Omar F Khabour, Sawsan Abuhammad, Karem H Alzoubi, Ahmad S Alkofahi
{"title":"芫荽和三叶萝藦能保护癌症的发展：利用小鼠绘画试验进行的体内研究","authors":"Omar F Khabour, Sawsan Abuhammad, Karem H Alzoubi, Ahmad S Alkofahi","doi":"10.2174/1568009623666230817101757","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>The aim of this study is to examine the protective properties of <i>Coriandrum sativum</i> and <i>Aloysia triphylla</i> against the development of skin cancer.</p><p><strong>Methods: </strong>The skin cancer balb/c mouse model was utilized in the study. Plant extracts were administered to animals using oral gavage. In addition, skin cancer was induced using 7,12-dimethylbenz( a) anthracene (DMBA).</p><p><strong>Results: </strong>The study found that <i>A. triphylla</i> extract reduced both tumor incidence (P<0.01) and papilloma frequency (<i>P</i><0.001) and delayed the onset of tumor development (<i>P</i><0.001). The <i>A. triphylla</i> extract did not affect tumor size in animals. <i>C. sativum</i> leaf extract reduced the number of tumors per animal, the incidence of tumors, and the frequency of papilloma (<i>P</i><0.05). In addition, it delayed (<i>P</i><0.01) the onset of tumors. Treatment of animals with <i>C. sativum</i> seed extract reduced the frequency of papilloma (P<0.05) and delayed the onset of tumors (<i>P</i><0.05). However, the examined plant extracts did not impact the size of tumors induced by DMBA (<i>P</i>>0.05).</p><p><strong>Conclusion: </strong>The findings of this study revealed that <i>C. sativum</i> and<i> A. triphylla</i> could protect against cancer development as indicated using the animal model of skin painting assay.</p>","PeriodicalId":10816,"journal":{"name":"Current cancer drug targets","volume":" ","pages":"455-462"},"PeriodicalIF":2.3000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"<i>Coriandrum sativum</i> and <i>Aloysia triphylla</i> can Protect the Development of Cancer: An in Vivo Study using Mouse Painting Assay.\",\"authors\":\"Omar F Khabour, Sawsan Abuhammad, Karem H Alzoubi, Ahmad S Alkofahi\",\"doi\":\"10.2174/1568009623666230817101757\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>The aim of this study is to examine the protective properties of <i>Coriandrum sativum</i> and <i>Aloysia triphylla</i> against the development of skin cancer.</p><p><strong>Methods: </strong>The skin cancer balb/c mouse model was utilized in the study. Plant extracts were administered to animals using oral gavage. In addition, skin cancer was induced using 7,12-dimethylbenz( a) anthracene (DMBA).</p><p><strong>Results: </strong>The study found that <i>A. triphylla</i> extract reduced both tumor incidence (P<0.01) and papilloma frequency (<i>P</i><0.001) and delayed the onset of tumor development (<i>P</i><0.001). The <i>A. triphylla</i> extract did not affect tumor size in animals. <i>C. sativum</i> leaf extract reduced the number of tumors per animal, the incidence of tumors, and the frequency of papilloma (<i>P</i><0.05). In addition, it delayed (<i>P</i><0.01) the onset of tumors. Treatment of animals with <i>C. sativum</i> seed extract reduced the frequency of papilloma (P<0.05) and delayed the onset of tumors (<i>P</i><0.05). However, the examined plant extracts did not impact the size of tumors induced by DMBA (<i>P</i>>0.05).</p><p><strong>Conclusion: </strong>The findings of this study revealed that <i>C. sativum</i> and<i> A. triphylla</i> could protect against cancer development as indicated using the animal model of skin painting assay.</p>\",\"PeriodicalId\":10816,\"journal\":{\"name\":\"Current cancer drug targets\",\"volume\":\" \",\"pages\":\"455-462\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current cancer drug targets\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2174/1568009623666230817101757\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current cancer drug targets","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/1568009623666230817101757","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
Coriandrum sativum and Aloysia triphylla can Protect the Development of Cancer: An in Vivo Study using Mouse Painting Assay.
Aim: The aim of this study is to examine the protective properties of Coriandrum sativum and Aloysia triphylla against the development of skin cancer.
Methods: The skin cancer balb/c mouse model was utilized in the study. Plant extracts were administered to animals using oral gavage. In addition, skin cancer was induced using 7,12-dimethylbenz( a) anthracene (DMBA).
Results: The study found that A. triphylla extract reduced both tumor incidence (P<0.01) and papilloma frequency (P<0.001) and delayed the onset of tumor development (P<0.001). The A. triphylla extract did not affect tumor size in animals. C. sativum leaf extract reduced the number of tumors per animal, the incidence of tumors, and the frequency of papilloma (P<0.05). In addition, it delayed (P<0.01) the onset of tumors. Treatment of animals with C. sativum seed extract reduced the frequency of papilloma (P<0.05) and delayed the onset of tumors (P<0.05). However, the examined plant extracts did not impact the size of tumors induced by DMBA (P>0.05).
Conclusion: The findings of this study revealed that C. sativum and A. triphylla could protect against cancer development as indicated using the animal model of skin painting assay.
期刊介绍：
Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes.
Current Cancer Drug Targets publishes original research articles, letters, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer.
As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.
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