><p><strong>Methods: </strong>The skin cancer balb/c mouse model was utilized in the study. Plant extracts were administered to animals using oral gavage. In addition, skin cancer was induced using 7,12-dimethylbenz( a) anthracene (DMBA).</p><p><strong>Results: </strong>The study found that <i>A. triphylla</i> extract reduced both tumor incidence (P<0.01) and papilloma frequency (<i>P</i><0.001) and delayed the onset of tumor development (<i>P</i><0.001). The <i>A. triphylla</i> extract did not affect tumor size in animals. <i>C. sativum</i> leaf extract reduced the number of tumors per animal, the incidence of tumors, and the frequency of papilloma (<i>P</i><0.05). In addition, it delayed (<i>P</i><0.01) the onset of tumors. Treatment of animals with <i>C. sativum</i> seed extract reduced the frequency of papilloma (P<0.05) and delayed the onset of tumors (<i>P</i><0.05). However, the examined plant extracts did not impact the size of tumors induced by DMBA (<i>P</i>>0.05).</p><p><strong>Conclusion: </strong>The findings of this study revealed that <i>C. sativum</i> and<i> A. triphylla</i> could protect against cancer development as indicated using the animal model of skin painting assay.</p>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2174/1568009623666230817101757\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/1568009623666230817101757","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Coriandrum sativum and Aloysia triphylla can Protect the Development of Cancer: An in Vivo Study using Mouse Painting Assay.
Aim: The aim of this study is to examine the protective properties of Coriandrum sativum and Aloysia triphylla against the development of skin cancer.
Methods: The skin cancer balb/c mouse model was utilized in the study. Plant extracts were administered to animals using oral gavage. In addition, skin cancer was induced using 7,12-dimethylbenz( a) anthracene (DMBA).
Results: The study found that A. triphylla extract reduced both tumor incidence (P<0.01) and papilloma frequency (P<0.001) and delayed the onset of tumor development (P<0.001). The A. triphylla extract did not affect tumor size in animals. C. sativum leaf extract reduced the number of tumors per animal, the incidence of tumors, and the frequency of papilloma (P<0.05). In addition, it delayed (P<0.01) the onset of tumors. Treatment of animals with C. sativum seed extract reduced the frequency of papilloma (P<0.05) and delayed the onset of tumors (P<0.05). However, the examined plant extracts did not impact the size of tumors induced by DMBA (P>0.05).
Conclusion: The findings of this study revealed that C. sativum and A. triphylla could protect against cancer development as indicated using the animal model of skin painting assay.
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