用简化激光光度法对加压计量剂量吸入器和带阀容纳室的气溶胶释放进行动态分析。

IF 2 4区 医学 Q3 RESPIRATORY SYSTEM
Tetsuri Kondo, Toshimori Tanigaki, Makoto Hibino, Sakurako Tajiri, Shigeto Horiuchi, Kazunari Maeda, Shunichi Tobe, Riko Kamada
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引用次数: 0

摘要

背景:加压计量吸入器结合带阀容纳室(pMDI+VHC)用于预防上呼吸道并发症,提高吸入药物递送的效率;然而,释放颗粒的空气动力学行为尚未得到很好的研究。本研究旨在使用简化的激光光度法澄清VHC的颗粒释放轮廓。方法:一个吸入模拟器包括一个计算机控制的泵和一个阀门系统,该系统使用跳跃式流动剖面从pMDI+VHC中抽取气溶胶。红色激光照射离开VHC的粒子,并评估释放的粒子反射的光的强度。结果:数据表明,激光反射系统的输出(OPT)代表粒子浓度,而不是粒子质量,后者被计算为OPT × 瞬时抽取流量(WF)。OPT的总和随着流量的增加而夸张地减少,而OPT的和 × 瞬时流量不受WF强度的影响。粒子释放轨迹由三个阶段组成,即抛物线递增、平坦和指数衰减阶段递减。平坦相仅出现在低流量提取时。这些颗粒物释放情况表明了早期吸入的重要性。WF和颗粒释放时间之间的双曲线关系揭示了在单个提取强度下所需的最小提取时间。结论:粒子释放质量计算为激光光度输出 × 瞬时流量。对释放颗粒的模拟表明了早期吸入的重要性,并预测了pMDI+VHC所需的最低退出时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dynamic Analysis of Aerosol Release from a Pressurized Metered Dose Inhaler Combined with a Valved Holding Chamber Using Simplified Laser Photometry.

Background: A pressurized metered dose inhaler combined with a valved holding chamber (pMDI+VHC) is used to prevent upper airway complications and improve the efficiency of inhaled drug delivery; however, the aerodynamic behavior of the released particles has not been well investigated. This study aimed at clarifying the particle release profiles of a VHC using simplified laser photometry. Methods: An inhalation simulator comprised a computer-controlled pump and a valve system that withdrew aerosol from a pMDI+VHC using a jump-up flow profile. A red laser illuminated the particles leaving VHC and evaluated the intensity of the light reflected by the released particles. Results: The data suggested that the output (OPT) from the laser reflection system represented particle concentration rather than particle mass, and the latter was calculated as OPT × instantaneous withdrawn flow (WF). Summation of OPT hyperbolically decreased with flow increment, whereas summation of OPT × instantaneous flow was not influenced by WF strength. Particle release trajectories consisted of three phases, namely increment with a parabolic curve, flat, and decrement with exponential decay phases. The flat phase appeared exclusively at low-flow withdrawal. These particle release profiles suggest the importance of early phase inhalation. The hyperbolic relationship between WF and particle release time revealed the minimal required withdrawal time at an individual withdrawal strength. Conclusions: The particle release mass was calculated as laser photometric output × instantaneous flow. Simulation of the released particles suggested the importance of early phase inhalation and predicted the minimally required withdrawal time from a pMDI+VHC.

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来源期刊
CiteScore
6.70
自引率
2.90%
发文量
34
审稿时长
>12 weeks
期刊介绍: Journal of Aerosol Medicine and Pulmonary Drug Delivery is the only peer-reviewed journal delivering innovative, authoritative coverage of the health effects of inhaled aerosols and delivery of drugs through the pulmonary system. The Journal is a forum for leading experts, addressing novel topics such as aerosolized chemotherapy, aerosolized vaccines, methods to determine toxicities, and delivery of aerosolized drugs in the intubated patient. Journal of Aerosol Medicine and Pulmonary Drug Delivery coverage includes: Pulmonary drug delivery Airway reactivity and asthma treatment Inhalation of particles and gases in the respiratory tract Toxic effects of inhaled agents Aerosols as tools for studying basic physiologic phenomena.
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