类风湿性关节炎药物给药途径的最新进展。

IF 3.5 4区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current medicinal chemistry Pub Date : 2025-01-01 DOI:10.2174/0929867331666230815112818

Abhishek Verma, Preeti Patel, Waleed Hassan Almalki, Amirhossein Sahebkar, Balak Das Kurmi, Prashant Kesharwani

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引用次数: 0

摘要

与类风湿性关节炎(RA)相关的发病率、残疾和医疗费用给患者和医疗保健系统带来了相当大的健康和经济负担。本综述旨在研究RA的病理生理方面，这可能有助于设计不同类型的药物和药物输送系统。这些包括单克隆抗体、免疫球蛋白、微小化学物质和用于基因治疗的转基因。这些新的基于纳米载体的治疗方法针对RA的潜在生物学过程，同时最大限度地减少药物的全身不良反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Recent Advances in Drug Delivery Approaches for Rheumatoid Arthritis.

Morbidity, disability, and healthcare expenses associated with rheumatoid arthritis (RA) impose a considerable health and economical burden on both patients and healthcare systems. This review aimed to examine the pathophysiological aspects of RA that may help design different types of drugs and drug delivery systems. These include monoclonal antibodies, immunoglobulins, tiny chemicals, and transgenes for gene therapy. These novel nanocarrier-based therapies target the underlying biological processes involved in RA while minimizing the systemic adverse effects of drugs.

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来源期刊

Current medicinal chemistry 医学-生化与分子生物学

CiteScore

8.60

自引率

2.40%

发文量

468

审稿时长

3 months

期刊介绍： Aims & Scope Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.