Maternal and perinatal outcomes of COVID-19 vaccination during pregnancy.

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Journal of the Turkish German Gynecological Association Pub Date : 2023-06-07 DOI:10.4274/jtgga.galenos.2023.2022-9-10

Hasan Süt, Gülşah Aynaoğlu Yıldız, Erdal Şeker, Coşkun Ümit, Mustafa Koçar, Acar Koç

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引用次数: 0

Abstract

Objective: To investigate maternal adverse effects and perinatal and neonatal outcomes of women receiving coronavirus disease-2019 (COVID-19) vaccination during pregnancy.

Material and methods: Seven hundred and sixty pregnant women who were followed up in obstetrics outpatients were included in this prospective cohort study. COVID-19 vaccination and infection histories of the patients were recorded. Demographic data, including age, parity, and presence of systemic disease and adverse events following COVID-19 vaccination were recorded. Vaccinated pregnant women were compared with unvaccinated women in terms of adverse perinatal and neonatal outcomes.

Results: Among the 760 pregnant women who met study criteria, the data of 425 pregnant women were analyzed. Among these, 55 (13%) were unvaccinated, 134 (31%) were vaccinated before pregnancy, and 236 (56%) pregnant women were vaccinated during pregnancy. Of those who were vaccinated, 307 patients (83%) received BioNTech, 52 patients (14%) received CoronaVac, and 11 patients (3%) received both CoronaVac and BioNTech. The local and systemic adverse effect profiles of patients who received COVID-19 vaccination either before or during pregnancy were similar (p=0.159), and the most common adverse effect was injection site pain. COVID-19 vaccination during pregnancy did not increase the ratio of abortion (<14 wk), stillbirth (>24 wk), preeclampsia, gestational diabetes mellitus, fetal growth restriction, second-trimester soft marker incidence, time of delivery, birth weight, preterm birth (<37 wk) or admission to the neonatal intensive care unit compared to the women who were not vaccinated during pregnacy.

Conclusion: COVID-19 vaccination during pregnancy did not increase maternal local and systemic adverse effects or poor perinatal and neonatal outcomes. Therefore, regarding the increased risk of morbidity and mortality related to COVID-19 in pregnant women, the authors propose that COVID-19 vaccination should be offered to all pregnant women.

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妊娠期间新冠肺炎疫苗接种的孕产妇和围产期结果。

目的：了解妊娠期接种2019冠状病毒病（新冠肺炎）疫苗的产妇不良反应、围产期和新生儿结局。材料和方法：在产科门诊随访的760名孕妇被纳入这项前瞻性队列研究。记录患者的新冠肺炎疫苗接种和感染史。记录了人口统计学数据，包括年龄、产次、新冠肺炎疫苗接种后全身性疾病和不良事件的存在。将接种疫苗的孕妇与未接种疫苗的妇女的不良围产期和新生儿结局进行比较。结果：在符合研究标准的760名孕妇中，对425名孕妇的数据进行了分析。其中，55人（13%）未接种疫苗，134人（31%）在怀孕前接种了疫苗，236名孕妇（56%）在怀孕期间接种了疫苗。在接种疫苗的患者中，307名患者（83%）接受了BioNTech，52名患者（14%）接受了CoronaVac，11名患者（3%）同时接受了CornaVac和BioNTech。在怀孕前或怀孕期间接种新冠肺炎疫苗的患者的局部和全身不良反应情况相似（p=0.159），最常见的不良反应是注射部位疼痛。妊娠期间接种新冠肺炎疫苗不会增加流产（24周）、先兆子痫、妊娠期糖尿病、胎儿生长受限、妊娠中期软标志物发病率、分娩时间、出生体重、，早产（结论：妊娠期间接种新冠肺炎疫苗不会增加产妇的局部和全身不良反应或不良的围产期和新生儿结局。因此，关于孕妇新冠肺炎相关发病率和死亡率的增加，作者建议向所有孕妇提供新冠肺炎疫苗接种。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Turkish German Gynecological Association OBSTETRICS & GYNECOLOGY-

CiteScore

2.40

自引率

7.10%

发文量

期刊介绍： Journal of the Turkish-German Gynecological Association is the official, open access publication of the Turkish-German Gynecological Education and Research Foundation and Turkish-German Gynecological Association and is published quarterly on March, June, September and December. It is an independent peer-reviewed international journal printed in English language. Manuscripts are reviewed in accordance with “double-blind peer review” process for both reviewers and authors. The target audience of Journal of the Turkish-German Gynecological Association includes gynecologists and primary care physicians interested in gynecology practice. It publishes original works on all aspects of obstertrics and gynecology. The aim of Journal of the Turkish-German Gynecological Association is to publish high quality original research articles. In addition to research articles, reviews, editorials, letters to the editor, diagnostic puzzle are also published. Suggestions for new books are also welcomed. Journal of the Turkish-German Gynecological Association does not charge any fee for article submission or processing.