高脂肪饮食会加剧骨骼肌结构和功能与年龄相关的衰退。

IF 4.9 2区医学 Q1 PHYSIOLOGY

Exercise and Sport Sciences Reviews Pub Date : 2021-10-01 DOI:10.1249/JES.0000000000000261

Hans Degens, Anandini Swaminathan, Jason Tallis

{"title":"高脂肪饮食会加剧骨骼肌结构和功能与年龄相关的衰退。","authors":"Hans Degens, Anandini Swaminathan, Jason Tallis","doi":"10.1249/JES.0000000000000261","DOIUrl":null,"url":null,"abstract":"The age-related decline in muscle function is aggravated by a high-fat diet (HFD)-induced increase in fat mass. The hypothesis is that an HFD leads to a faster accumulation of intramyocellular lipids (IMCL) and an earlier onset of muscle dysfunction in old than in young-adult individuals. The IMCL accumulation is attenuated in young-adult organisms by an elevated oxidative capacity. Methionine restriction enhances mitochondrial biogenesis and is promising to combat obesity across the ages.","PeriodicalId":55157,"journal":{"name":"Exercise and Sport Sciences Reviews","volume":"49 4","pages":"253-259"},"PeriodicalIF":4.9000,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"A High-Fat Diet Aggravates the Age-Related Decline in Skeletal Muscle Structure and Function.\",\"authors\":\"Hans Degens, Anandini Swaminathan, Jason Tallis\",\"doi\":\"10.1249/JES.0000000000000261\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The age-related decline in muscle function is aggravated by a high-fat diet (HFD)-induced increase in fat mass. The hypothesis is that an HFD leads to a faster accumulation of intramyocellular lipids (IMCL) and an earlier onset of muscle dysfunction in old than in young-adult individuals. The IMCL accumulation is attenuated in young-adult organisms by an elevated oxidative capacity. Methionine restriction enhances mitochondrial biogenesis and is promising to combat obesity across the ages.\",\"PeriodicalId\":55157,\"journal\":{\"name\":\"Exercise and Sport Sciences Reviews\",\"volume\":\"49 4\",\"pages\":\"253-259\"},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2021-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Exercise and Sport Sciences Reviews\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1249/JES.0000000000000261\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Exercise and Sport Sciences Reviews","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1249/JES.0000000000000261","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}

引用次数: 2

摘要

高脂肪饮食(HFD)引起的脂肪量增加加剧了与年龄相关的肌肉功能下降。假设HFD导致老年人比年轻人更快地积累细胞内脂质(IMCL)和更早地出现肌肉功能障碍。在年轻的成体生物体中，IMCL的积累通过氧化能力的提高而减弱。蛋氨酸限制增强了线粒体的生物生成，有望在各个年龄段对抗肥胖。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

A High-Fat Diet Aggravates the Age-Related Decline in Skeletal Muscle Structure and Function.

The age-related decline in muscle function is aggravated by a high-fat diet (HFD)-induced increase in fat mass. The hypothesis is that an HFD leads to a faster accumulation of intramyocellular lipids (IMCL) and an earlier onset of muscle dysfunction in old than in young-adult individuals. The IMCL accumulation is attenuated in young-adult organisms by an elevated oxidative capacity. Methionine restriction enhances mitochondrial biogenesis and is promising to combat obesity across the ages.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Exercise and Sport Sciences Reviews 社会科学-生理学

CiteScore

10.70

自引率

1.80%

发文量

期刊介绍： Exercise and Sport Sciences Reviews made the transition from an annual hardcover series book to a quarterly journal in January 2000. The mission of this American College of Sports Medicine publication is to provide premier quarterly reviews of the most contemporary scientific, medical, and research-based topics emerging in the field of sports medicine and exercise science. The publication strives to provide the most relevant, topical information to students, professors, clinicians, scientists, and professionals for practical and research applications.