累积吸食大麻与中年认知功能之间的性别差异:青年冠状动脉风险发展研究。

IF 3.1 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Cannabis and Cannabinoid Research Pub Date : 2024-08-01 Epub Date: 2023-08-18 DOI:10.1089/can.2022.0343
Baptiste Pasquier, Kristine Yaffe, Deborah A Levine, Jamal S Rana, Mark J Pletcher, Kali Tal, Stephen Sidney, Reto Auer, Julian Jakob
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引用次数: 0

摘要

背景:由于神经生物学机制和环境风险因素的性别差异,吸食大麻可能会对男性和女性的认知功能(CF)造成不同程度的损害。目的:评估男性和女性在累积接触大麻方面的性别差异:评估累积接触大麻与中年认知能力之间的性别差异。方法我们研究了青年冠状动脉风险发展(CARDIA)研究的参与者,包括基线年龄为 18-30 岁的黑人和白人男性和女性,并对他们进行了长达 30 年的跟踪调查。我们按性别对 30 岁时的 CF 评分进行了横断面分析。我们根据 30 年中每 2 至 5 年一次的自我报告使用情况,计算出以 "大麻年"(1 大麻年=365 天的使用时间)为单位的累积暴露类别。在 25 岁和 30 岁时,我们使用雷伊听觉言语学习测试(言语记忆)、数字符号替换测试(处理速度)和 Stroop 干扰测试(执行功能)对 CF 进行评估。30 岁时,额外的测量包括类别和字母流畅性测试(言语能力)和蒙特利尔认知评估(整体认知)。我们计算了每项认知测试的标准化分数,并对自我报告的累计大麻使用情况应用了多变量调整线性回归模型,但不包括在 24 小时内使用大麻的参与者。在一项辅助分析中,我们研究了当前大麻使用情况的变化与 25 至 30 年间 CF 变化之间的关联。结果:到第 30 年,有 1,352 名男性和 1,793 名女性进行了 CF 测量;87%(N=1,171)的男性和 84%(N=1,502)的女性报告曾经吸食大麻。男性的平均累积吸食大麻时间为 2.57 年,女性为 1.29 年。自我报告的累计吸食大麻与男性较差的言语记忆有关(例如,吸食大麻≥5年的标准单位[SU]为-0.49;95% CI=-0.76至-0.23),但与女性无关(SU=0.02;95% CI=-0.26至0.29)。其他 CF 指标与大麻无关。男性和女性在 25 至 30 岁之间当前大麻使用量的变化与 CF 无关。结论:自我报告的累积大麻暴露与男性口头记忆力下降有关,但与女性无关。研究人员在测试大麻与认知之间的关联时,应考虑按性别进行分层分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sex Differences in the Association Between Cumulative Use of Cannabis and Cognitive Function in Middle Age: The Coronary Artery Risk Development in Young Adults Study.

Background: Cannabis use may impair cognitive function (CF) differently in men and women, due to sex-specific differences in neurobiological mechanisms and environmental risk factors. Objective: Assess sex differences in the association between cumulative exposure to cannabis and cognitive performance in middle age. Methods: We studied participants from the Coronary Artery Risk Development in Young Adults (CARDIA) Study, including Black and White men and women 18-30 years old at baseline followed over 30 years. Our cross-sectional analysis of CF scores at year 30 was stratified by sex. We computed categories of cumulative exposure in "cannabis-years" (1 cannabis-year=365 days of use) from self-reported use every 2 to 5 years over 30 years. At years 25 and 30, we assessed CF with the Rey Auditory Verbal Learning Test (verbal memory), the Digit Symbol Substitution Test (processing speed), and the Stroop Interference Test (executive function). At year 30, additional measures included Category and Letter Fluency Test (verbal ability) and the Montreal Cognitive Assessment (global cognition). We computed standardized scores for each cognitive test and applied multivariable adjusted linear regression models for self-reported cumulative cannabis use, excluding participants who used cannabis within 24 h. In a secondary analysis, we examined the association between changes in current cannabis use and changes in CF between years 25 and 30. Results: By year 30, 1,352 men and 1,793 women had measures of CF; 87% (N=1,171) men and 84% (N=1,502) women reported ever cannabis use. Men had a mean cumulative use of 2.57 cannabis-years and women 1.29 cannabis-years. Self-reported cumulative cannabis use was associated with worse verbal memory in men (e.g., -0.49 standardized units [SU] for ≥5 cannabis-years of exposure; 95% CI=-0.76 to -0.23), but not in women (SU=0.02; 95% CI=-0.26 to 0.29). Other measures of CF were not associated with cannabis. Changes in current cannabis use between years 25 and 30 were not associated with CF in men or women. Conclusions: Self-reported cumulative cannabis exposure was associated with worse verbal memory in men but not in women. Researchers should consider stratified analyses by sex when testing the association between cannabis and cognition.

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来源期刊
Cannabis and Cannabinoid Research
Cannabis and Cannabinoid Research PHARMACOLOGY & PHARMACY-
CiteScore
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