靶向 SARM1 可改善自噬应激诱导的轴索神经病变

IF 14.6 1区生物学 Q1 CELL BIOLOGY

Autophagy Pub Date : 2024-01-01 Epub Date: 2023-08-18 DOI:10.1080/15548627.2023.2244861

Hye Ran Kim, Hye Jin Lee, Yewon Jeon, So Young Jang, Yoon Kyoung Shin, Jean Ho Yun, Hye Ji Park, Hyongjong Koh, Kyung Eun Lee, Jung Eun Shin, Hwan Tae Park

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引用次数: 0

摘要

缩写：缩写： AAV：腺相关病毒；ATF3：激活转录因子 3；ATG7：自噬相关 7；AVIL：advillin；cADPR：环 ADP 核糖；CALC：降钙素/降钙素相关多肽；CMT：Charcot-Marie-Tooth 病；cKO：条件性基因敲除；DEG：差异表达基因；DRG：FE-SEM：场发射扫描电子显微镜；IF：免疫荧光；NCV：神经传导速度；PVALB：parvalbumin；RAG：再生相关基因；ROS：活性氧；SARM1：不育α和 HEAT/Armadillo motif containing 1；SYN1：突触素 I。

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Targeting SARM1 improves autophagic stress-induced axonal neuropathy.

Abbreviations: AAV: adeno-associated virus; ATF3: activating transcription factor 3; ATG7: autophagy related 7; AVIL: advillin; cADPR: cyclic ADP ribose; CALC: calcitonin/calcitonin-related polypeptide; CMT: Charcot-Marie-Tooth disease; cKO: conditional knockout; DEG: differentially expressed gene; DRG: dorsal root ganglion; FE-SEM: field emission scanning electron microscopy; IF: immunofluorescence; NCV: nerve conduction velocity; PVALB: parvalbumin; RAG: regeneration-associated gene; ROS: reactive oxygen species; SARM1: sterile alpha and HEAT/Armadillo motif containing 1; SYN1: synapsin I.

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来源期刊

Autophagy 生物-细胞生物学

CiteScore

21.30

自引率

2.30%

发文量

277

审稿时长

1 months

期刊介绍： Autophagy is a peer-reviewed journal that publishes research on autophagic processes, including the lysosome/vacuole dependent degradation of intracellular material. It aims to be the premier journal in the field and covers various connections between autophagy and human health and disease, such as cancer, neurodegeneration, aging, diabetes, myopathies, and heart disease. Autophagy is interested in all experimental systems, from yeast to human. Suggestions for specialized topics are welcome. The journal accepts the following types of articles: Original research, Reviews, Technical papers, Brief Reports, Addenda, Letters to the Editor, Commentaries and Views, and Articles on science and art. Autophagy is abstracted/indexed in Adis International Ltd (Reactions Weekly), EBSCOhost (Biological Abstracts), Elsevier BV (EMBASE and Scopus), PubMed, Biological Abstracts, Science Citation Index Expanded, Web of Science, and MEDLINE.