绝经后T2dm合并骨质疏松患者及糖尿病骨质疏松小鼠血清鸢尾素与骨密度相关

IF 1.9 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Xiuxiu Hou, Baorui Xing, Guochen Zhang, Hao Wu, Nana Feng, Yunmei Li, Guangpu Han
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引用次数: 0

摘要

背景:骨质疏松症是一种骨量低、骨微结构破坏、骨脆性增加的全身性骨病。众所周知,性别和代谢状况是骨质疏松症的危险因素。鸢尾素是一种新发现的由骨骼肌和脂肪组织分泌的肌因子。据报道,血清鸢尾素在2型糖尿病(T2DM)和/或骨质疏松症患者中降低,并与颈骨骨密度(BMD)相关,但其在绝经后T2DM合并骨质疏松症中的作用仍不清楚。方法:招募伴有或不伴有骨质疏松的绝经后2型糖尿病患者,并以50名年龄匹配的健康绝经后妇女作为健康对照。C57BL/6J小鼠每天腹腔注射链脲佐菌素(STZ) 65 mg/kg,连续5 d诱导糖尿病,并通过尾静脉注射重组鸢尾素蛋白1 mg/kg,每周1次,连续4个月。结果:与健康对照组相比,绝经后T2DM患者血清鸢尾素水平和L1-L4腰椎、股骨颈、全髋关节、Wards的BMD均下降,T2DM合并骨质疏松患者血清鸢尾素水平进一步下降。此外,血清鸢尾素水平也与T2DM患者上述身体部位的BMD相关。此外,重组鸢尾素蛋白改善了stz诱导的糖尿病骨质疏松小鼠的糖尿病骨质疏松和炎症。结论:绝经后T2DM合并骨质疏松患者血清鸢尾素水平明显降低,可能与绝经后T2DM患者骨密度降低及骨质疏松发生有关。T2DM患者早期联合测定血清鸢尾素水平和BMD对骨质疏松症的诊断和治疗有一定的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Serum Irisin is Associated with Bone Mineral Density in Postmenopausal T2dm Patients Complicated with Osteoporosis and in Mice with Diabetic Osteoporosis.

Background: Osteoporosis is a systemic bone disease with low bone mass, destruction of bone microstructure, and increased bone fragility. Gender and metabolic status are well-known risk factors for osteoporosis. Irisin is a newly discovered myokine that is secreted by skeletal muscle and adipose tissue. Serum Irisin was reported to be decreased in type 2 diabetes mellitus (T2DM) and/or osteoporosis patients, and it is correlated with bone mineral density (BMD) of neck bone, but its role in postmenopausal T2DM with osteoporosis remains largely unknown.

Methods: Postmenopausal T2DM patients with or without osteoporosis were recruited, and 50 agematched healthy postmenopausal women were employed as healthy control. C57BL/6J mice were intraperitoneally injected with 65 mg/kg Streptozotocin (STZ) daily for consecutive 5 days to induce diabetes, and 1 mg/kg recombinant Irisin protein was injected into diabetic mice through the tail vein once a week for 4 months.

Results: Compared to that of healthy control, serum Irisin levels and BMD in L1-L4 lumbar spine, femoral neck, total hip, and Wards were decreased in postmenopausal T2DM patients and further decreased in T2DM patients with osteoporosis. Moreover, serum Irisin levels were also correlated with BMD in the above body parts in T2DM patients. Furthermore, recombinant Irisin protein improved diabetic osteoporosis and inflammation in STZ-induced diabetic mice with osteoporosis.

Conclusion: Serum Irisin levels in postmenopausal T2DM patients with osteoporosis were significantly decreased, which may be related to the decreased BMD and the occurrence of osteoporosis in postmenopausal T2DM patients. The combined measurement of serum Irisin levels and BMD in patients with T2DM in the early stage has a certain effect on the diagnosis and treatment of osteoporosis.

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来源期刊
Current protein & peptide science
Current protein & peptide science 生物-生化与分子生物学
CiteScore
5.20
自引率
0.00%
发文量
73
审稿时长
6 months
期刊介绍: Current Protein & Peptide Science publishes full-length/mini review articles on specific aspects involving proteins, peptides, and interactions between the enzymes, the binding interactions of hormones and their receptors; the properties of transcription factors and other molecules that regulate gene expression; the reactions leading to the immune response; the process of signal transduction; the structure and function of proteins involved in the cytoskeleton and molecular motors; the properties of membrane channels and transporters; and the generation and storage of metabolic energy. In addition, reviews of experimental studies of protein folding and design are given special emphasis. Manuscripts submitted to Current Protein and Peptide Science should cover a field by discussing research from the leading laboratories in a field and should pose questions for future studies. Original papers, research articles and letter articles/short communications are not considered for publication in Current Protein & Peptide Science.
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